Plk1 (polo like kinase 1) - Rat Genome Database

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Gene: Plk1 (polo like kinase 1) Mus musculus
Analyze
Symbol: Plk1
Name: polo like kinase 1
RGD ID: 11121
MGI Page MGI
Description: Enables protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including meiotic chromosome segregation; peptidyl-serine phosphorylation; and synaptonemal complex disassembly. Located in chromosome and microtubule cytoskeleton. Is expressed in several structures, including alimentary system; brain; early conceptus; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in urinary bladder cancer. Orthologous to human PLK1 (polo like kinase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: P; Plk; PLK-1; polo-like kinase 1; serine/threonine-protein kinase 13; serine/threonine-protein kinase PLK1; STPK; STPK13
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18552   Plk-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,758,658 - 121,769,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,758,662 - 121,769,096 (+)EnsemblGRCm39 Ensembl
GRCm387122,159,435 - 122,169,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,159,439 - 122,169,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv377129,302,951 - 129,313,389 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367121,950,641 - 121,961,011 (+)NCBIMGSCv36mm8
Celera7122,049,692 - 122,060,205 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
CGP 52608  (ISO)
choline  (EXP)
chromium atom  (ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
Enterolactone  (ISO)
enzalutamide  (ISO)
etoposide  (EXP)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
geraniol  (ISO)
glucose  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
indole-3-methanol  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
leflunomide  (ISO)
lucanthone  (ISO)
luteolin  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
mitomycin C  (EXP)
monocrotaline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nocodazole  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
oxaliplatin  (ISO)
oxcarbazepine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
promethazine  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
silver(1+) nitrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
trans-caffeic acid  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell division  (IEA)
centrosome cycle  (ISO)
establishment of mitotic spindle orientation  (ISO)
establishment of protein localization  (ISO)
female meiosis chromosome segregation  (IMP)
G2/M transition of mitotic cell cycle  (ISO)
homologous chromosome segregation  (IMP)
microtubule bundle formation  (ISO)
mitotic cell cycle  (IBA,ISO)
mitotic cytokinesis  (ISO)
mitotic G2 DNA damage checkpoint signaling  (ISO)
mitotic sister chromatid segregation  (ISO)
mitotic spindle assembly checkpoint signaling  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
nuclear membrane disassembly  (ISO)
peptidyl-serine phosphorylation  (IDA,IMP,ISO)
phosphorylation  (IEA)
polar body extrusion after meiotic divisions  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of ubiquitin protein ligase activity  (ISO)
positive regulation of ubiquitin-protein transferase activity  (ISO)
protein destabilization  (ISO)
protein localization to chromatin  (ISO)
protein localization to nuclear envelope  (ISO)
protein localization to organelle  (IDA)
protein phosphorylation  (IMP,ISO)
protein ubiquitination  (ISO)
regulation of cytokinesis  (IBA,ISO)
regulation of mitotic cell cycle  (ISO)
regulation of mitotic metaphase/anaphase transition  (ISO)
regulation of mitotic spindle assembly  (ISO)
regulation of protein binding  (IMP,ISO)
regulation of protein localization to cell cortex  (ISO)
response to antibiotic  (ISO)
synaptonemal complex disassembly  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Glowacki G, etal., Gene 2001 Sep 19;275(2):267-77.
2. Influence of neuroendocrine tumor cells on proliferation in prostatic carcinoma. Grobholz R, etal., Hum Pathol. 2005 May;36(5):562-70.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer. Nogawa M, etal., J Clin Invest. 2005 Apr;115(4):978-85. Epub 2005 Mar 10.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis. Tang L, etal., Fertil Steril. 2008 Mar 17.
13. Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma. Weichert W, etal., Br J Cancer. 2004 Feb 23;90(4):815-21.
14. Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications. Weichert W, etal., Virchows Arch. 2005 Apr;446(4):442-50. Epub 2005 Mar 23.
15. Cloning and chromosomal localization of a new member of the bHLH/PAS transcription factor family. Wolting CD and McGlade CJ, Mamm Genome 1998 Jun;9(6):463-8.
16. Overexpression of polo-like kinase 1 (PLK1) and chromosomal instability in bladder cancer. Yamamoto Y, etal., Oncology. 2006;70(3):231-7. Epub 2006 Jul 6.
Additional References at PubMed
PMID:7478607   PMID:7576608   PMID:7893599   PMID:7902533   PMID:8018557   PMID:8099445   PMID:8524282   PMID:8889548   PMID:9370299   PMID:9371520   PMID:9755171   PMID:9914375  
PMID:10349636   PMID:10585447   PMID:10594240   PMID:10640819   PMID:10679268   PMID:10681000   PMID:10873386   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11702780   PMID:11854496  
PMID:12135894   PMID:12167714   PMID:12177162   PMID:12477932   PMID:12520002   PMID:12784245   PMID:12815053   PMID:12904583   PMID:14681479   PMID:15033168   PMID:15170225   PMID:15226823  
PMID:15327787   PMID:15489334   PMID:15531365   PMID:15616186   PMID:15782199   PMID:15817462   PMID:16141072   PMID:16141073   PMID:16310175   PMID:16412419   PMID:16507989   PMID:16805859  
PMID:17342725   PMID:17366632   PMID:18022836   PMID:18331714   PMID:18583944   PMID:18621368   PMID:18794363   PMID:18799693   PMID:18827223   PMID:19001871   PMID:19307309   PMID:19376971  
PMID:19472310   PMID:20360068   PMID:20487527   PMID:20655883   PMID:21099356   PMID:21245198   PMID:21267068   PMID:21330050   PMID:21637952   PMID:21772266   PMID:21779394   PMID:21862448  
PMID:21873635   PMID:21890624   PMID:22083510   PMID:22405274   PMID:22479190   PMID:22554510   PMID:22609948   PMID:22795848   PMID:22854038   PMID:22922362   PMID:23036704   PMID:23455152  
PMID:23536525   PMID:23649868   PMID:24133254   PMID:24142876   PMID:24498222   PMID:24553289   PMID:24706748   PMID:24792116   PMID:25043184   PMID:25047839   PMID:25049273   PMID:25533956  
PMID:25565629   PMID:25658810   PMID:26174739   PMID:26185128   PMID:26317649   PMID:26410627   PMID:26654596   PMID:26919979   PMID:26949938   PMID:27102712   PMID:27113764   PMID:27179789  
PMID:27219065   PMID:27417127   PMID:27579997   PMID:27624071   PMID:27626380   PMID:27632389   PMID:27662907   PMID:27694478   PMID:27773673   PMID:27979967   PMID:28286049   PMID:28302748  
PMID:28692064   PMID:28794108   PMID:28851945   PMID:28900036   PMID:28935709   PMID:28994651   PMID:29191835   PMID:29269218   PMID:29549256   PMID:29710485   PMID:29722913   PMID:30626697  
PMID:30635555   PMID:30676316   PMID:31101859   PMID:31138677   PMID:31345937   PMID:31393265   PMID:31545409   PMID:31825833   PMID:32212159   PMID:32232159   PMID:32267211   PMID:32463161  
PMID:32541091   PMID:32554809   PMID:33106477   PMID:33376114   PMID:33561696   PMID:33615678   PMID:33901174   PMID:34050187   PMID:34107258   PMID:34605140   PMID:34746147   PMID:34851661  
PMID:34888938   PMID:35274968   PMID:35546066   PMID:35981705  


Genomics

Comparative Map Data
Plk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,758,658 - 121,769,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,758,662 - 121,769,096 (+)EnsemblGRCm39 Ensembl
GRCm387122,159,435 - 122,169,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,159,439 - 122,169,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv377129,302,951 - 129,313,389 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367121,950,641 - 121,961,011 (+)NCBIMGSCv36mm8
Celera7122,049,692 - 122,060,205 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.52NCBI
PLK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381623,678,889 - 23,690,367 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1623,677,656 - 23,690,367 (+)EnsemblGRCh38hg38GRCh38
GRCh371623,690,210 - 23,701,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,597,702 - 23,609,189 (+)NCBINCBI36Build 36hg18NCBI36
Build 341623,597,701 - 23,609,191NCBI
Celera1622,468,373 - 22,479,857 (+)NCBICelera
Cytogenetic Map16p12.2NCBI
HuRef1621,779,829 - 21,791,312 (+)NCBIHuRef
CHM1_11624,701,920 - 24,713,407 (+)NCBICHM1_1
T2T-CHM13v2.01623,954,691 - 23,966,171 (+)NCBIT2T-CHM13v2.0
Plk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21176,716,420 - 176,726,400 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,716,420 - 176,726,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,044,423 - 185,054,396 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01192,230,379 - 192,240,352 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01184,914,429 - 184,924,412 (+)NCBIRnor_WKY
Rnor_6.01192,115,990 - 192,125,969 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,115,966 - 192,125,989 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,178,259 - 199,188,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,002,811 - 181,012,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,142,728 - 181,152,656 (+)NCBI
Celera1174,424,809 - 174,434,922 (+)NCBICelera
Cytogenetic Map1q36NCBI
Plk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,206,353 - 2,217,231 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554932,206,353 - 2,217,231 (+)NCBIChiLan1.0ChiLan1.0
PLK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11623,928,773 - 23,940,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1623,928,773 - 23,940,779 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01614,420,972 - 14,432,821 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PLK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1622,165,338 - 22,176,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl622,165,338 - 22,176,441 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha623,732,161 - 23,743,926 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0622,309,120 - 22,320,926 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl622,309,120 - 22,341,941 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1622,112,754 - 22,124,540 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0622,014,857 - 22,026,662 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0622,410,301 - 22,422,125 (-)NCBIUU_Cfam_GSD_1.0
Plk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,223,455 - 120,234,564 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365018,321,415 - 8,332,414 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl322,537,831 - 22,552,380 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1322,537,814 - 22,550,901 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,388,957 - 21,408,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl521,396,204 - 21,410,718 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660688,388,349 - 8,407,454 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247828,811,616 - 8,826,749 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247828,811,593 - 8,823,060 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
UniSTS:235166  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387122,168,883 - 122,169,498UniSTSGRCm38
GRCm38535,555,493 - 35,555,881UniSTSGRCm38
MGSCv377129,312,397 - 129,313,012UniSTSGRCm37
MGSCv37535,898,142 - 35,898,530UniSTSGRCm37
Celera7122,059,208 - 122,059,828UniSTS
Celera533,028,514 - 33,028,902UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map7F3UniSTS
cM Map518.0UniSTS
cM Map759.0UniSTS
Plk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38535,553,824 - 35,554,782UniSTSGRCm38
MGSCv37535,896,473 - 35,897,431UniSTSGRCm37
Celera533,026,845 - 33,027,803UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map5B3UniSTS
cM Map759.0UniSTS
cM Map759.0UniSTS
cM Map518.0UniSTS
Plk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387122,169,096 - 122,169,480UniSTSGRCm38
MGSCv377129,312,610 - 129,312,994UniSTSGRCm37
Celera7122,059,426 - 122,059,810UniSTS
Cytogenetic Map7F3UniSTS
cM Map759.0UniSTS
Plk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387122,169,205 - 122,169,480UniSTSGRCm38
MGSCv377129,312,719 - 129,312,994UniSTSGRCm37
Celera7122,059,535 - 122,059,810UniSTS
Cytogenetic Map7F3UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7115699235128501724Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7117750722127967336Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
1558745Tsiq1_mT-cell secretion of IL-4 QTL 1 (mouse)Not determined7119485219125141349Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir100mmu-miR-100-5pOncomiRDBexternal_infoNANA23151088
Mir100mmu-miR-100-5pOncomiRDBexternal_infoNANA22249248
Mir100mmu-miR-100-5pOncomiRDBexternal_infoNANA22246341
Mir100mmu-miR-100-5pOncomiRDBexternal_infoNANA22120675
Mir100mmu-miR-100-5pOncomiRDBexternal_infoNANA19739117

Predicted Target Of
Summary Value
Count of predictions:241
Count of miRNA genes:214
Interacting mature miRNAs:228
Transcripts:ENSMUST00000033154
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG065076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ072470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U73033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X90726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000033154   ⟹   ENSMUSP00000033154
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,758,662 - 121,769,096 (+)Ensembl
GRCm38.p6 Ensembl7122,159,439 - 122,169,873 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205901   ⟹   ENSMUSP00000146253
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,758,804 - 121,760,868 (+)Ensembl
GRCm38.p6 Ensembl7122,159,581 - 122,161,645 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206470   ⟹   ENSMUSP00000145631
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7121,758,730 - 121,763,257 (+)Ensembl
GRCm38.p6 Ensembl7122,159,507 - 122,164,034 (+)Ensembl
RefSeq Acc Id: NM_011121   ⟹   NP_035251
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397121,758,658 - 121,769,107 (+)NCBI
GRCm387122,159,435 - 122,169,884 (+)NCBI
MGSCv377129,302,951 - 129,313,389 (+)RGD
Celera7122,049,692 - 122,060,205 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035251   ⟸   NM_011121
- UniProtKB: Q07832 (UniProtKB/Swiss-Prot),   Q3TPZ2 (UniProtKB/TrEMBL),   A0A8C6IAQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000145631   ⟸   ENSMUST00000206470
RefSeq Acc Id: ENSMUSP00000146253   ⟸   ENSMUST00000205901
RefSeq Acc Id: ENSMUSP00000033154   ⟸   ENSMUST00000033154
Protein Domains
POLO box   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07832-F1-model_v2 AlphaFold Q07832 1-603 view protein structure

Promoters
RGD ID:6841792
Promoter ID:MM_KWN:52578
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   MEF_B4,   MEF_B6
Transcripts:NM_011121,   OTTMUST00000054253
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367129,301,401 - 129,302,932 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97621 AgrOrtholog
Ensembl Genes ENSMUSG00000030867 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000033154 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145631.2 UniProtKB/TrEMBL
  ENSMUSP00000146253.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033154 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000205901.2 UniProtKB/TrEMBL
  ENSMUST00000206470.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1120.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLK1_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18817 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97621 ENTREZGENE
NCBI Gene 18817 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plk1 PhenoGen
PROSITE POLO_BOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNM9_MOUSE UniProtKB/TrEMBL
  A0A0U1RQ54_MOUSE UniProtKB/TrEMBL
  A0A8C6IAQ2 ENTREZGENE
  PLK1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TPZ2 ENTREZGENE, UniProtKB/TrEMBL
  Q3UG81_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-05 Plk1  polo like kinase 1    polo-like kinase 1  Symbol and/or name change 5135510 APPROVED
2012-07-05 Plk1  polo-like kinase 1  Plk1  polo-like kinase 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED