RGD Reference Report - Survival and risk of relapse of acute lymphoblastic leukemia in a Mexican population is affected by dihydrofolate reductase gene polymorphisms. - Rat Genome Database

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Survival and risk of relapse of acute lymphoblastic leukemia in a Mexican population is affected by dihydrofolate reductase gene polymorphisms.

Authors: Gomez-Gomez, Y  Organista-Nava, J  Saavedra-Herrera, MV  Rivera-Ramirez, AB  Teran-Porcayo, MA  Del Carmen Alarcon-Romero, L  Illades-Aguiar, B  Leyva-Vazquez, MA 
Citation: Gomez-Gomez Y, etal., Exp Ther Med. 2012 Apr;3(4):665-672. Epub 2012 Jan 9.
RGD ID: 11039544
Pubmed: PMID:22969948   (View Abstract at PubMed)
PMCID: PMC3438609   (View Article at PubMed Central)
DOI: DOI:10.3892/etm.2012.447   (Journal Full-text)

Dihydrofolate reductase (DHFR) is the major target of methotrexate, a key component in childhood acute lymphoblastic leukemia (ALL) treatment. Polymorphisms in the gene coding for DHFR have been associated with adverse event treatment. This study evaluated the effect of the -A317G and C829T polymorphisms in the DHFR gene on survival and risk of relapse of ALL. Seventy patients with ALL and 100 healthy individuals were genotyped by the polymerase chain reaction-restriction fragment length polymorphism method. An association between the polymorphisms and the risk of relapse was found (p<0.05); patients with the -317G/G genotype were found to have an 8.55 (95% CI 1.84-39.70) higher chance of relapse and carriers of the 829T/T genotype had a 14.0 (95% CI 1.13-172.63) higher chance of relapse. Other variables, such as age and leukocyte count, were associated (p<0.05) with the risk of relapse of the disease. Individuals with the G/G and T/T genotype of the -A317G and C829T polymorphisms had poorer survival compared to other genotype groups (log-rank test; p<0.05). Although preliminary, these data seem to suggest a role for the DHFR polymorphisms in the risk of relapse of ALL and the mortality risk in these patients.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DHFRHumanacute lymphoblastic leukemia disease_progressionIAGP DNA:polymorphisms: :-317A>G and 829C>T (human)RGD 
DhfrRatacute lymphoblastic leukemia disease_progressionISODHFR (Homo sapiens)DNA:polymorphisms: :-317A>G and 829C>T (human)RGD 
DhfrMouseacute lymphoblastic leukemia disease_progressionISODHFR (Homo sapiens)DNA:polymorphisms: :-317A>G and 829C>T (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dhfr  (dihydrofolate reductase)

Genes (Mus musculus)
Dhfr  (dihydrofolate reductase)

Genes (Homo sapiens)
DHFR  (dihydrofolate reductase)


Additional Information