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Role of the chromobox protein CBX7 in lymphomagenesis.

Authors: Scott, CL  Gil, J  Hernando, E  Teruya-Feldstein, J  Narita, M  Martinez, D  Visakorpi, T  Mu, D  Cordon-Cardo, C  Peters, G  Beach, D  Lowe, SW 
Citation: Scott CL, etal., Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5389-94. Epub 2007 Mar 20.
Pubmed: (View Article at PubMed) PMID:17374722
DOI: Full-text: DOI:10.1073/pnas.0608721104

Chromobox 7 (CBX7) is a chromobox family protein and a component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells and can act independently of BMI-1 to repress the INK4a/ARF tumor suppressor locus. To determine whether CBX7 might be oncogenic, we examined its expression pattern in a range of normal human tissues and tumor samples. CBX7 was expressed at high levels in germinal center lymphocytes and germinal center-derived follicular lymphomas, where elevated expression correlated with high c-Myc expression and a more advanced tumor grade. By targeting Cbx7 expression to the lymphoid compartment in mice, we showed that Cbx7 can initiate T cell lymphomagenesis and cooperate with c-Myc to produce highly aggressive B cell lymphomas. Furthermore, Cbx7 repressed transcription from the Ink4a/Arf locus and acted epistatically to the Arf-p53 pathway during tumorigenesis. These data identify CBX7 as a chromobox protein causally linked to cancer development and may help explain the low frequency of INK4a/ARF mutations observed in human follicular lymphoma.


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RGD Object Information
RGD ID: 11352707
Created: 2016-07-15
Species: All species
Last Modified: 2016-07-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.