RGD Reference Report - Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. - Rat Genome Database

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Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis.

Authors: Chen, B  Blair, DG  Plisov, S  Vasiliev, G  Perantoni, AO  Chen, Q  Athanasiou, M  Wu, JY  Oppenheim, JJ  Yang, D 
Citation: Chen B, etal., J Immunol. 2004 Nov 15;173(10):5914-7.
RGD ID: 2303400
Pubmed: PMID:15528323   (View Abstract at PubMed)

Drm/Gremlin and Dan, two homologous secreted antagonists of bone morphogenic proteins, have been shown to regulate early development, tumorigenesis, and renal pathophysiology. In this study, we report that Drm and Dan physically and functionally interact with Slit1 and Slit2 proteins. Drm binding to Slits depends on its glycosylation and is not interfered with by bone morphogenic proteins. Importantly, Drm and Dan function as inhibitors for monocyte migration induced by stromal cell-derived factor 1alpha (SDF-1alpha) or fMLP. The inhibition of SDF-1alpha-induced monocyte chemotaxis by Dan is not due to blocking the binding of SDF-1alpha to its receptor. Thus, the results identify that Drm and Dan can interact with Slit proteins and act as inhibitors of monocyte chemotaxis, demonstrating a previously unidentified biological role for these proteins.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Grem1Ratnegative regulation of leukocyte chemotaxis  IDA  RGD 
Grem1Ratnegative regulation of monocyte chemotaxis involved_inIDA PMID:15528323BHF-UCL 
Slit2Ratnegative regulation of monocyte chemotaxis involved_inIDA PMID:15528323BHF-UCL 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Grem1Ratprotein binding enablesIPIUniProtKB:O88279PMID:15528323BHF-UCL 
Grem1Ratprotein binding enablesIPIUniProtKB:Q9WVC1PMID:15528323BHF-UCL 
Grem1Ratprotein binding  IPIRGD:733848|RGD:733021 RGD 
Slit1Ratprotein binding enablesIPIUniProtKB:O35793PMID:15528323BHF-UCL 
Slit1Ratprotein binding enablesIPIUniProtKB:Q61477PMID:15528323BHF-UCL 
Slit2Ratprotein binding enablesIPIUniProtKB:O35793PMID:15528323BHF-UCL 
Slit2Ratprotein binding enablesIPIUniProtKB:Q61477PMID:15528323BHF-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Grem1  (gremlin 1, DAN family BMP antagonist)
Slit1  (slit guidance ligand 1)
Slit2  (slit guidance ligand 2)


Additional Information