RGD Reference Report - Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. - Rat Genome Database

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Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice.

Authors: Neuhold, LA  Killar, L  Zhao, W  Sung, ML  Warner, L  Kulik, J  Turner, J  Wu, W  Billinghurst, C  Meijers, T  Poole, AR  Babij, P  DeGennaro, LJ 
Citation: Neuhold LA, etal., J Clin Invest. 2001 Jan;107(1):35-44.
RGD ID: 10043117
Pubmed: PMID:11134178   (View Abstract at PubMed)
PMCID: PMC198546   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI10564   (Journal Full-text)

It has been suggested that increased collagenase-3 (MMP-13) activity plays a pivotal role in the pathogenesis of osteoarthritis (OA). We have used tetracycline-regulated transcription in conjunction with a cartilage-specific promoter to target a constitutively active human MMP-13 to the hyaline cartilages and joints of transgenic mice. Postnatal expression of this transgene resulted in pathological changes in articular cartilage of the mouse joints similar to those observed in human OA. These included characteristic erosion of the articular cartilage associated with loss of proteoglycan and excessive cleavage of type II collagen by collagenase, as well as synovial hyperplasia. These results demonstrate that excessive MMP-13 activity can result in articular cartilage degradation and joint pathology of the kind observed in OA, suggesting that excessive activity of this proteinase can lead to this disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MMP13Humanosteoarthritis  IMP  RGD 
Mmp13Ratosteoarthritis  ISOMMP13 (Homo sapiens) RGD 
Mmp13Mouseosteoarthritis  ISOMMP13 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp13  (matrix metallopeptidase 13)

Genes (Mus musculus)
Mmp13  (matrix metallopeptidase 13)

Genes (Homo sapiens)
MMP13  (matrix metallopeptidase 13)


Additional Information