RGD Reference Report - Gene expression profile changes and possible molecular subtypes in differentiated-type nonkeratinizing nasopharyngeal carcinoma. - Rat Genome Database

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Gene expression profile changes and possible molecular subtypes in differentiated-type nonkeratinizing nasopharyngeal carcinoma.

Authors: Wang, Shuang  Li, Xin  Li, Zu-Guo  Lu, Juan  Fang, Wei-Yi  Ding, Yan-Qing  Yao, Kai-Tai 
Citation: Wang S, etal., Int J Cancer. 2011 Feb 15;128(4):753-62. doi: 10.1002/ijc.25392.
RGD ID: 151665334
Pubmed: PMID:20473882   (View Abstract at PubMed)
DOI: DOI:10.1002/ijc.25392   (Journal Full-text)

Nasopharyngeal carcinoma (NPC) is a human malignant tumor with a high incidence and a poor prognosis in Southern China and South-eastern Asia. In this study, we comprehensively analyzed the gene expression profiles in 24 samples of primary differentiated-type nonkeratining NPC (DNK-NPC) tissues, 24 samples of normal nasopharyngeal tissues and 4 DNK-NPC cell lines using cDNA microarray technology and bioinformatics methods. We found expression level of some genes was wildly alerted in the DNK-NPC samples. In addition, our hierarchical clustering analysis revealed 2 distinctive subtypes of gene expression patterns in DNK-NPC tissue samples. The discriminator genes were identified using a signal-to-noise (S(2)N) algorithm by permuting of the data set 10,000 times. To further characterize the clinical relevance of the tumor subtypes, we evaluated a surrogate marker, CCND2, differentially expressed between the 2 tumor subgroups by using immunohistochemistry in an independent set of 137 DNK-NPC samples. CCND2 was highly expressed in the subgroups with "aggressive" features and was associated with T classification (p = 0.006) and clinical stage (p = 0.013). Patients with high level of CCND2 expression had poorer overall survival than those with low level (p = 0.034). Our results suggest that DNK-NPC can be classified into 2 subtypes based on gene expression patterns, which can be used in determining prognosis and treatment of the tumor.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
CCND2Humannasopharynx carcinoma disease_progressionIEP  RGD 
Ccnd2Ratnasopharynx carcinoma disease_progressionISOCCND2 (Homo sapiens) RGD 
Ccnd2Mousenasopharynx carcinoma disease_progressionISOCCND2 (Homo sapiens) RGD 


Genes (Rattus norvegicus)
Ccnd2  (cyclin D2)

Genes (Mus musculus)
Ccnd2  (cyclin D2)

Genes (Homo sapiens)
CCND2  (cyclin D2)