RGD Reference Report - CXCR4 antagonist AMD3100 reverses the neurogenesis promoted by enriched environment and suppresses long-term seizure activity in adult rats of temporal lobe epilepsy. - Rat Genome Database

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CXCR4 antagonist AMD3100 reverses the neurogenesis promoted by enriched environment and suppresses long-term seizure activity in adult rats of temporal lobe epilepsy.

Authors: Zhou, Zhike  Liu, Tingting  Sun, Xiaoyu  Mu, Xiaopeng  Zhu, Gang  Xiao, Ting  Zhao, Mei  Zhao, Chuansheng 
Citation: Zhou Z, etal., Behav Brain Res. 2017 Mar 30;322(Pt A):83-91. doi: 10.1016/j.bbr.2017.01.014. Epub 2017 Jan 16.
RGD ID: 13463105
Pubmed: PMID:28104461   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbr.2017.01.014   (Journal Full-text)

It has been showed that enriched environment (EE) enhances the hippocampal neurogenesis and improves the cognitive impairments, accompanied by the increased expressions of stromal cell-derived factor-1 (SDF-1) in adult rats of temporal lobe epilepsy (TLE). We examined whether the enhanced neurogenesis and improved cognitive functions induced by EE following seizures were mediated by SDF-1/CXCR4 pathway. Therefore, we investigated the effects of the EE combined with CXCR4 antagonist AMD3100 on neurogenesis, cognitive functions and the long-term seizure activity in the TLE model. Adult rats were randomly assigned as control rats, rats treated with EE, rats subjected to status epilepticus (SE), post-SE rats treated with EE, AMD3100 or EE combined with AMD3100 respectively. We used immunofluorescence staining to analyze the hippocampal neurogenesis and Nissl staining to evaluate hippocampal damage. Electroencephalography was used to measure the frequency and mean duration of spontaneous seizures. Cognitive function was evaluated by Morris water maze test. EE treatment significantly, as well as improved cognitive impairments and decreased long-term seizure activity, and that these effects might be mediated through SDF-1/CXCR4 pathway during the chronic stage of TLE. Although AMD3100 reversed the effect of EE on neurogenesis, it did not abolish the cognitive improvement induced by EE following seizures. More importantly, EE combined with AMD3100 treatment significantly suppressed long-term seizure activity, which provided promising evidences to treat TLE.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CXCR4Humantemporal lobe epilepsy  ISOCxcr4 (Rattus norvegicus) RGD 
Cxcr4Rattemporal lobe epilepsy  IMP  RGD 
Cxcr4Mousetemporal lobe epilepsy  ISOCxcr4 (Rattus norvegicus) RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cxcr4Ratpositive regulation of dendrite extension  IMP  RGD 
Cxcr4Ratpositive regulation of neurogenesis  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcr4  (C-X-C motif chemokine receptor 4)

Genes (Mus musculus)
Cxcr4  (C-X-C motif chemokine receptor 4)

Genes (Homo sapiens)
CXCR4  (C-X-C motif chemokine receptor 4)


Additional Information