RGD Reference Report - Up-regulation of ski-interacting protein in rat brain cortex after traumatic brain injury. - Rat Genome Database

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Up-regulation of ski-interacting protein in rat brain cortex after traumatic brain injury.

Authors: Chen, J  Mao, H  Zou, H  Jin, W  Ni, L  Ke, K  Cao, M  Shi, W 
Citation: Chen J, etal., J Mol Histol. 2013 Feb;44(1):1-10. doi: 10.1007/s10735-012-9444-9. Epub 2012 Sep 11.
RGD ID: 11035237
Pubmed: PMID:22965216   (View Abstract at PubMed)
DOI: DOI:10.1007/s10735-012-9444-9   (Journal Full-text)

SKIP (Ski-interacting protein), is part of nuclear regulatory complexes and interacts with factors involved in preinitiation, splicing and polyadenylation, potentiates the activity of important transcription factors, involved in an increasing number of signaling cascades. However, its distribution and function in the central nervous system remains poorly understood. In this study, western blot analysis, RT-PCR and immunohistochemistry showed a significant up-regulation of SKIP in ipsilateral peritrauma cortex compared with the sham group. Immunofluorescent labeling indicated that SKIP was localized striking in the neurons, but not astrocytes and oligodendrocytes; co-localization of SKIP and active caspase-3 and PCNA in the ipsilateral cortex. In addition, the expression patterns of active caspase-3 and PCNA were parallel with that of SKIP. Based on our data, we speculated that SKIP might play an important role in neuronal apoptosis following TBI; and might provide a basis for the further study on its role in cell cycle re-entry in traumatic brain injury.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Injuries  ISOSnw1 (Rattus norvegicus)11035237; 11035237mRNA and protein:increased expression:cerebral cortex (rat)RGD 
Brain Injuries  IEP 11035237mRNA and protein:increased expression:cerebral cortex (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Snw1  (SNW domain containing 1)

Genes (Mus musculus)
Snw1  (SNW domain containing 1)

Genes (Homo sapiens)
SNW1  (SNW domain containing 1)


Additional Information