RGD Reference Report - FGF-21 ameliorates essential hypertension of SHR via baroreflex afferent function. - Rat Genome Database

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FGF-21 ameliorates essential hypertension of SHR via baroreflex afferent function.

Authors: Chen, Pei  Xu, Bing  Feng, Yan  Li, Ke-Xin  Liu, Zhuo  Sun, Xun  Lu, Xiao-Long  Wang, Lu-Qi  Chen, Yu-Wen  Fan, Xiong-Xiong  Yang, Xin-Ling  Wang, Ning  Qiao, Guo-Fen  Li, Bai-Yan 
Citation: Chen P, etal., Brain Res Bull. 2020 Jan;154:9-20. doi: 10.1016/j.brainresbull.2019.10.003. Epub 2019 Oct 15.
RGD ID: 155791444
Pubmed: PMID:31626954   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainresbull.2019.10.003   (Journal Full-text)

Hypertension is a common complication of metabolic abnormalities associated with cardiovascular system and characterized by sexual dimorphism in mammals. Fibroblast growth factor-21 (FGF-21) plays a critical role in metabolic-disorder related hypertension through the afferent loop of baroreflex. However, the gender difference in FGF-21-mediated blood pressure (BP) regulation via sexual dimorphic expression of FGFRs in the nodose (NG) and nucleus tractus solitarius (NTS) were not elucidated in physiological and genomic form of hypertension. The gene and protein expression of FGFRs were tested by qRT-PCR, immunoblotting and immunostaining; the serum level of FGF21 was tested using ELISA; The BP was monitored while FGF21 was nodose microinjected. The results showed that more potent BP reduction was confirmed in female vs. male rats by nodose microinjection of rhFGF-21 along with higher expression of FGFR2 and FGFR4 in the nodose compared with age-match male and ovariectomized (OVX) rats, rather than other receptor subtypes, which is consistent well with immunohistochemical analysis. Additionally, serum FGF-21 was significantly higher in female-WKY, and this level of FGF-21 was dramatically declined in spontaneous hypertensive rats (SHR) with significant down-regulation of FGFR1/R4 for male-SHR and FGFR2/FGFR4 for female-SHR, respectively. Apparently, high BP of SHR of either sex could be reduced by rhFGF-21 nodose microinjection. These data extends our current understanding that sexual-specific distribution/expression of FGF-21/FGFRs is likely to contribute at least partially to sexual dimorphism of baroreflex afferent function on BP regulation in rats. FGF-21-mdiated BP reduction sheds new light on clinical management of primary/genomic form of hypertension.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FGFR2Humanessential hypertension sexual_dimorphism ISOFgfr2 (Rattus norvegicus)mRNA more ...RGD 
Fgfr2Ratessential hypertension sexual_dimorphism IEP mRNA more ...RGD 
Fgfr2Mouseessential hypertension sexual_dimorphism ISOFgfr2 (Rattus norvegicus)mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fgfr2  (fibroblast growth factor receptor 2)

Genes (Mus musculus)
Fgfr2  (fibroblast growth factor receptor 2)

Genes (Homo sapiens)
FGFR2  (fibroblast growth factor receptor 2)


Additional Information