RGD Reference Report - Expression of CD38 gene, but not of mitochondrial glycerol-3-phosphate dehydrogenase gene, is impaired in pancreatic islets of GK rats. - Rat Genome Database

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Expression of CD38 gene, but not of mitochondrial glycerol-3-phosphate dehydrogenase gene, is impaired in pancreatic islets of GK rats.

Authors: Matsuoka, T  Kajimoto, Y  Watada, H  Umayahara, Y  Kubota, M  Kawamori, R  Yamasaki, Y  Kamada, T 
Citation: Matsuoka T, etal., Biochem Biophys Res Commun. 1995 Sep 5;214(1):239-46.
RGD ID: 2307234
Pubmed: PMID:7669044   (View Abstract at PubMed)

Goto-Kakizaki (GK) rat, a rodent model of spontaneously occurring non-insulin dependent diabetes mellitus (NIDDM), exhibits impaired glucose-stimulated insulin secretion. To explore the background of the beta-cell dysfunction in NIDDM, we investigated whether and how the expression pattern of factors that would potentially be involved in the glucose-stimulated insulin secretion machinery is changed in GK rats. Using quantitative reverse transcription-PCR (RT-PCR) method, we found that the gene expression of CD38, a type 2 membrane protein which has ADP-ribosyl cyclase activity, is reduced by approximately 50% in islets of GK rats. Despite previous studies showing reduction in the FAD-linked mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) activity in GK rats, the mGPDH mRNA amounts were equal to those in the control Wistar rats, suggesting a difference that arose post-transcriptionally. These observations support the idea that multiple defects of the glucose-responsive insulin secreting machinery are involved in the development of diabetes in GK rats.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD38Humantype 2 diabetes mellitus  ISOCd38 (Rattus norvegicus)mRNA:decreased expression:pancreatic isletRGD 
Cd38Rattype 2 diabetes mellitus  IEP mRNA:decreased expression:pancreatic isletRGD 
Cd38Mousetype 2 diabetes mellitus  ISOCd38 (Rattus norvegicus)mRNA:decreased expression:pancreatic isletRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd38  (CD38 molecule)

Genes (Mus musculus)
Cd38  (CD38 antigen)

Genes (Homo sapiens)
CD38  (CD38 molecule)


Additional Information