RGD Reference Report - CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. - Rat Genome Database

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CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior.

Authors: Bale, TL  Davis, AM  Auger, AP  Dorsa, DM  McCarthy, MM 
Citation: Bale TL, etal., J Neurosci. 2001 Apr 1;21(7):2546-52.
RGD ID: 2304217
Pubmed: PMID:11264328   (View Abstract at PubMed)
PMCID: PMC6762393   (View Article at PubMed Central)

The oxytocin receptor (OTR) is differentially expressed in the CNS. Because there are multiple mechanisms by which the OTR can be transcriptionally induced, we hypothesized that differences in OTR expression may be explained by activation of distinct signal transduction pathways and may be critical for the control of anxiety and sex behaviors. To determine the regulation and functional significance of this expression, we infused female rats with modifiers of protein kinases before assaying for behavior and oxytocin receptor binding. In the ventromedial nucleus of the hypothalamus (VMH), estrogen-dependent induction of oxytocin receptors required protein kinase C activation, and oxytocin infused here promoted female sex behavior but had no effect on anxiety. In contrast, dopamine controlled tonic oxytocin receptor expression in the central nucleus of the amygdala (cAmyg) through activation of protein kinase A, and oxytocin infused here was anxiolytic but had no effect on female sex behavior. Therefore, we have identified brain region-specific regulation of the OTR in the VMH and cAmyg. Distinct signal transduction pathways regulating receptor expression and binding in each brain region may mediate in part the ability of oxytocin to exert these differential behavioral effects.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
OxtRatpositive regulation of female receptivity  IDA  RGD 
OxtrRatresponse to organic cyclic compound  IEP phorbol myristate acetateRGD 

Objects Annotated

Genes (Rattus norvegicus)
Oxt  (oxytocin/neurophysin I prepropeptide)
Oxtr  (oxytocin receptor)


Additional Information