RGD Reference Report - Correlation between androgen receptor expression and FGF8 mRNA levels in patients with prostate cancer and benign prostatic hypertrophy. - Rat Genome Database

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Correlation between androgen receptor expression and FGF8 mRNA levels in patients with prostate cancer and benign prostatic hypertrophy.

Authors: Wang, Q  Stamp, GW  Powell, S  Abel, P  Laniado, M  Mahony, C  Lalani, EN  Waxman, J 
Citation: Wang Q, etal., J Clin Pathol. 1999 Jan;52(1):29-34.
RGD ID: 2289343
Pubmed: PMID:10343609   (View Abstract at PubMed)
PMCID: PMC501004   (View Article at PubMed Central)

AIM: To investigate the correlation between androgen receptor expression and fibroblast growth factor 8 (FGF8) mRNA levels. METHODS: 39 human prostate cancers and 14 benign prostatic hypertrophy specimens were examined immunohistochemically for androgen receptor expression and by in situ hybridisation and reverse transcription polymerase chain reaction for FGF8 expression. RESULTS: In 39 tumours there was a statistically significant negative correlation between tumour grade and FGF8 expression and a positive correlation between FGF8 and androgen receptor expression. All 14 benign hypertrophy specimens expressed moderate to high levels of FGF8 and androgen receptor. CONCLUSIONS: Loss of FGF8 may be a factor involved in the development of prostatic cancer.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
FGF8Humanprostatic hypertrophy  IEP mRNA:increased expression:prostateRGD 
Fgf8Ratprostatic hypertrophy  ISOFGF8 (Homo sapiens) RGD 
Fgf8Mouseprostatic hypertrophy  ISOFGF8 (Homo sapiens) RGD 
FGF8HumanProstatic Neoplasms disease_progressionIEP mRNA:decreased expression:prostate:expression negatively correlated with Gleason grade (p = 0.02)RGD 
Fgf8RatProstatic Neoplasms disease_progressionISOFGF8 (Homo sapiens) RGD 
Fgf8MouseProstatic Neoplasms disease_progressionISOFGF8 (Homo sapiens) RGD 


Genes (Rattus norvegicus)
Fgf8  (fibroblast growth factor 8)

Genes (Mus musculus)
Fgf8  (fibroblast growth factor 8)

Genes (Homo sapiens)
FGF8  (fibroblast growth factor 8)