RGD Reference Report - Augmenter of liver regeneration ameliorates renal fibrosis in rats with obstructive nephropathy. - Rat Genome Database

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Augmenter of liver regeneration ameliorates renal fibrosis in rats with obstructive nephropathy.

Authors: Chen, Guo-Tao  Zhang, Ling  Liao, Xiao-Hui  Yan, Ru-Yu  Li, Ying  Sun, Hang  Guo, Hui  Liu, Qi 
Citation: Chen GT, etal., Biosci Rep. 2014 Sep 5;34(5). pii: BSR20140038. doi: 10.1042/BSR20140038.
RGD ID: 13506791
Pubmed: PMID:24844766   (View Abstract at PubMed)
PMCID: PMC4155836   (View Article at PubMed Central)
DOI: DOI:10.1042/BSR20140038   (Journal Full-text)

Renal fibrosis is a hallmark in CKD (chronic kidney disease) and is strongly correlated to the deterioration of renal function that is characterized by tubulointerstitial fibrosis, tubular atrophy, glomerulosclerosis and disruption of the normal architecture of the kidney. ALR (augmenter of liver regeneration) is a growth factor with biological functions similar to those of HGF (hepatocyte growth factor). In this study, our results indicate that endogenous ALR is involved in the pathological progression of renal fibrosis in UUO (unilateral ureteral obstruction) rat model. Moreover, we find that administration of rhALR (recombinant human ALR) significantly alleviates renal interstitial fibrosis and reduces renal-fibrosis-related proteins in UUO rats. Further investigation reveals that rhALR suppresses the up-regulated expression of TGF-ß1 (transforming growth factor ß1) induced by UUO operation in the obstructed kidney, and inhibits Smad2 and Smad3 phosphorylation activated by the UUO-induced injury in the animal model. Therefore we suggest that ALR is involved in the progression of renal fibrosis and administration of rhALR protects the kidney against renal fibrosis by inhibition of TGF-ß/Smad activity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
renal fibrosis treatmentIDA 13506791associated with ureteral obstructionRGD 
renal fibrosis treatmentISOGFER (Homo sapiens)13506791; 13506791associated with ureteral obstructionRGD 
ureteral obstruction  ISOGfer (Rattus norvegicus)13506791; 13506791 RGD 
ureteral obstruction  IEP 13506791 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gfer  (growth factor, augmenter of liver regeneration)

Genes (Mus musculus)
Gfer  (growth factor, augmenter of liver regeneration)

Genes (Homo sapiens)
GFER  (growth factor, augmenter of liver regeneration)


Additional Information