RGD Reference Report - [Study of regulation of Puerarin on blood P-selectin and the expression of aorta VCAM mRNA in diabetes] - Rat Genome Database

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[Study of regulation of Puerarin on blood P-selectin and the expression of aorta VCAM mRNA in diabetes]

Authors: Li, Q  Zhang, X  Zhu, F  Zhang, Z  Et, AL 
Citation: Li Q, etal., Wei Sheng Yan Jiu. 2007 Sep;36(5):581-3, 595.
RGD ID: 2312301
Pubmed: PMID:18095572   (View Abstract at PubMed)

OBJECTIVE: To observe the regulation of Puerarin on blood P-selectin and expression of aorta vascular cell adhesion molecule (VCAM) in diabetic rats induced by Streptozotocin. METHODS: Diabetic rats were induced by intraperitoneal injection of STZ. Rats were divided into normal control group, model group, and three Puerarin groups (20, 40 and 80 mg/kg, ip) for 16 weeks. After the treatment, its cholesterol, low density lipoprotein, high density lipoprotein, P-selectin, oxidative low density lipoprotein and glycosylated low density lipoprotein. Alteration of tissue morphology via H. E staining was observed after the aorta was taken out from the rats executed by narcosis. VCAM mRNA were determined by in situ hybridization analysis. RESULTS: (1) Diabetes mellitus and aorta lesion occurred in the four model groups. (2) Puerarin could decrease the levels of cholesterol (P < 0.05), low density lipoprotein (P < 0.05), P-selectin (P < 0.05), oxidative low density lipoprotein, and glycosylated low density (P < 0.05), lipoprotein increase high density lipoprotein (P < 0.05). The gene expression of VCAM in the aorta were significantly inhibited, and the action of Puerarin showed some dose reaction relationship at the same time (P < 0.05). CONCLUSION: Puerarin have a certain in preventing aorta by inhibiting expression of adhesion molecule.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SELPHumanExperimental Diabetes Mellitus treatmentISOSelp (Rattus norvegicus) RGD 
SelpRatExperimental Diabetes Mellitus treatmentIDA  RGD 
SelpMouseExperimental Diabetes Mellitus treatmentISOSelp (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Selp  (selectin P)

Genes (Mus musculus)
Selp  (selectin, platelet)

Genes (Homo sapiens)
SELP  (selectin P)


Additional Information