RGD Reference Report - Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma. - Rat Genome Database

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Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma.

Authors: Yang, Er-Bin  Qin, Liu-Liang  Zhao, Yin-Nong  Zhang, Kai  Chow, Pierce 
Citation: Yang EB, etal., Int J Mol Med. 2003 Jun;11(6):773-8.
RGD ID: 14985225
Pubmed: PMID:12736721   (View Abstract at PubMed)

It was reported that 60-70% of hepatitis B virus (HBV)-negative hepatocellular carcinoma (HCC) had loss of heterozygosity (LOH) at the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) locus and this gene was mutated in 55% of these patients with LOH. In this study, genomic DNA from 29 pairs of HBV-positive HCC and corresponding non-tumor tissues was used to analyze LOH at the M6P/IGF2R locus and single deoxyguanosine deletion in this gene by PCR. Total RNA from 19 of the 29 patients was utilized to determine a 192 bp insert in the M6P/IGF2R mRNA and expression of this gene by RT-PCR. Twenty-eight of 29 (97%) HBV-positive HCC were found to be informative at the M6P/IGF2R locus but LOH at this region was only detected in 4/28 (14%) informative patients. Neither single deoxyguanosine deletion in this gene nor 192 bp insert in its mRNA occurred in these patients. Compared with corresponding non-tumor tissues, expression of the M6P/IGF2R mRNA was decreased in 13/19 (68%) HBV-positive HCC tissues, suggesting that M6P/IGF2R may be involved in HBV-associated hepatocarcinogenesis by the regulation of its expression level. In the development of HBV-associated HCC, M6P/IGF2R mutation may not be a major agent.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
IGF2RHumanhepatocellular carcinoma  IEP associated with hepatitis B virus and mRNA:decreased expression:liver:RGD 
Igf2rRathepatocellular carcinoma  ISOIGF2R (Homo sapiens)associated with hepatitis B virus and mRNA:decreased expression:liver:RGD 
Igf2rMousehepatocellular carcinoma  ISOIGF2R (Homo sapiens)associated with hepatitis B virus and mRNA:decreased expression:liver:RGD 


Genes (Rattus norvegicus)
Igf2r  (insulin-like growth factor 2 receptor)

Genes (Mus musculus)
Igf2r  (insulin-like growth factor 2 receptor)

Genes (Homo sapiens)
IGF2R  (insulin like growth factor 2 receptor)