RGD Reference Report - Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression. - Rat Genome Database

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Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression.

Authors: Tang, MM  Lin, WJ  Pan, YQ  Guan, XT  Li, YC 
Citation: Tang MM, etal., Physiol Behav. 2016 Apr 19. pii: S0031-9384(16)30177-9. doi: 10.1016/j.physbeh.2016.04.034.
RGD ID: 11062144
Pubmed: PMID:27106565   (View Abstract at PubMed)
DOI: DOI:10.1016/j.physbeh.2016.04.034   (Journal Full-text)

Our previous work found that triple central lipopolysaccharide (LPS) administration could induce depressive-like behaviors and increased central pro-inflammatory cytokines mRNA, hippocampal cytokine mRNA in particular. Since several neuroinflammation-associated conditions have been reported to impair neurogenesis, in this study, we further investigated whether the neuroinflammation induced depression would be associated with hippocampal neurogenesis dysfunction. An animal model of depression induced by triple central lipopolysaccharide (LPS) administration was used. In the hippocampus, the neuroinflammatory state evoked by LPS was marked by an increased production of pro-inflammatory cytokines, including interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha. It was found that rats in the neuroinflammatory state exhibited depressive-like behaviors, including reduced saccharin preference and locomotor activity as well as increased immobility time in the tail suspension test and latency to feed in the novelty suppressed feeding test. Adult hippocampal neurogenesis was concomitantly inhibited, including decreased cell proliferation and newborn cell survival. We also demonstrated that the decreased hippocampal neurogenesis in cell proliferation was significantly correlated with the depressive-like phenotypes of decreased saccharine preference and distance travelled, the core and characteristic symptoms of depression, under neuro inflammation state. These findings provide the first evidence that hippocampal neurogenesis dysfunction is correlated with neuroinflammation-induced depression, which suggests that hippocampal neurogenesis might be one of biological mechanisms underlying depression induced by neruoinflammation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL6Humandepressive disorder  ISOIl6 (Rattus norvegicus)protein:increased expression:hippocampus (rat)RGD 
Il6Ratdepressive disorder  IEP protein:increased expression:hippocampus (rat)RGD 
Il6Mousedepressive disorder  ISOIl6 (Rattus norvegicus)protein:increased expression:hippocampus (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il6  (interleukin 6)

Genes (Mus musculus)
Il6  (interleukin 6)

Genes (Homo sapiens)
IL6  (interleukin 6)


Additional Information