RGD Reference Report - Interleukin 6, tumour necrosis factor alpha, interleukin 1beta and interleukin 1 receptor antagonist promoter or coding gene polymorphisms in multiple myeloma.

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Interleukin 6, tumour necrosis factor alpha, interleukin 1beta and interleukin 1 receptor antagonist promoter or coding gene polymorphisms in multiple myeloma.
Authors:	Zheng, C Huang, DR Bergenbrant, S Sundblad, A Osterborg, A Bjorkholm, M Holm, G Yi, Q
Citation:	Zheng C, etal., Br J Haematol. 2000 Apr;109(1):39-45.
RGD ID:	11522764
Pubmed:	PMID:10848780 (View Abstract at PubMed)
Proinflammatory cytokines such as interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-alpha) and IL-1beta are considered to be involved in the pathogenesis of multiple myeloma (MM). In the present study, we examined a G/C polymorphism at position -174 in the promoter region of IL-6, a biallelic polymorphism at position -308 in the promoter region of TNF-alpha, the TaqI restriction fragment length polymorphism in exon 5 of IL-1beta and a variable number of identical tandem repeat polymorphisms in intron 2 of IL-1 receptor antagonist (IL-1Ra) genes. The alleles of these loci are known to influence the level of production of the cytokines and the IL-1Ra. Seventy-three patients with MM, 27 with monoclonal gammopathy of undetermined significance (MGUS) and 129 healthy individuals were included. No difference was found between patients and healthy controls or between MM and MGUS patients in the distributions of genotypes and frequencies of alleles of the IL-6 (-174), TNF-alpha (-308), IL-1beta TaqI and IL-1Ra gene polymorphisms. No associations between the polymorphisms at the loci under study and clinical factors such as age, sex, clinical stage at onset and M-protein type were observed. Our results indicate that the cytokine (IL-6, TNF-alpha and IL-1beta) and IL-Ra gene polymorphisms do not confer susceptibility to the development of MM.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
IL1RN	Human	multiple myeloma	no_association	IAGP		DNA:repeats:intron:	RGD
Il1rn	Rat	multiple myeloma	no_association	ISO	IL1RN (Homo sapiens)	DNA:repeats:intron:	RGD
Il1rn	Mouse	multiple myeloma	no_association	ISO	IL1RN (Homo sapiens)	DNA:repeats:intron:	RGD

Objects Annotated

Genes (Rattus norvegicus)

Il1rn (interleukin 1 receptor antagonist)

Genes (Mus musculus)

Il1rn (interleukin 1 receptor antagonist)

Genes (Homo sapiens)

IL1RN (interleukin 1 receptor antagonist)

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Interleukin 6, tumour necrosis factor alpha, interleukin 1beta and interleukin 1 receptor antagonist promoter or coding gene polymorphisms in multiple myeloma.