RGD Reference Report - Genetic risk between the CACNA1I gene and schizophrenia in Chinese Uygur population. - Rat Genome Database

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Genetic risk between the CACNA1I gene and schizophrenia in Chinese Uygur population.

Authors: Xu, Wei  Liu, Yahui  Chen, Jianhua  Guo, Qingli  Liu, Ke  Wen, Zujia  Zhou, Zhaowei  Song, Zhijian  Zhou, Juan  He, Lin  Yi, Qizhong  Shi, Yongyong 
Citation: Xu W, etal., Hereditas. 2017 Jul 17;155:5. doi: 10.1186/s41065-017-0037-1. eCollection 2018.
RGD ID: 15042892
Pubmed: PMID:28725167   (View Abstract at PubMed)
PMCID: PMC5513035   (View Article at PubMed Central)
DOI: DOI:10.1186/s41065-017-0037-1   (Journal Full-text)


BACKGROUND: Schizophrenia (SCZ) is a common mental disorder with high heritability, and genetic factors play a major role in the pathogenesis. Recent researches indicated that the CACNA1I involved in calcium channels probably affect the potential pathogenesis of SCZ.
RESULTS: In this study, we attempted to investigate whether the CACNA1I gene contributes the risk to SCZ in the Uighur Chinese population, and performed a case-control study involving 985 patient samples and 1218 normal controls to analyze nine SNPs within the CACNA1I gene. Among these sites, six SNPs were significantly associated with SCZ in the allele distribution: rs132575 (adjusted P allele  = 0.039, OR = 1.159), rs713860 (adjusted P allele  = 0.039, OR = 0.792), rs738168 (adjusted P allele  = 0.039, OR = 0.785), rs136805 (adjusted P allele  = 0.014, OR = 1.212), rs5757760 (adjusted P allele  = 0.042, OR = 0.873) and rs5750871 (adjusted P allele  = 0.039, OR = 0.859). In addition, two SNPs turned to be risk factors for SCZ not only in the allele distribution, but also in the genotype distribution: rs132575 (adjusted P genotype  = 0.037) and rs136805 (adjusted P genotype  = 0.037).
CONCLUSIONS: Overall, the present study provided evidence that significant association exists between the CACNA1I gene and SCZ in the Uighur Chinese population, subsequent validation of functional analysis and genetic association studies are needed to further extend this study.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
schizophrenia  IAGP 15042892DNA:SNPs: :multipleRGD 
schizophrenia  ISOCACNA1I (Homo sapiens)15042892; 15042892DNA:SNPs: :multipleRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cacna1i  (calcium voltage-gated channel subunit alpha1 I)

Genes (Mus musculus)
Cacna1i  (calcium channel, voltage-dependent, alpha 1I subunit)

Genes (Homo sapiens)
CACNA1I  (calcium voltage-gated channel subunit alpha1 I)


Additional Information