RGD Reference Report - Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear factor-κB signaling pathway. - Rat Genome Database

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Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear factor-κB signaling pathway.

Authors: Xia, Jin  Wang, Feng  Wang, Liuxing  Fan, Qingxia 
Citation: Xia J, etal., Tumour Biol. 2013 Feb;34(1):317-28. doi: 10.1007/s13277-012-0553-6. Epub 2012 Oct 19.
RGD ID: 152975633
Pubmed: PMID:23079781   (View Abstract at PubMed)
DOI: DOI:10.1007/s13277-012-0553-6   (Journal Full-text)

Emerging evidence has demonstrated that high-temperature requirement protein A1 (HtrA1) appears to be involved in several important biological processes in mammals such as growth, apoptosis, embryogenesis, invasion, metastasis, and cancer and has been verified to be reduced in a variety of human tumors. However, its precise functions and molecular mechanisms in esophageal squamous cell carcinoma (ESCC) remain unclear. Here, we detected HtrA1 level in ESCC tissues and cells and investigated the biological roles of HtrA1 in ESCC. We found that expressions of HtrA1 mRNA and protein in ESCC tissues and cells were significantly lower than those in normal esophageal epithelial tissues and cells (P < 0.05). Expressions of HtrA1 mRNA and protein were closely associated with TNM staging and lymph node metastasis (P < 0.05). Additionally, the survival rate of patients with low HtrA1 level was lower than those patients with high HtrA1 level (P < 0.05). Elevated HtrA1 level markedly inhibited cell proliferation in vitro and in vivo, reduced cell invasion in vitro, and induced cell apoptosis. Notably, HtrA1 overexpression inhibited phosphorylation levels of IκBα and p65 subunit of the NF-κB signaling pathway, but increased total IκBα level, coupled with decreases of Ki-67, Bcl-2, Bcl-xL, cyclin D1, and MMP-9 proteins and increase of caspase-3 activity. Overall, these data suggest that HtrA1 may play critical roles in the tumorgenesis and progression of ESCC, and HtrA1 overexpression exerts its anti-tumor effect by blocking the NF-κB signaling pathway; thus, manipulation of HtrA1 may be an effective molecular target for ESCC treatment.




  
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Original Reference(s)
HTRA1Humanesophagus squamous cell carcinoma amelioratesIMP human gene and cells in mouse modelRGD 
HTRA1Humanesophagus squamous cell carcinoma exacerbatesIEP mRNA and protein:decreased expression:epithelium of esophagus (human)RGD 
Htra1Ratesophagus squamous cell carcinoma amelioratesISOHTRA1 (Homo sapiens)human gene and cells in mouse modelRGD 
Htra1Ratesophagus squamous cell carcinoma exacerbatesISOHTRA1 (Homo sapiens)mRNA and protein:decreased expression:epithelium of esophagus (human)RGD 
Htra1Mouseesophagus squamous cell carcinoma amelioratesISOHTRA1 (Homo sapiens)human gene and cells in mouse modelRGD 
Htra1Mouseesophagus squamous cell carcinoma exacerbatesISOHTRA1 (Homo sapiens)mRNA and protein:decreased expression:epithelium of esophagus (human)RGD 


Genes (Rattus norvegicus)
Htra1  (HtrA serine peptidase 1)

Genes (Mus musculus)
Htra1  (HtrA serine peptidase 1)

Genes (Homo sapiens)
HTRA1  (HtrA serine peptidase 1)