GWAS1619582_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1619582_H (substance-related disorder QTL GWAS1619582 (human)) Homo sapiens

Symbol: GWAS1619582_H
Name: substance-related disorder QTL GWAS1619582 (human)
RGD ID: 597523508
Trait: substance-related disorder
LOD Score: Not Available
P Value: 4.0E-9
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38588,416,702 - 88,416,703RGD_MAPPER_PIPELINEGRCh38
GRCh37587,712,519 - 87,712,520RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1619582_HHumansubstance-related disorder  IAGPrs7708715405850206Based on the MONDO term ID from GWASGWAS_CATALOGPMID:37250466


#
Reference Title
Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records


The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
6480801TMEM161B-DTTMEM161B divergent transcript58826888288436674Human
11576030LINC02060long intergenic non-protein coding RNA 206058840898288439090Human


Peak: (rs7708715)
Human AssemblyChrPosition (strand)Source
GRCh38588,416,702 - 88,416,703RGD_MAPPER_PIPELINE


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597532681GWAS1628755_Hsmoking initiation QTL GWAS1628755 (human)1e-13smoking initiation58841670288416703Human
597523508GWAS1619582_Hsubstance-related disorder QTL GWAS1619582 (human)4e-09substance-related disorder58841670288416703Human
597531681GWAS1627755_Hcannabis dependence QTL GWAS1627755 (human)3e-08cannabis dependence58841670288416703Human
597417812GWAS1513886_Hsmoking initiation QTL GWAS1513886 (human)1e-19smoking initiation58841670288416703Human



Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL
GWAS Catalog Study
Disease Trait
Study Size
Risk Allele
Risk Allele Frequency
P Value
P Value MLOG
Peak Marker
Reported Odds Ratio or Beta-coefficient
Ontology Accession
PubMed
GWAS1619582_H GCST90274726 Substance use disorder (pleiotropy) 300,789 European ancestry problematic alcohol use individuals, 270,120 European ancestry problematic tobacco use individuals, 46,351 European ancestry cannabis use disorder individuals, 30,443 European ancestry opioid use disorder individuals, 82,705 African American problematic alcohol use individuals, 9,925 African American problematic tobacco use individuals, 9,745 African American cannabis use disorder individuals, 32,088 African American opioid use disorder individuals ? NR 4E-9 8.398 rs7708715 0.003 PMID:37250466
GWAS1513886_H GCST007462 Age of smoking initiation (MTAG) up to 931,815 European ancestry individuals A 0.462 1E-19 19 rs7708715 0.0132138 smoking initiation (EFO:0005670)
 PMID:30643251
GWAS1627755_H GCST90296427 Cannabis use disorder (MTAG) 48,900 European ancestry individuals (MTAG effective sample size boosted by opioid use disorder, alcohol use disorder, smoking samples) ? NR 3E-8 7.523 rs7708715 0.0166659 cannabis dependence (EFO:0007191)
 PMID:37156939
GWAS1628755_H GCST90296430 Smoking initiation (MTAG) 632,802 European ancestry individuals (MTAG effective sample size boosted by opioid use disorder, cannabis use disorder, alcohol use disorder samples) ? NR 1E-13 13 rs7708715 0.0118638 smoking initiation (EFO:0005670)
 PMID:37156939
Database
Acc Id
Source(s)
GWAS Catalog GCST90274726 GWAS Catalog

Note Type Note Reference