RGD Reference Report - Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Amplification of rearranged c-abl oncogenes in CML blast crisis. - Rat Genome Database

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Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Amplification of rearranged c-abl oncogenes in CML blast crisis.

Authors: Collins, SJ 
Citation: Collins SJ J Clin Invest. 1986 Nov;78(5):1392-6.
RGD ID: 1598673
Pubmed: PMID:3021820   (View Abstract at PubMed)
PMCID: PMC423842   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI112726   (Journal Full-text)

We surveyed 20 Philadelphia chromosome (Ph1) positive chronic myelogenous leukemia (CML) samples by Southern blot hybridization to determine the location of the breakpoints that occur on chromosomes 9 and 22 in the Ph1 translocation. Only 3 of 20 samples exhibited breakpoints on chromosome 9 within 18 kilobases (kb) of the v-abl homologous sequences. Mapping of these three chromosome 9 breakpoints indicates that each is at a separate location within this 18-kb region, indicating that there are no breakpoint "hot spots" in this area. In contrast, all 20 CML samples exhibited breaks on chromosome 22 within a 5.0-kb Bgl II fragment that lies within the previously described breakpoint cluster region (bcr). Several patients with CML blast crisis exhibiting multiple Ph1 chromosomes/metaphase exhibited amplified and rearranged c-abl-related fragments. These additional Ph1 chromosomes in blast crisis cells do not arise from a second, independent 9:22 translocation but rather result from a duplication of the preexisting Ph1 chromosome.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ABL1Humanchronic myeloid leukemia susceptibilityIAGP  RGD 
Abl1Mousechronic myeloid leukemia susceptibilityISOABL1 (Homo sapiens) RGD 
Abl1Ratchronic myeloid leukemia susceptibilityISOABL1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Abl1  (ABL proto-oncogene 1, non-receptor tyrosine kinase)

Genes (Mus musculus)
Abl1  (c-abl oncogene 1, non-receptor tyrosine kinase)

Genes (Homo sapiens)
ABL1  (ABL proto-oncogene 1, non-receptor tyrosine kinase)


Additional Information