RGD Reference Report - High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis.

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High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis.
Authors:	Tang, L Wang, TT Wu, YT Zhou, CY Huang, HF
Citation:	Tang L, etal., Fertil Steril. 2008 Mar 17.
RGD ID:	2299937
Pubmed:	PMID:18353325 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.fertnstert.2008.01.041 (Journal Full-text)
OBJECTIVE: To investigate the possible roles of cyclin B1/cyclin-dependent kinase (cdc2) and Polo-like kinase 1 (Plk1) in the pathogenesis of endometriosis. DESIGN: A case-control study. SETTING: University hospital. PATIENT(S): Patients with or without endometriosis were diagnosed by pathological examination or laparoscopy. The patients with the following criteria within the past 6 months were excluded: endocrine or inflammatory diseases, pregnancy or lactation, hormonal therapy, and neoplasm in the uterine cavity. INTERVENTION(S): Eutopic and ectopic endometria were obtained at the time of surgery. Blood was collected on the same day as surgery. MAIN OUTCOME MEASURE(S): The mRNA/protein expression and localization of cyclin B1, cdc2, and Plk1 in endometrium, and serum levels of E(2) and P. RESULT(S): The expression levels of cyclin B1 and Plk1, but not cdc2, in ectopic endometria were significantly higher than in eutopic endometria. The immunohistochemical staining of cyclin B1 and Plk1 was detected in the nuclei of ectopic and eutopic endometrial cells. Furthermore, ectopic endometrial expression levels of cyclin B1 or Plk1 were positively correlated with serum E(2) levels. CONCLUSION(S): Cyclin B1 and Plk1 may play important roles in the pathogenesis of endometriosis by mediating ectopic endometrial cell proliferation under regulation of ovarian hormones.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
PLK1	Human	endometriosis		IEP		mRNA and protein:increased expression	RGD
Plk1	Rat	endometriosis		ISO	PLK1 (Homo sapiens)	mRNA and protein:increased expression	RGD
Plk1	Mouse	endometriosis		ISO	PLK1 (Homo sapiens)	mRNA and protein:increased expression	RGD

Objects Annotated

Genes (Rattus norvegicus)

Plk1 (polo-like kinase 1)

Genes (Mus musculus)

Plk1 (polo like kinase 1)

Genes (Homo sapiens)

PLK1 (polo like kinase 1)

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High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis.