RGD Reference Report - [The expression and significance of the angiopoietin-1 in the kidney of diabetic rats] - Rat Genome Database

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[The expression and significance of the angiopoietin-1 in the kidney of diabetic rats]

Authors: Yang, YB  Chen, ZJ  Liu, F  Huang, SM 
Citation: Yang YB, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jan;38(1):93-6, 104.
RGD ID: 1626163
Pubmed: PMID:17294737   (View Abstract at PubMed)

OBJECTIVE: To explore the expression and significance of angiopoietin-1 (Ang-1) in the renal tissue of diabetic rats. METHODS: The SD rats were divided into the diabetic and control groups. The diabetic group was treated by streptozotocin. The expression of Ang-1 in renal tissue was detected by RT-PCR and immunohisochemistry at 2, 4, 8, 12, 16, 20 and 24 weeks. The level of Ang-1 was quantified by computer image analysis. The relationship between Ang-1 and the index of renal damage including renal/body weight, urinary protein excretion, glomerular volume, and glomerular area was analyzed. RESULTS: Ang-1 mRNA in diabetic renal tissue was significantly upregulated at 4 and 8 weeks, compared with diabetic group at other time points or control group at the same time points, and then downregulated gradually after 12 weeks. The level of Ang-1 mRNA decreased significantly as compared with control group at 24 week. Ang-1 was outstandingly expressed in glomeruli. From 4-week to 24-week, the number of Ang-1 staining in diabetic glomeruli increased significantly as compared with control group, being maximal at 4 and 8 weeks, and subsequently decreased after 12 week. Ang-1 level was correlated with renal/body weight, glomerular volume, glomerular area, and urine protein excretion, respectively. CONCLUSION: The change of Ang-1, which is early upregulation and late downregulation, exists in diabetic renal tissue. The unusual expression of Ang-1 is partly connected with the renal changes of diabetic rats.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ANGPT1HumanExperimental Diabetes Mellitus  ISOAngpt1 (Rattus norvegicus) RGD 
Angpt1RatExperimental Diabetes Mellitus  IEP  RGD 
Angpt1MouseExperimental Diabetes Mellitus  ISOAngpt1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Angpt1  (angiopoietin 1)

Genes (Mus musculus)
Angpt1  (angiopoietin 1)

Genes (Homo sapiens)
ANGPT1  (angiopoietin 1)


Additional Information