RGD Reference Report - Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol. - Rat Genome Database

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Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol.

Authors: Sarov-Blat, L  Kiss, RS  Haidar, B  Kavaslar, N  Jaye, M  Bertiaux, M  Steplewski, K  Hurle, MR  Sprecher, D  McPherson, R  Marcel, YL 
Citation: Sarov-Blat L, etal., Arterioscler Thromb Vasc Biol. 2007 May;27(5):1115-22. Epub 2007 Feb 22.
RGD ID: 1625405
Pubmed: PMID:17322100   (View Abstract at PubMed)
DOI: DOI:10.1161/ATVBAHA.106.138990   (Journal Full-text)

OBJECTIVE: Reduced plasma concentrations of high-density lipoprotein-cholesterol (HDL-C) are a significant risk factor for cardiovascular disease. Mechanisms that regulate HDL-C concentrations represent an important area of investigation. METHODS AND RESULTS: Comparative transcriptome analyses of monocyte-derived macrophages (MDM) from a large population of low HDL-C subjects and age- and sex-matched controls revealed a cluster of inflammatory genes highly expressed in low HDL-C subjects. The expression levels of peroxisome proliferator activated receptor (PPAR) gamma and several antioxidant metallothionein genes were decreased in MDM from all low HDL-C groups compared with controls, as was the expression of other genes regulated by PPARgamma, including CD36, adipocyte fatty acid binding protein (FABP4), and adipophilin (ADFP). In contrast, PPARdelta expression was increased in MDM from low HDL-C groups. Quantitative RT-PCR corroborated all major findings from the microarray analysis in two separate patient cohorts. Expression of several inflammatory cytokine genes including interleukin 1beta, interleukin 8, and tumor necrosis factor alpha were highly increased in low HDL-C subjects. CONCLUSIONS: The activated proinflammatory state of monocytes and MDM in low HDL-C subjects constitutes a novel parameter of risk associated with HDL deficiency, related to altered expression of metallothionein genes and the reciprocal regulation of PPARgamma and PPARdelta.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL1BHumanhypolipoproteinemia  IEP mRNA:increased expression:macrophageRGD 
Il1bRathypolipoproteinemia  ISOIL1B (Homo sapiens)mRNA:increased expression:macrophageRGD 
Il1bMousehypolipoproteinemia  ISOIL1B (Homo sapiens)mRNA:increased expression:macrophageRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)


Additional Information