RGD Reference Report - [Expression of human telomerase reverse transcriptase in renal cell carcinoma and its clinical significance.] - Rat Genome Database

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[Expression of human telomerase reverse transcriptase in renal cell carcinoma and its clinical significance.]

Authors: Wu, P  Zheng, SB  Zuo, Y  Tan, WL  Yao, C  Jiang, YD 
Citation: Wu P, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Feb;28(2):272-4.
RGD ID: 2291980
Pubmed: PMID:18250061   (View Abstract at PubMed)

OBJECTIVE: To investigate the expression of human telomerase reverse transcriptase (hTERT) in renal cell carcinoma (RCC) and its clinical significance. METHODS: The expression levels of hTERT mRNA and protein were detected using RT-RCR and Western blotting in 45 RCC tissues, 45 adjacent tissues and 786-0 cell line, and the associations of hTERT expression with the tumor size, clinical stage, pathological type and grade were evaluated. RESULTS: hTERT mRNA and protein was expressed at significantly higher levels in RCC tissues than in the adjacent tissues (P=0.000), and no correlation of hTERT expression was found with the tumor size, clinical stage, pathological type or grade. CONCLUSION: hTERT might serve as a diagnostic and prognostic marker for RCC, and also shed light on the new clues for gene therapy of RCC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TERTHumanrenal cell carcinoma  IEP mRNA and protein:increased expression:kidneyRGD 
TertRatrenal cell carcinoma  ISOTERT (Homo sapiens)mRNA and protein:increased expression:kidneyRGD 
TertMouserenal cell carcinoma  ISOTERT (Homo sapiens)mRNA and protein:increased expression:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tert  (telomerase reverse transcriptase)

Genes (Mus musculus)
Tert  (telomerase reverse transcriptase)

Genes (Homo sapiens)
TERT  (telomerase reverse transcriptase)


Additional Information