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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1621299 | 6480464 | Ethinyl Estradiol results in increased expression of CACNA1I mRNA | CTD | PMID:29112739 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1621299 | 6480464 | ESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in increased expression of CACNA1I mRNA] | CTD | PMID:29112739 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of CACNA1I mRNA, Estradiol promotes the reaction [ESR2 protein affects the expression of CACNA1I mRNA] | CTD | PMID:20404318, PMID:30165855 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of CACNA1I mRNA | CTD | PMID:23019147 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | RGD:1621299 | 6480464 | 2 more ... | CTD | PMID:29112739 | 2,2',4,4'-Tetrabromodiphenyl ether | multiple interactions | ISO | RGD:1621299 | 6480464 | ESR1 gene mutant form inhibits the reaction [2 more ... | CTD | PMID:29112739 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1621299 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CACNA1I mRNA | CTD | PMID:29673856 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:68944 | 6480464 | Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein], Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein] | CTD | PMID:17110049 | aflatoxin B1 | decreases methylation | EXP | | 6480464 | Aflatoxin B1 results in decreased methylation of CACNA1I 3' UTR more ... | CTD | PMID:27153756, PMID:30157460 | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of CACNA1I exon | CTD | PMID:30157460 | ammonium chloride | affects expression | ISO | RGD:68944 | 6480464 | Ammonium Chloride affects the expression of CACNA1I mRNA | CTD | PMID:16483693 | androgen antagonist | multiple interactions | ISO | RGD:68944 | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | aspartame | multiple interactions | ISO | RGD:1621299 | 6480464 | [Fats more ... | CTD | PMID:23783067 | barium(0) | increases transport | EXP | | 6480464 | CACNA1I mRNA alternative form results in increased transport of Barium | CTD | PMID:11179973 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzoapyrene affects the methylation of CACNA1I promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | RGD:1621299 | 6480464 | Benzoapyrene results in decreased methylation of CACNA1I exon, Benzoapyrene results in decreased methylation of CACNA1I intron | CTD | PMID:27901495 | benzo[e]pyrene | affects methylation | EXP | | 6480464 | benzoepyrene affects the methylation of CACNA1I intron | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:68944 | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | bisphenol A | affects expression | ISO | RGD:1621299 | 6480464 | bisphenol A affects the expression of CACNA1I mRNA | CTD | PMID:25958630 | bisphenol A | decreases expression | ISO | RGD:1621299 | 6480464 | bisphenol A results in decreased expression of CACNA1I mRNA | CTD | PMID:30951980 | bisphenol A | affects expression | ISO | RGD:68944 | 6480464 | bisphenol A affects the expression of CACNA1I mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | RGD:68944 | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | bisphenol A | multiple interactions | ISO | RGD:1621299 | 6480464 | ESR2 protein affects the reaction [bisphenol A affects the expression of CACNA1I mRNA] | CTD | PMID:25958630 | bisphenol F | decreases expression | ISO | RGD:1621299 | 6480464 | bisphenol F results in decreased expression of CACNA1I mRNA | CTD | PMID:30951980 | butanal | decreases expression | EXP | | 6480464 | butyraldehyde results in decreased expression of CACNA1I mRNA | CTD | PMID:26079696 | Butylparaben | multiple interactions | ISO | RGD:68944 | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | C60 fullerene | decreases expression | ISO | RGD:68944 | 6480464 | fullerene C60 results in decreased expression of CACNA1I mRNA | CTD | PMID:19167457 | calcium atom | increases transport | ISO | RGD:68944 | 6480464 | CACNA1I protein results in increased transport of Calcium | CTD | PMID:11073957 | calcium(0) | increases transport | ISO | RGD:68944 | 6480464 | CACNA1I protein results in increased transport of Calcium | CTD | PMID:11073957 | cannabidiol | affects methylation | ISO | RGD:68944 | 6480464 | Cannabidiol affects the methylation of CACNA1I gene | CTD | PMID:30521419 | colforsin daropate hydrochloride | multiple interactions | ISO | RGD:68944 | 6480464 | Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein], Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein] | CTD | PMID:17110049 | DDE | multiple interactions | ISO | RGD:68944 | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | dexamethasone | multiple interactions | EXP | | 6480464 | [Dexamethasone co-treated with Genistein] results in increased expression of CACNA1I mRNA | CTD | PMID:25136773 | dibutyl phthalate | multiple interactions | ISO | RGD:68944 | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | enflurane | affects response to substance | ISO | RGD:68944 | 6480464 | CACNA1I protein affects the susceptibility to Enflurane | CTD | PMID:15644869 | enzacamene | multiple interactions | ISO | RGD:68944 | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | epoxiconazole | multiple interactions | ISO | RGD:68944 | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | erythromycin estolate | decreases expression | ISO | RGD:68944 | 6480464 | Erythromycin Estolate results in decreased expression of CACNA1I mRNA | CTD | PMID:24412560 | ethanol | increases expression | ISO | RGD:1621299 | 6480464 | Ethanol results in increased expression of CACNA1I mRNA | CTD | PMID:30319688 | ethanol | affects splicing | ISO | RGD:1621299 | 6480464 | Ethanol affects the splicing of CACNA1I mRNA | CTD | PMID:30319688 | etomidate | affects response to substance | ISO | RGD:68944 | 6480464 | CACNA1I protein affects the susceptibility to Etomidate | CTD | PMID:15644869 | folic acid | decreases expression | ISO | RGD:1621299 | 6480464 | Folic Acid results in decreased expression of CACNA1I mRNA | CTD | PMID:25629700 | genistein | increases expression | EXP | | 6480464 | Genistein results in increased expression of CACNA1I mRNA | CTD | PMID:23019147, PMID:25136773 | genistein | multiple interactions | EXP | | 6480464 | [Dexamethasone co-treated with Genistein] results in increased expression of CACNA1I mRNA | CTD | PMID:25136773 | irinotecan | decreases expression | EXP | | 6480464 | Irinotecan analog results in decreased expression of CACNA1I mRNA | CTD | PMID:18927307 | isoflurane | affects response to substance | ISO | RGD:68944 | 6480464 | CACNA1I protein affects the susceptibility to Isoflurane | CTD | PMID:15644869 | linuron | multiple interactions | ISO | RGD:68944 | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | methapyrilene | affects methylation | EXP | | 6480464 | Methapyrilene affects the methylation of CACNA1I intron | CTD | PMID:30157460 | Mibefradil | multiple interactions | ISO | RGD:68944 | 6480464 | Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein] | CTD | PMID:17110049 | monosodium L-glutamate | multiple interactions | ISO | RGD:1621299 | 6480464 | [Fats more ... | CTD | PMID:23783067 | N-methyl-4-phenylpyridinium | increases expression | ISO | RGD:68944 | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of CACNA1I mRNA | CTD | PMID:28801915 | nickel atom | multiple interactions | ISO | RGD:68944 | 6480464 | [nickel sulfate results in increased abundance of Nickel] which results in increased expression of CACNA1I mRNA, Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein] | CTD | PMID:17110049, PMID:31734292 | nickel sulfate | multiple interactions | ISO | RGD:68944 | 6480464 | [nickel sulfate results in increased abundance of Nickel] which results in increased expression of CACNA1I mRNA | CTD | PMID:31734292 | ozone | decreases expression | ISO | RGD:1621299 | 6480464 | Ozone results in decreased expression of CACNA1I mRNA | CTD | PMID:31626304 | paracetamol | multiple interactions | ISO | RGD:68944 | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | pentobarbital | affects response to substance | ISO | RGD:68944 | 6480464 | CACNA1I protein affects the susceptibility to Pentobarbital | CTD | PMID:15644869 | phenobarbital | affects response to substance | ISO | RGD:68944 | 6480464 | CACNA1I protein affects the susceptibility to Phenobarbital | CTD | PMID:15644869 | prochloraz | multiple interactions | ISO | RGD:68944 | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | procymidone | multiple interactions | ISO | RGD:68944 | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | propanal | decreases expression | EXP | | 6480464 | propionaldehyde results in decreased expression of CACNA1I mRNA | CTD | PMID:26079696 | propofol | affects response to substance | ISO | RGD:68944 | 6480464 | CACNA1I protein affects the susceptibility to Propofol | CTD | PMID:15644869 | raloxifene | decreases expression | ISO | RGD:1621299 | 6480464 | Raloxifene Hydrochloride results in decreased expression of CACNA1I mRNA | CTD | PMID:21228613 | silicon dioxide | decreases expression | EXP | | 6480464 | Silicon Dioxide analog results in decreased expression of CACNA1I mRNA | CTD | PMID:25895662 | tetraphene | increases expression | ISO | RGD:1621299 | 6480464 | benzaanthracene results in increased expression of CACNA1I mRNA | CTD | PMID:26377693 | thiopental | affects response to substance | ISO | RGD:68944 | 6480464 | CACNA1I protein affects the susceptibility to Thiopental | CTD | PMID:15644869 | triphenyl phosphate | multiple interactions | ISO | RGD:1621299 | 6480464 | [tris1 more ... | CTD | PMID:29112739 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of CACNA1I gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | RGD:68944 | 6480464 | Valproic Acid results in decreased expression of CACNA1I mRNA | CTD | PMID:29427782 | vinclozolin | multiple interactions | ISO | RGD:68944 | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNA1I mRNA | CTD | PMID:25607892 | |