RGD Reference Report - LPS-induced neutrophilic inflammation and Bcl-2 expression in metaplastic mucous cells. - Rat Genome Database

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LPS-induced neutrophilic inflammation and Bcl-2 expression in metaplastic mucous cells.

Authors: Foster, JE  Gott, K  Schuyler, MR  Kozak, W  Tesfaigzi, Y 
Citation: Foster JE, etal., Am J Physiol Lung Cell Mol Physiol 2003 Aug;285(2):L405-14. Epub 2003 Apr 18.
RGD ID: 1298700
Pubmed: PMID:12704018   (View Abstract at PubMed)
DOI: DOI:10.1152/ajplung.00249.2002   (Journal Full-text)

Our previous studies show that Bcl-2, a regulator of apoptosis, may be involved in the reduction of mucous cell metaplasia (MCM) during recovery from inflammatory responses. The present study was to determine whether neutrophilic inflammation mediates Bcl-2 expression in mucous cells. Rats were intratracheally instilled with 50-1000 microg of LPS. The number of neutrophils recovered by bronchoalveolar lavage (BAL) increased with the dose of LPS, and the percentage of Bcl-2-expressing cells increased with the numbers of neutrophils in the BAL. Depletion of neutrophils did not reduce MCM, but the percentage of Bcl-2-positive cells increased 1.8-fold in neutrophil-depleted compared with controls. Injection of rats with bezafibrate, an inducer of cytochrome P-450, doubled the number of neutrophils in the BAL, decreased MCM twofold compared with vehicle-injected controls, and reduced Bcl-2 expression. Bcl-2 mRNA levels decreased in a tracheal epithelial cell line treated with bezafibrate. These data demonstrate that Bcl-2 expression is independent of the number of neutrophils in the BAL and that bezafibrate may directly reduce Bcl-2 expression in epithelial cells.

Objects referenced in this article
Gene Bcl2 BCL2, apoptosis regulator Rattus norvegicus

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