RGD Reference Report - Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus. - Rat Genome Database

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Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus.

Authors: Weiss, H  Bleich, A  Hedrich, HJ  Kolsch, B  Elsner, M  Jorns, A  Lenzen, S  Tiedge, M  Wedekind, D 
Citation: Weiss H, etal., Mamm Genome 2005 Jun;16(6):432-41.
RGD ID: 1547853
Pubmed: PMID:16075370   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-004-3022-8   (Journal Full-text)

The LEW.1AR1-iddm/Ztm rat is a new animal model of type 1 diabetes mellitus, which shows an autosomal recessive mode of inheritance for the diabetes-inducing gene. The aim of this study was to define predisposing loci of the diabetic syndrome by linkage analysis using microsatellite markers. A backcross population of 218 rats (BN x LEW.1AR1-iddm) x LEW.1AR1-iddm was analyzed using 157 polymorphic microsatellite markers covering the entire genome. Three genomic regions showed a significant linkage to the diabetic syndrome. The first susceptibility locus on rat Chromosome (RNO) 1 (LOD score 4.13) mapped to the region 1q51-55, which codes for potential candidate genes like Ins1 and Nkx2-3. The second susceptibility locus was also localized on RNO1 in the centromeric region 1p11 (LOD score 2.7) encompassing the Sod2 gene. The third quantitative trait loci (LOD score 2.97) was located on RNO20 within the major histocompatibility complex region. Comparative mapping revealed that the homologous regions in the human genome contain the IDDM loci 1, 5, 8, and 17. The identification of diabetes susceptibility regions of the genetically uniform LEW.1AR1-iddm rat strain will pave the way toward a detailed characterization of the loci conferring diabetes development as well as their functional relevance for the pathogenesis of type 1 diabetes mellitus.

Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

Iddm21  (Insulin dependent diabetes mellitus QTL 21)
Iddm22  (Insulin dependent diabetes mellitus QTL 22)
Iddm23  (Insulin dependent diabetes mellitus QTL 23)

BN/Ztm  (NA)
LEW.1AR1-iddm/Ztm  (NA)

Objects referenced in this article
Marker D20Ztm2 D20Ztm2 Rattus norvegicus
Marker D1Ztm2 D1Ztm2 Rattus norvegicus
Marker D1Ztm5 D1Ztm5 Rattus norvegicus
Marker D1Ztm10 D1Ztm10 Rattus norvegicus
Marker D1Ztm8 D1Ztm8 Rattus norvegicus
Marker D1Ztm7 D1Ztm7 Rattus norvegicus
Marker D1Ztm4 D1Ztm4 Rattus norvegicus
Marker D20Ztm1 D20Ztm1 Rattus norvegicus
Marker D1Ztm6 D1Ztm6 Rattus norvegicus
Marker D20Ztm3 D20Ztm3 Rattus norvegicus
Marker D7Ztm1 D7Ztm1 Rattus norvegicus
Marker D1Ztm9 D1Ztm9 Rattus norvegicus
Marker D1Ztm1 D1Ztm1 Rattus norvegicus
Marker D3Ztm2 D3Ztm2 Rattus norvegicus
Marker D1Ztm3 D1Ztm3 Rattus norvegicus
Strain LEW.1AR1/Ztm null Rattus norvegicus

Additional Information