RGD Reference Report - [Serum transferrin receptor in healthy children. Diagnostic yield in ferropenic and infectious anemia]. - Rat Genome Database

RGD Reference Report - [Serum transferrin receptor in healthy children. Diagnostic yield in ferropenic and infectious anemia]. - Rat Genome Database

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[Serum transferrin receptor in healthy children. Diagnostic yield in ferropenic and infectious anemia].
Authors:	Aleo Lujan, E Gil Lopez, C Gonzalez Fernandez, FA Villegas Martinez, A Valverde Moreno, F
Citation:	Aleo Lujan E, etal., An Pediatr (Barc). 2004 May;60(5):428-35.
RGD ID:	11062096
Pubmed:	PMID:15104997 (View Abstract at PubMed)
BACKGROUND: The serum transferrin receptor (TfR) presents certain advantages over other parameters of cellular iron status because it does not vary in acute or chronic diseases. OBJECTIVE: To establish reference ranges of TfR in healthy children for our laboratory, to define the distribution of this variable in children with acute illness and in those with iron deficiency, and to evaluate the diagnostic yield of TfR, the transferrin-receptor/ferritin ratio (TfR/F) and the transferrin-receptor-ferritin index (TfR-F) in distinguishing ferropenic from infectious anemia. PATIENTS AND METHODS: A descriptive, cross-sectional analysis was conducted in 132 children aged from 6 months to 16 years for a period of 18 months. The subjects were classified in three groups: healthy children, children with acute illness, and children with iron deficiency. The distribution of TfR and its diagnostic yield were evaluated. RESULTS: Of the 132 subjects, 30 were excluded because they lacked one or more of the parameters under analysis and 19 were excluded because they showed a thalassemic trait. In the 30 healthy children, the mean TfR concentration was 1.2 mg/l (SD 0.36) and the median was 1.02 (IQR 0.7-1.7). In the 32 children with acute illness, with or without anemia, TfR values were similar to those found in healthy children (p > 0.05). TfR values were higher in children with iron deficiency (21 patients; mean TfR value: 1.67 mg/l SD 0:98) than in healthy children but this difference was not statistically significant (p 0.08). The highest TfR values were found in the group with ferropenic anemia (mean TfR value: 2.13 mg/l SD 1.14) with a statistically significant difference between healthy children (p 0.04) and those with iron deficiency without anemia (p 0.01). The TfR/F ratio showed an optimal diagnostic yield in distinguishing ferropenic from acute disease anemia. If this ratio is higher than 80.7 ferropenia can be suspected as the cause of the anemia with a global value of the test of 100 % (95 % CI: 75.91-99.42). CONCLUSIONS: TfR could be useful in evaluating intracellular iron status in children. Acute disease does not alter TfR values and, in combination with ferritin, TfR offers an optimal diagnostical yield in distinguishing ferropenic from acute illness anemia.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
TFRC	Human	iron deficiency anemia		IEP		protein:increased expression:serum:	RGD
Tfrc	Rat	iron deficiency anemia		ISO	TFRC (Homo sapiens)	protein:increased expression:serum:	RGD
Tfrc	Mouse	iron deficiency anemia		ISO	TFRC (Homo sapiens)	protein:increased expression:serum:	RGD

Genes (Rattus norvegicus)


Tfrc (transferrin receptor)

Genes (Mus musculus)


Tfrc (transferrin receptor)

Genes (Homo sapiens)


TFRC (transferrin receptor)