RGD Reference Report - SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth. - Rat Genome Database

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SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth.

Authors: Yang, Zhaoting  Zhang, Chengye  Liu, Xingzhe  Che, Nan  Feng, Ying  Xuan, Yanhua 
Citation: Yang Z, etal., Am J Pathol. 2022 Apr;192(4):712-721. doi: 10.1016/j.ajpath.2021.12.006. Epub 2022 Jan 19.
RGD ID: 155804257
Pubmed: PMID:35063407   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ajpath.2021.12.006   (Journal Full-text)

Although glycolysis plays a pivotal role in breast cancer stem-like cell (BCSC) reprogramming, the molecular mechanisms that couple glycolysis to cancer stem-like cells remain unclear. SETD5 is a previously uncharacterized member of the histone lysine methyltransferase family. The goal of this study was to explore the mechanisms underlying the promotion of stem-like and glycolysis activation traits by SETD5. Previous studies have shown that overexpression of SETD5 in breast cancer tissues is associated positively with progression. The present study showed that SETD5 expression was enriched in BCSCs. Down-regulation of SETD5 significantly decreased BCSC properties and glycolysis in vitro and in vivo. Interestingly, SETD5 and glycolytic enzymes were accumulated in the central hypoxic regions of subcutaneous tumor tissues. Bioinformatic analysis predicted SETD5 binding to E1A binding protein p300 (EP300), and subsequently to hypoxia-inducible factor 1α (HIF-1α). The mechanistic study found that SETD5 is an upstream effector of EP300/HIF-1α. SETD5 knockdown reduced the expression of HIF-1α, hexokinase-2, and 6-phosphofructo-2-kinase in the nucleus after treatment with cobalt chloride, a chemical hypoxia mimetic agent that activates HIF-1α to accumulate in the nucleus. Therefore, SETD5 is required for glycolysis in BCSCs through binding to EP300/HIF-1α and could be a potential therapeutic target for breast cancer patients.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
SETD5Humanbreast cancer  IEP  RGD 
Setd5Ratbreast cancer  ISOSETD5 (Homo sapiens) RGD 
Setd5Mousebreast cancer  ISOSETD5 (Homo sapiens) RGD 


Genes (Rattus norvegicus)
Setd5  (SET domain containing 5)

Genes (Mus musculus)
Setd5  (SET domain containing 5)

Genes (Homo sapiens)
SETD5  (SET domain containing 5)