Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: LEW.1AR1-iddm/Ztm

Symbol: LEW.1AR1-iddm/Ztm
Strain: LEW.1AR1-iddm
Substrain: Ztm
RGD ID: 1578710
Citation ID: RRID:RGD_1578710
Ontology ID: RS:0001353
Alleles: Dock8m1Ztm
Also Known As: LEW.1AR1-iddm/Ztm
Type: coisogenic
Available Source: Not Available
Origination: Institute for Laboratory Animal Science, Hannover Medical School, Hanover, Germany
Description: arose through a spontaneous mutation in a congenic Lewis strain with a defined MHC haplotype (RT1.AaB/DuCu) in the intra-MHC recombinant inbred strain LEW.1AR1; mutation was discovered in Fx + 13 of the LEW.1AR1 and has been maintained as a separate strain since
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes. Arndt T, etal., Diabetologia. 2015 Dec;58(12):2800-9. doi: 10.1007/s00125-015-3757-7. Epub 2015 Sep 12.
2. The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus. Lenzen S, etal., Diabetologia. 2001 Sep;44(9):1189-96. doi: 10.1007/s001250100625.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus. Weiss H, etal., Mamm Genome 2005 Jun;16(6):432-41.

Region

Strain QTL Data
Symbol Name Trait
Iddm21 Insulin dependent diabetes mellitus QTL 21 blood glucose amount   (VT:0000188)    
Iddm22 Insulin dependent diabetes mellitus QTL 22 blood glucose amount   (VT:0000188)    
Iddm23 Insulin dependent diabetes mellitus QTL 23 blood glucose amount   (VT:0000188)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_immunology animals exhibit autoimmune destruction of pancreatic beta cells causing type 1 diabetes 1547853
strain_life_disease animals develop a type 1 diabetes syndrome around day 60 after birth as a result of a rapid autoimmune destruction of pancreatic beta cells. The diabetic syndrome in the backcross population is characterized by hyperglycemia (> 10 mmol/L), weight loss, polydypsia, polyuria, glucosuria,and ketonuria 1547853
strain_other autosomal recessive model of inheritance for diabetes susceptibility/diabetes inducing gene, hypothesized to have several diabetes susceptibility loci 1547853