RGD Reference Report - Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension. - Rat Genome Database

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Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension.

Authors: Harris, Louise E  Morgan, David G  Balthasar, Nina 
Citation: Harris LE, etal., Physiol Rep. 2014 Mar 20;2(3):e00240. doi: 10.1002/phy2.240. Print 2014.
RGD ID: 12910115
Pubmed: PMID:24760503   (View Abstract at PubMed)
PMCID: PMC4002229   (View Article at PubMed Central)
DOI: DOI:10.1002/phy2.240   (Journal Full-text)

Abstract Growth hormone secretagogue receptor (GHS-R) signaling has been associated with growth hormone release, increases in food intake and pleiotropic cardiovascular effects. Recent data demonstrated that acute GHS-R antagonism leads to increases in mean arterial pressure mediated by the sympathetic nervous system in rats; a highly undesirable effect if GHS-R antagonism was to be used as a therapeutic approach to reducing food intake in an already obese, hypertensive patient population. However, our data in conscious, freely moving GHS-R deficient mice demonstrate that chronic absence of GHS-R signaling is protective against obesity-induced hypertension. GHS-R deficiency leads to reduced systolic blood pressure variability (SBPV); in response to acute high-fat diet (HFD)-feeding, increases in the sympathetic control of SBPV are suppressed in GHS-R KO mice. Our data further suggest that GHS-R signaling dampens the immediate HFD-mediated increase in spontaneous baroreflex sensitivity. In diet-induced obesity, absence of GHS-R signaling leads to reductions in obesity-mediated hypertension and tachycardia. Collectively, our findings thus suggest that chronic blockade of GHS-R signaling may not result in adverse cardiovascular effects in obesity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GHSRHumanhypertension  ISOGhsr (Mus musculus)associated with ObesityRGD 
GhsrRathypertension  ISOGhsr (Mus musculus)associated with ObesityRGD 
GhsrMousehypertension  IMP associated with ObesityRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ghsr  (growth hormone secretagogue receptor)

Genes (Mus musculus)
Ghsr  (growth hormone secretagogue receptor)

Genes (Homo sapiens)
GHSR  (growth hormone secretagogue receptor)


Additional Information