1,3-dinitrobenzene decreases expression ISO Plk1 (Rattus norvegicus) 6480464 3-dinitrobenzene results in decreased expression of PLK1 mRNA CTD PMID:22841810 1-chloro-2,4-dinitrobenzene increases expression EXP 6480464 Dinitrochlorobenzene results in increased expression of PLK1 mRNA CTD PMID:21404309 1-naphthyl isothiocyanate increases expression ISO Plk1 (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate results in increased expression of PLK1 mRNA CTD PMID:30723492 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of PLK1 mRNA CTD PMID:25210133 17beta-estradiol affects expression ISO Plk1 (Rattus norvegicus) 6480464 Estradiol affects the expression of PLK1 mRNA CTD PMID:32145629 17beta-estradiol multiple interactions ISO PLK1 (Homo sapiens) 6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of PLK1 protein] and Tamoxifen inhibits the reaction [Estradiol results in increased expression of PLK1 protein] CTD PMID:20208560 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of PLK1 mRNA CTD PMID:15598610 17beta-estradiol increases expression ISO PLK1 (Homo sapiens) 6480464 Estradiol results in increased expression of PLK1 protein CTD PMID:20208560 17beta-estradiol multiple interactions EXP 6480464 ESR1 protein promotes the reaction [Estradiol results in increased expression of PLK1 mRNA] CTD PMID:25210133 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO Plk1 (Rattus norvegicus) 6480464 2 more ... CTD PMID:27291303 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PLK1 mRNA CTD PMID:15667827 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of PLK1 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Plk1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of PLK1 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PLK1 mRNA CTD PMID:21570461 2,3-dimethoxynaphthalene-1,4-dione increases expression ISO PLK1 (Homo sapiens) 6480464 2 more ... CTD PMID:19031421 2,4-dinitrotoluene affects expression ISO Plk1 (Rattus norvegicus) 6480464 2 and 4-dinitrotoluene affects the expression of PLK1 mRNA CTD PMID:21346803 2-amino-2-deoxy-D-glucopyranose increases expression EXP 6480464 Glucosamine results in increased expression of PLK1 mRNA CTD PMID:17178593 2-amino-2-deoxy-D-glucopyranose decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Glucosamine results in decreased expression of PLK1 mRNA CTD PMID:17109745 2-methoxyethanol decreases expression ISO Plk1 (Rattus norvegicus) 6480464 methyl cellosolve results in decreased expression of PLK1 mRNA CTD PMID:9681501 2-palmitoylglycerol increases expression ISO PLK1 (Homo sapiens) 6480464 2-palmitoylglycerol results in increased expression of PLK1 mRNA CTD PMID:37199045 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Plk1 (Rattus norvegicus) 6480464 3 more ... CTD PMID:23196670 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression EXP 6480464 Oxazolone results in increased expression of PLK1 mRNA CTD PMID:21404309 4-hydroxynon-2-enal decreases expression EXP 6480464 4-hydroxy-2-nonenal results in decreased expression of PLK1 mRNA CTD PMID:19191707 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of PLK1 mRNA CTD PMID:28973697 5-fluorouracil increases expression ISO PLK1 (Homo sapiens) 6480464 Fluorouracil results in increased expression of PLK1 protein CTD PMID:15016801 5-fluorouracil decreases expression ISO PLK1 (Homo sapiens) 6480464 Fluorouracil results in decreased expression of PLK mRNA and Fluorouracil results in decreased expression of PLK1 mRNA CTD PMID:15205334 and PMID:16709241 5-fluorouracil multiple interactions ISO PLK1 (Homo sapiens) 6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of PLK1 mRNA] and TP53 protein inhibits the reaction [Fluorouracil results in increased expression of PLK1 protein] CTD PMID:15016801 6-propyl-2-thiouracil increases expression ISO Plk1 (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of PLK1 mRNA CTD PMID:24780913 acetamide increases expression ISO Plk1 (Rattus norvegicus) 6480464 acetamide results in increased expression of PLK1 mRNA CTD PMID:31881176 acrolein multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PLK1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PLK1 mRNA CTD PMID:32699268 aflatoxin B1 increases expression ISO Plk1 (Rattus norvegicus) 6480464 Aflatoxin B1 results in increased expression of PLK1 mRNA CTD PMID:23630614 and PMID:25378103 aflatoxin B1 decreases expression ISO PLK1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased expression of PLK1 mRNA CTD PMID:32234424 aldehydo-D-glucosamine increases expression EXP 6480464 Glucosamine results in increased expression of PLK1 mRNA CTD PMID:17178593 aldehydo-D-glucosamine decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Glucosamine results in decreased expression of PLK1 mRNA CTD PMID:17109745 aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of PLK1 mRNA CTD PMID:17178593 all-trans-retinoic acid decreases expression ISO PLK1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of PLK1 mRNA CTD PMID:16249480 more ... alpha-pinene multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PLK1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PLK1 mRNA CTD PMID:32699268 ammonium chloride affects expression ISO Plk1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of PLK1 mRNA CTD PMID:16483693 arsenite(3-) decreases expression EXP 6480464 arsenite results in decreased expression of PLK1 mRNA CTD PMID:18929588 arsenite(3-) multiple interactions ISO PLK1 (Homo sapiens) 6480464 arsenite inhibits the reaction [G3BP1 protein binds to PLK1 mRNA] CTD PMID:32406909 arsenous acid multiple interactions ISO PLK1 (Homo sapiens) 6480464 4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of PLK1 protein] more ... CTD PMID:31597699 arsenous acid increases phosphorylation ISO PLK1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased phosphorylation of PLK1 protein CTD PMID:31597699 atrazine increases expression ISO PLK1 (Homo sapiens) 6480464 Atrazine results in increased expression of PLK1 mRNA CTD PMID:22378314 beauvericin decreases expression ISO PLK1 (Homo sapiens) 6480464 beauvericin results in decreased expression of PLK1 mRNA CTD PMID:29203277 benzo[a]pyrene decreases expression ISO PLK1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of PLK1 mRNA and Benzo(a)pyrene results in decreased expression of PLK1 protein CTD PMID:20064835 more ... benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PLK1 mRNA CTD PMID:32417428 benzo[a]pyrene increases methylation ISO PLK1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of PLK1 promoter CTD PMID:27901495 benzo[a]pyrene decreases methylation ISO PLK1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of PLK1 exon CTD PMID:27901495 benzo[a]pyrene diol epoxide I decreases expression ISO PLK1 (Homo sapiens) 6480464 7 more ... CTD PMID:19150397 more ... benzo[b]fluoranthene increases expression EXP 6480464 benzo(b)fluoranthene results in increased expression of PLK1 mRNA CTD PMID:26377693 beta-D-glucosamine increases expression EXP 6480464 Glucosamine results in increased expression of PLK1 mRNA CTD PMID:17178593 beta-D-glucosamine decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Glucosamine results in decreased expression of PLK1 mRNA CTD PMID:17109745 beta-naphthoflavone multiple interactions ISO Plk1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLK mRNA CTD PMID:18164116 bis(2-chloroethyl) sulfide decreases expression ISO PLK1 (Homo sapiens) 6480464 Mustard Gas results in decreased expression of PLK1 mRNA CTD PMID:25102026 bisphenol A decreases expression ISO Plk1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of PLK1 mRNA CTD PMID:26982218 and PMID:30816183 bisphenol A affects expression ISO PLK1 (Homo sapiens) 6480464 bisphenol A affects the expression of PLK1 mRNA CTD PMID:35628146 bisphenol A multiple interactions ISO PLK1 (Homo sapiens) 6480464 bisphenol A results in increased expression of and affects the localization of PLK1 protein CTD PMID:30980863 bisphenol A decreases expression ISO PLK1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of PLK1 mRNA and bisphenol A results in decreased expression of PLK1 protein CTD PMID:29275510 more ... bisphenol A affects expression ISO Plk1 (Rattus norvegicus) 6480464 bisphenol A affects the expression of PLK1 mRNA CTD PMID:25181051 and PMID:32145629 cadmium atom decreases expression ISO PLK1 (Homo sapiens) 6480464 Cadmium results in decreased expression of PLK1 mRNA CTD PMID:21120746 cadmium atom multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PLK1 mRNA CTD PMID:35301059 cadmium dichloride multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PLK1 mRNA CTD PMID:35301059 caffeine decreases phosphorylation ISO PLK1 (Homo sapiens) 6480464 Caffeine results in decreased phosphorylation of PLK1 protein CTD PMID:35688186 calcitriol multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of PLK1 mRNA CTD PMID:21592394 calcitriol decreases expression ISO PLK1 (Homo sapiens) 6480464 Calcitriol results in decreased expression of PLK1 mRNA CTD PMID:21592394 cannabidiol decreases expression ISO PLK1 (Homo sapiens) 6480464 Cannabidiol results in decreased expression of PLK1 mRNA CTD PMID:36519830 carbon nanotube increases expression EXP 6480464 Nanotubes more ... CTD PMID:25554681 cefaloridine decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Cephaloridine results in decreased expression of PLK1 mRNA CTD PMID:18500788 CGP 52608 multiple interactions ISO PLK1 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to PLK1 gene] CTD PMID:28238834 Chloroacetonitrile affects localization EXP 6480464 chloroacetonitrile affects the localization of PLK1 protein CTD PMID:36940772 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLK1 mRNA CTD PMID:20938992 chromium atom multiple interactions ISO PLK1 (Homo sapiens) 6480464 5-(5 more ... CTD PMID:20089605 chromium atom decreases response to substance ISO PLK1 (Homo sapiens) 6480464 PLK1 protein results in decreased susceptibility to Chromium CTD PMID:20089605 ciprofloxacin increases expression ISO Plk1 (Rattus norvegicus) 6480464 Ciprofloxacin results in increased expression of PLK1 protein CTD PMID:18512786 cis-caffeic acid multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA CTD PMID:19442820 cisplatin increases localization ISO PLK1 (Homo sapiens) 6480464 Cisplatin results in increased localization of PLK1 protein CTD PMID:20655883 cisplatin decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Cisplatin results in decreased expression of PLK1 protein CTD PMID:35842499 cisplatin multiple interactions EXP 6480464 NFE2L2 protein affects the reaction [Cisplatin results in decreased expression of PLK1 mRNA] CTD PMID:35842499 cisplatin multiple interactions ISO Plk1 (Rattus norvegicus) 6480464 Cisplatin inhibits the reaction [NFE2L2 protein results in increased expression of PLK1 mRNA] and NFE2L2 protein inhibits the reaction [Cisplatin results in decreased expression of PLK1 protein] CTD PMID:35842499 cisplatin increases expression ISO PLK1 (Homo sapiens) 6480464 Cisplatin results in increased expression of PLK1 mRNA CTD PMID:33545341 cisplatin decreases expression ISO PLK1 (Homo sapiens) 6480464 Cisplatin results in decreased expression of PLK1 mRNA CTD PMID:27594783 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of PLK1 mRNA CTD PMID:25270620 and PMID:35842499 cisplatin decreases response to substance EXP 6480464 PLK1 results in decreased susceptibility to Cisplatin CTD PMID:22006019 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of PLK1 mRNA CTD PMID:21151649 cisplatin decreases response to substance ISO PLK1 (Homo sapiens) 6480464 PLK1 protein results in decreased susceptibility to Cisplatin and PLK1 results in decreased susceptibility to Cisplatin CTD PMID:20655883 and PMID:22000864 cisplatin multiple interactions ISO PLK1 (Homo sapiens) 6480464 Cisplatin results in increased localization of [PLK1 protein co-treated with TP73 protein] more ... CTD PMID:20655883 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of PLK1 mRNA CTD PMID:17585979 clofibrate increases expression ISO Plk1 (Rattus norvegicus) 6480464 Clofibrate results in increased expression of PLK1 mRNA CTD PMID:15033592 cobalt dichloride decreases expression ISO Plk1 (Rattus norvegicus) 6480464 cobaltous chloride results in decreased expression of PLK1 mRNA CTD PMID:24386269 cobalt dichloride decreases expression ISO PLK1 (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of PLK1 mRNA CTD PMID:19320972 and PMID:19376846 copper atom multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in decreased expression of PLK1 mRNA and [NSC 689534 binds to Copper] which results in decreased expression of PLK1 mRNA CTD PMID:20971185 and PMID:30911355 copper atom increases expression ISO Plk1 (Rattus norvegicus) 6480464 Copper results in increased expression of PLK1 mRNA CTD PMID:22465980 and PMID:30556269 copper(0) multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in decreased expression of PLK1 mRNA and [NSC 689534 binds to Copper] which results in decreased expression of PLK1 mRNA CTD PMID:20971185 and PMID:30911355 copper(0) increases expression ISO Plk1 (Rattus norvegicus) 6480464 Copper results in increased expression of PLK1 mRNA CTD PMID:22465980 and PMID:30556269 copper(II) sulfate decreases expression ISO PLK1 (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of PLK1 mRNA CTD PMID:19549813 corticosterone decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Corticosterone results in decreased expression of PLK1 mRNA CTD PMID:15755911 coumarin increases phosphorylation ISO PLK1 (Homo sapiens) 6480464 coumarin results in increased phosphorylation of PLK1 protein CTD PMID:35688186 coumestrol multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:18310284 and PMID:19167446 coumestrol increases expression ISO PLK1 (Homo sapiens) 6480464 Coumestrol results in increased expression of PLK1 mRNA CTD PMID:19167446 Cuprizon increases expression ISO Plk1 (Rattus norvegicus) 6480464 Cuprizone results in increased expression of PLK1 mRNA CTD PMID:26577399 curcumin decreases expression ISO PLK1 (Homo sapiens) 6480464 Curcumin analog results in decreased expression of PLK1 mRNA CTD PMID:26409325 cyclosporin A decreases expression ISO PLK1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of PLK1 mRNA CTD PMID:20106945 more ... D-glucose increases expression EXP 6480464 Glucose results in increased expression of PLK1 mRNA CTD PMID:17178593 diallyl trisulfide decreases expression ISO PLK1 (Homo sapiens) 6480464 diallyl trisulfide results in decreased expression of PLK1 mRNA CTD PMID:34995734 diarsenic trioxide multiple interactions ISO PLK1 (Homo sapiens) 6480464 4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of PLK1 protein] more ... CTD PMID:31597699 diarsenic trioxide increases phosphorylation ISO PLK1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased phosphorylation of PLK1 protein CTD PMID:31597699 diazinon increases methylation ISO PLK1 (Homo sapiens) 6480464 Diazinon results in increased methylation of PLK1 gene CTD PMID:22964155 diazinon affects expression ISO Plk1 (Rattus norvegicus) 6480464 Diazinon affects the expression of PLK1 mRNA CTD PMID:22546817 dibenz[a,h]anthracene increases expression EXP 6480464 1 more ... CTD PMID:26377693 dibutyl phthalate decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Dibutyl Phthalate results in decreased expression of PLK1 mRNA CTD PMID:21266533 dibutyl phthalate multiple interactions ISO PLK1 (Homo sapiens) 6480464 N-methyl-delta-3 more ... CTD PMID:36828243 dibutyl phthalate increases expression ISO PLK1 (Homo sapiens) 6480464 Dibutyl Phthalate results in increased expression of PLK1 mRNA CTD PMID:36828243 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of PLK1 mRNA CTD PMID:17361019 dicrotophos increases expression ISO PLK1 (Homo sapiens) 6480464 dicrotophos results in increased expression of PLK1 mRNA CTD PMID:28302478 dieldrin affects expression ISO Plk1 (Rattus norvegicus) 6480464 Dieldrin affects the expression of PLK1 mRNA CTD PMID:22546817 diethyl maleate increases expression ISO PLK1 (Homo sapiens) 6480464 diethyl maleate results in increased expression of PLK1 mRNA CTD PMID:33545341 dioxygen decreases expression ISO PLK1 (Homo sapiens) 6480464 Oxygen deficiency results in decreased expression of PLK1 mRNA and Oxygen results in decreased expression of PLK1 mRNA CTD PMID:26516004 and PMID:27103661 dioxygen multiple interactions ISO Plk1 (Rattus norvegicus) 6480464 [dan-shen root extract co-treated with Andrographis paniculata extract] inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of PLK1 mRNA] and [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of PLK1 mRNA CTD PMID:33729688 doxorubicin decreases expression ISO PLK1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of PLK1 mRNA CTD PMID:15205334 and PMID:30031762 doxorubicin multiple interactions ISO PLK1 (Homo sapiens) 6480464 Doxorubicin affects the reaction [[Hydroxyurea co-treated with Nocodazole] affects the expression of and affects the phosphorylation of PLK1 protein] CTD PMID:31597699 Echimidine multiple interactions ISO PLK1 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of PLK1 mRNA CTD PMID:33884520 Enterolactone multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PLK1 mRNA CTD PMID:19167446 enzalutamide multiple interactions ISO PLK1 (Homo sapiens) 6480464 [enzalutamide co-treated with NVP-BHG712] results in decreased expression of PLK1 mRNA more ... CTD PMID:32184358 etoposide decreases expression EXP 6480464 Etoposide results in decreased expression of PLK1 mRNA CTD PMID:25270620 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLK1 mRNA CTD PMID:20938992 folic acid multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of PLK1 mRNA CTD PMID:24657277 FR900359 decreases phosphorylation ISO PLK1 (Homo sapiens) 6480464 FR900359 results in decreased phosphorylation of PLK1 protein CTD PMID:37730182 fulvestrant multiple interactions ISO PLK1 (Homo sapiens) 6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of PLK1 protein] more ... CTD PMID:20208560 and PMID:21367843 furan increases expression ISO Plk1 (Rattus norvegicus) 6480464 furan results in increased expression of PLK1 mRNA CTD PMID:25539665 gemcitabine affects response to substance ISO PLK1 (Homo sapiens) 6480464 PLK1 protein affects the susceptibility to Gemcitabine CTD PMID:20103597 gemcitabine decreases expression ISO PLK1 (Homo sapiens) 6480464 Gemcitabine results in decreased expression of PLK1 and Gemcitabine results in decreased expression of PLK1 mRNA CTD PMID:20103597 gemcitabine multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Gemcitabine results in decreased expression of PLK1] which results in increased susceptibility to Gemcitabine and ON 01910 promotes the reaction [PLK1 protein affects the susceptibility to Gemcitabine] CTD PMID:20103597 genistein decreases expression ISO PLK1 (Homo sapiens) 6480464 Genistein results in decreased expression of PLK1 mRNA CTD PMID:26865667 geraniol decreases expression ISO PLK1 (Homo sapiens) 6480464 geraniol results in decreased expression of PLK1 mRNA CTD PMID:27683099 glucose increases expression EXP 6480464 Glucose results in increased expression of PLK1 mRNA CTD PMID:17178593 hydrogen peroxide decreases expression ISO PLK1 (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of PLK1 mRNA CTD PMID:12414654 hydroxyurea decreases phosphorylation ISO PLK1 (Homo sapiens) 6480464 Hydroxyurea results in decreased phosphorylation of PLK1 protein CTD PMID:31597699 hydroxyurea multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Hydroxyurea co-treated with Nocodazole] affects the expression of and affects the phosphorylation of PLK1 protein and Doxorubicin affects the reaction [[Hydroxyurea co-treated with Nocodazole] affects the expression of and affects the phosphorylation of PLK1 protein] CTD PMID:31597699 indole-3-methanol multiple interactions ISO Plk1 (Rattus norvegicus) 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PLK1 mRNA CTD PMID:22129741 irinotecan decreases expression ISO PLK1 (Homo sapiens) 6480464 Irinotecan metabolite results in decreased expression of PLK1 mRNA and Irinotecan results in decreased expression of PLK1 mRNA CTD PMID:15956246 ivermectin decreases expression ISO PLK1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of PLK1 protein CTD PMID:32959892 L-ascorbic acid multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Quercetin co-treated with Ascorbic Acid] results in increased expression of PLK1 mRNA CTD PMID:17639512 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLK1 mRNA CTD PMID:20938992 Lasiocarpine multiple interactions ISO PLK1 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of PLK1 mRNA CTD PMID:33884520 leflunomide decreases expression ISO PLK1 (Homo sapiens) 6480464 leflunomide results in decreased expression of PLK1 mRNA CTD PMID:28988120 leflunomide decreases expression ISO Plk1 (Rattus norvegicus) 6480464 leflunomide results in decreased expression of PLK1 mRNA CTD PMID:24136188 lucanthone decreases expression ISO PLK1 (Homo sapiens) 6480464 Lucanthone results in decreased expression of PLK1 mRNA CTD PMID:21148553 luteolin decreases expression ISO PLK1 (Homo sapiens) 6480464 Luteolin results in decreased expression of PLK1 protein CTD PMID:22926442 menadione decreases expression ISO PLK1 (Homo sapiens) 6480464 Vitamin K 3 results in decreased expression of PLK1 mRNA CTD PMID:12414654 methotrexate multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of PLK1 mRNA CTD PMID:24657277 methotrexate decreases expression ISO PLK1 (Homo sapiens) 6480464 Methotrexate results in decreased expression of PLK1 mRNA CTD PMID:24657277 methoxyacetic acid decreases expression ISO Plk1 (Rattus norvegicus) 6480464 methoxyacetic acid results in decreased expression of PLK1 mRNA CTD PMID:9681501 methylseleninic acid affects expression ISO PLK1 (Homo sapiens) 6480464 methylselenic acid affects the expression of PLK1 mRNA CTD PMID:14617803 methylseleninic acid decreases expression ISO PLK1 (Homo sapiens) 6480464 methylselenic acid results in decreased expression of PLK1 mRNA CTD PMID:11830524 microcystin-LR increases phosphorylation ISO PLK1 (Homo sapiens) 6480464 cyanoginosin LR results in increased phosphorylation of PLK1 protein CTD PMID:26506538 mitomycin C decreases expression EXP 6480464 Mitomycin results in decreased expression of PLK1 mRNA CTD PMID:25270620 monocrotaline multiple interactions ISO PLK1 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK1 mRNA CTD PMID:33884520 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PLK1 mRNA CTD PMID:25566086 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of PLK1 mRNA CTD PMID:17854601 N-nitrosodiethylamine increases expression ISO Plk1 (Rattus norvegicus) 6480464 Diethylnitrosamine results in increased expression of PLK1 mRNA CTD PMID:25242409 N-nitrosodiethylamine multiple interactions ISO Plk1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLK mRNA and [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PLK1 mRNA CTD PMID:18164116 and PMID:22129741 N-nitrosodiethylamine multiple interactions EXP 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLK1 mRNA] CTD PMID:17854601 N-Nitrosopyrrolidine decreases expression ISO PLK1 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in decreased expression of PLK1 mRNA CTD PMID:32234424 nickel atom increases expression ISO PLK1 (Homo sapiens) 6480464 Nickel results in increased expression of PLK1 mRNA CTD PMID:19031421 nickel dichloride affects expression ISO Plk1 (Rattus norvegicus) 6480464 nickel chloride affects the expression of PLK1 mRNA CTD PMID:22546817 nocodazole multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Hydroxyurea co-treated with Nocodazole] affects the expression of and affects the phosphorylation of PLK1 protein and Doxorubicin affects the reaction [[Hydroxyurea co-treated with Nocodazole] affects the expression of and affects the phosphorylation of PLK1 protein] CTD PMID:31597699 nocodazole decreases phosphorylation ISO PLK1 (Homo sapiens) 6480464 Nocodazole results in decreased phosphorylation of PLK1 protein CTD PMID:31597699 O-methyleugenol affects expression ISO Plk1 (Rattus norvegicus) 6480464 methyleugenol affects the expression of PLK1 mRNA CTD PMID:26011634 O-methyleugenol decreases expression ISO PLK1 (Homo sapiens) 6480464 methyleugenol results in decreased expression of PLK1 mRNA CTD PMID:32234424 ochratoxin A increases expression ISO Plk1 (Rattus norvegicus) 6480464 ochratoxin A results in increased expression of PLK1 mRNA CTD PMID:16251485 more ... ochratoxin A multiple interactions EXP 6480464 TRP53 gene mutant form promotes the reaction [ochratoxin A results in increased expression of PLK1 mRNA] CTD PMID:25636497 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of PLK1 mRNA CTD PMID:25636497 oxaliplatin decreases expression ISO Plk1 (Rattus norvegicus) 6480464 oxaliplatin results in decreased expression of PLK1 mRNA CTD PMID:25729387 oxaliplatin multiple interactions ISO Plk1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PLK1 mRNA CTD PMID:25729387 oxcarbazepine decreases phosphorylation ISO Plk1 (Rattus norvegicus) 6480464 Oxcarbazepine results in decreased phosphorylation of PLK1 protein CTD PMID:34333065 ozone multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of PLK1 mRNA more ... CTD PMID:25658374 more ... ozone multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PLK1 mRNA more ... CTD PMID:32699268 paclitaxel multiple interactions ISO PLK1 (Homo sapiens) 6480464 [pifithrin co-treated with Paclitaxel] results in increased expression of PLK1 protein CTD PMID:18516295 palbociclib decreases expression ISO PLK1 (Homo sapiens) 6480464 palbociclib results in decreased expression of PLK1 mRNA CTD PMID:22869556 palbociclib multiple interactions ISO PLK1 (Homo sapiens) 6480464 palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter] and RB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]] CTD PMID:20100483 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of PLK1 mRNA CTD PMID:17562736 paracetamol decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of PLK1 mRNA CTD PMID:33387578 paraquat multiple interactions EXP 6480464 [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of PLK1 mRNA CTD PMID:28012437 paraquat increases expression ISO PLK1 (Homo sapiens) 6480464 Paraquat results in increased expression of PLK1 mRNA CTD PMID:35182771 PCB138 multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 perfluorononanoic acid decreases expression ISO PLK1 (Homo sapiens) 6480464 perfluoro-n-nonanoic acid results in decreased expression of PLK1 mRNA CTD PMID:32588087 perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of PLK1 mRNA CTD PMID:36331819 phenethyl isothiocyanate decreases expression ISO PLK1 (Homo sapiens) 6480464 phenethyl isothiocyanate results in decreased expression of PLK1 mRNA CTD PMID:26678675 phenformin decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Phenformin results in decreased expression of PLK1 mRNA CTD PMID:31324951 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of PLK1 mRNA CTD PMID:20403969 and PMID:23091169 phorbol 13-acetate 12-myristate increases expression ISO PLK1 (Homo sapiens) 6480464 Tetradecanoylphorbol Acetate results in increased expression of PLK1 mRNA CTD PMID:19031421 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of PLK1 mRNA CTD PMID:17426115 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of PLK1 mRNA CTD PMID:17950772 and PMID:23811191 pirinixic acid multiple interactions EXP 6480464 PPARA protein promotes the reaction [pirinixic acid results in increased expression of PLK1 mRNA] CTD PMID:17950772 pirinixic acid increases expression ISO Plk1 (Rattus norvegicus) 6480464 pirinixic acid results in increased expression of PLK1 mRNA CTD PMID:19162173 pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of PLK1 mRNA CTD PMID:22698814 promethazine decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Promethazine results in decreased expression of PLK1 mRNA CTD PMID:26011634 propanal decreases expression ISO PLK1 (Homo sapiens) 6480464 propionaldehyde results in decreased expression of PLK1 mRNA CTD PMID:26079696 quercetin multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Quercetin co-treated with Ascorbic Acid] results in increased expression of PLK1 mRNA CTD PMID:17639512 quercetin decreases expression ISO PLK1 (Homo sapiens) 6480464 Quercetin results in decreased expression of PLK mRNA and Quercetin results in decreased expression of PLK1 mRNA CTD PMID:15309432 and PMID:21632981 resveratrol decreases expression ISO PLK1 (Homo sapiens) 6480464 resveratrol results in decreased expression of PLK1 mRNA CTD PMID:15767336 resveratrol multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of PLK1 mRNA CTD PMID:19167446 riddelliine multiple interactions ISO PLK1 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK1 mRNA CTD PMID:33884520 rotenone decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Rotenone results in decreased expression of PLK1 mRNA CTD PMID:28374803 rotenone increases expression ISO PLK1 (Homo sapiens) 6480464 Rotenone results in increased expression of PLK1 mRNA CTD PMID:33512557 SB 431542 multiple interactions ISO PLK1 (Homo sapiens) 6480464 [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of PLK1 protein CTD PMID:37664457 serpentine asbestos increases expression ISO PLK1 (Homo sapiens) 6480464 Asbestos and Serpentine results in increased expression of PLK1 mRNA CTD PMID:24160326 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of PLK1 mRNA CTD PMID:29341224 silver atom decreases expression EXP 6480464 Silver results in decreased expression of PLK1 mRNA CTD PMID:27131904 silver(0) decreases expression EXP 6480464 Silver results in decreased expression of PLK1 mRNA CTD PMID:27131904 silver(1+) nitrate decreases expression ISO PLK1 (Homo sapiens) 6480464 Silver Nitrate analog results in decreased expression of PLK1 mRNA CTD PMID:22831968 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of PLK1 mRNA CTD PMID:16014739 sodium arsenite increases expression ISO PLK1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of PLK1 mRNA CTD PMID:28595984 more ... sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of PLK1 mRNA CTD PMID:31558096 sulforaphane increases expression ISO PLK1 (Homo sapiens) 6480464 sulforaphane results in increased expression of PLK1 mRNA CTD PMID:31838189 sunitinib decreases expression ISO PLK1 (Homo sapiens) 6480464 Sunitinib results in decreased expression of PLK1 mRNA CTD PMID:31533062 tamoxifen multiple interactions ISO PLK1 (Homo sapiens) 6480464 Tamoxifen inhibits the reaction [Estradiol results in increased expression of PLK1 protein] CTD PMID:20208560 tebufenpyrad increases expression ISO PLK1 (Homo sapiens) 6480464 4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of PLK1 mRNA CTD PMID:33512557 tert-butyl hydroperoxide decreases expression ISO PLK1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased expression of PLK1 mRNA CTD PMID:12414654 tert-butyl hydroperoxide increases expression EXP 6480464 tert-Butylhydroperoxide results in increased expression of PLK1 mRNA CTD PMID:15003993 testosterone multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of PLK1 mRNA CTD PMID:21592394 testosterone decreases expression ISO PLK1 (Homo sapiens) 6480464 Testosterone results in decreased expression of PLK1 mRNA CTD PMID:21592394 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of PLK1 mRNA CTD PMID:17484886 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of PLK1 mRNA CTD PMID:27339419 more ... tetrachloromethane multiple interactions EXP 6480464 PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PLK1 mRNA] CTD PMID:16006527 thapsigargin multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in increased expression of PLK1 mRNA more ... CTD PMID:19442820 thapsigargin increases expression ISO PLK1 (Homo sapiens) 6480464 Thapsigargin results in increased expression of PLK1 mRNA CTD PMID:19442820 thioacetamide increases expression ISO Plk1 (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of PLK1 mRNA CTD PMID:22659510 more ... thioacetamide affects expression ISO Plk1 (Rattus norvegicus) 6480464 Thioacetamide affects the expression of PLK1 mRNA CTD PMID:26011634 titanium dioxide affects activity EXP 6480464 titanium dioxide affects the activity of PLK1 protein CTD PMID:19695278 titanium dioxide increases expression ISO Plk1 (Rattus norvegicus) 6480464 titanium dioxide results in increased expression of PLK1 mRNA CTD PMID:30012374 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of PLK1 mRNA CTD PMID:23557971 toluene 2,4-diisocyanate increases expression EXP 6480464 Toluene 2 and 4-Diisocyanate results in increased expression of PLK1 mRNA CTD PMID:21404309 topotecan decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Topotecan results in decreased expression of PLK1 mRNA CTD PMID:25729387 topotecan multiple interactions ISO Plk1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PLK1 mRNA CTD PMID:25729387 trans-caffeic acid multiple interactions ISO PLK1 (Homo sapiens) 6480464 [Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA CTD PMID:19442820 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of PLK1 mRNA CTD PMID:25549359 trichloroethene decreases expression ISO Plk1 (Rattus norvegicus) 6480464 Trichloroethylene results in decreased expression of PLK1 mRNA CTD PMID:33387578 trichostatin A affects expression ISO PLK1 (Homo sapiens) 6480464 trichostatin A affects the expression of PLK1 mRNA CTD PMID:28542535 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of PLK1 mRNA CTD PMID:19042947 Triptolide increases expression ISO Plk1 (Rattus norvegicus) 6480464 triptolide results in increased expression of PLK1 mRNA CTD PMID:23639586 troglitazone decreases expression ISO PLK1 (Homo sapiens) 6480464 troglitazone results in decreased expression of PLK1 mRNA CTD PMID:19140230 trovafloxacin decreases expression EXP 6480464 trovafloxacin results in decreased expression of PLK1 mRNA CTD PMID:35537566 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of PLK1 mRNA CTD PMID:17292431 valproic acid decreases expression ISO PLK1 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of PLK1 mRNA CTD PMID:22083351 and PMID:37505509 zaragozic acid A decreases expression ISO Plk1 (Rattus norvegicus) 6480464 squalestatin 1 results in decreased expression of PLK1 mRNA CTD PMID:27225895 zaragozic acid A decreases expression EXP 6480464 squalestatin 1 results in decreased expression of PLK1 mRNA CTD PMID:27225895 zoledronic acid decreases expression ISO PLK1 (Homo sapiens) 6480464 zoledronic acid results in decreased expression of PLK1 mRNA CTD PMID:20977926