GWAS1258586_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1258586_H (Graves disease QTL GWAS1258586 (human)) Homo sapiens

Symbol: GWAS1258586_H
Name: Graves disease QTL GWAS1258586 (human)
RGD ID: 597162512
Trait: Graves disease
LOD Score: Not Available
P Value: 7.0E-9
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38690,279,406 - 90,279,407RGD_MAPPER_PIPELINEGRCh38
GRCh37690,989,125 - 90,989,126RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1258586_HHumanGraves' disease  IAGPrs7754251405850206 GWAS_CATALOGPMID:34594039
GWAS1258586_HHumantoxic diffuse goiter  IAGPrs7754251405850206 GWAS_CATALOGPMID:34594039

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1258586_HHumanGraves disease  IAGPrs7754251405850206 GWAS_CATALOGPMID:34594039
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1258586_HHumanGraves disease  IAGPrs7754251405850206 GWAS_CATALOGPMID:34594039

#
Reference Title
Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records


The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1319503BACH2BTB domain and CNC homolog 268992652890296843Human


Peak: (rs7754251)
Human AssemblyChrPosition (strand)Source
GRCh38690,279,406 - 90,279,407RGD_MAPPER_PIPELINE


1 to 10 of 10 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597590683GWAS1647543_Hhypothyroidism QTL GWAS1647543 (human)1e-26hypothyroidism69027940690279407Human
597281870GWAS1377944_Hhypothyroidism QTL GWAS1377944 (human)2e-43hypothyroidism69027940690279407Human
597162512GWAS1258586_HGraves disease QTL GWAS1258586 (human)7e-09Graves disease69027940690279407Human
1298426BFD3_HBody fluid distribution QTL 3 (human)2.790.01Body fluid distributionimpedance ratio684873647110873647Human
597587415GWAS1644275_Hhypothyroidism QTL GWAS1644275 (human)2e-35hypothyroidism69027940690279407Human
597050781GWAS1146855_Hhypothyroidism QTL GWAS1146855 (human)2e-39hypothyroidism69027940690279407Human
597596021GWAS1652881_Hthyroid disease QTL GWAS1652881 (human)1e-22thyroid disease69027940690279407Human
597310305GWAS1406379_HThyroid preparation use measurement QTL GWAS1406379 (human)9e-41Thyroid preparation use measurement69027940690279407Human
597164101GWAS1260175_HHashimoto's thyroiditis QTL GWAS1260175 (human)2e-09Hashimoto's thyroiditis69027940690279407Human
597110856GWAS1206930_HThyroid preparation use measurement QTL GWAS1206930 (human)1e-39Thyroid preparation use measurement69027940690279407Human

1 to 10 of 10 rows


1 to 10 of 10 rows
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL
GWAS Catalog Study
Disease Trait
Study Size
Risk Allele
Risk Allele Frequency
P Value
P Value MLOG
Peak Marker
Reported Odds Ratio or Beta-coefficient
Ontology Accession
PubMed
GWAS1258586_H GCST90018847 Graves' disease 1,678 European ancestry cases, 456,942 European ancestry controls, 2,809 East Asian ancestry cases, 172,656 East Asian ancestry controls C NR 7E-9 8.155 rs7754251 0.1312 Graves disease (EFO:0004237)
 PMID:34594039
GWAS1644275_H GCST90475647 Hypothyroidism (PheCode 244) 62,814 European ancestry cases, 378,321 European ancestry controls G 0.4418 2E-35 34.699 rs7754251 0.07173 hypothyroidism (EFO:0004705)
 PMID:39024449
GWAS1647543_H GCST90479870 Hypothyroidism (PheCode 244) 7,603 African American or Afro-Caribbean cases, 112,167 African American or Afro-Caribbean controls, 6,082 Hispanic or Latin American cases, 52,666 Hispanic or Latin American controls, 398 East Asian ancestry cases, 6,360 East Asian ancestry controls, 62,814 European ancestry cases, 378,321 European ancestry controls G 0.4887 1E-26 26 rs7754251 0.0708 hypothyroidism (EFO:0004705)
 PMID:39024449
GWAS1146855_H GCST007073 Hypothyroidism approximately 459,000 European ancestry individuals ? NR 2E-39 38.699 rs7754251 N/A hypothyroidism (EFO:0004705)
 PMID:30595370
GWAS1652881_H GCST90475276 Thyroid problems 33,335 European ancestry cases, 282,333 European ancestry controls G 0.4425 1E-22 22 rs7754251 0.08114 thyroid disease (EFO:1000627)
 PMID:39024449
GWAS1206930_H GCST007932 Medication use (thyroid preparations) 24,832 European ancestry cases, 280,750 European ancestry controls G 0.418931 1E-39 39 rs7754251 0.12090885 Thyroid preparation use measurement (EFO:0009933)
 PMID:31015401
GWAS1260175_H GCST90018855 Hashimoto thyroiditis 15,654 European ancestry cases, 379,986 European ancestry controls, 537 East Asian ancestry cases, 172,656 East Asian ancestry controls C NR 2E-9 8.699 rs7754251 0.0986 Hashimoto's thyroiditis (EFO:0003779)
 PMID:34594039
GWAS1377944_H GCST90204167 Hypothyroidism 51,194 European ancestry cases, 443,383 European ancestry controls C NR 2E-43 42.699 rs7754251 0.1111923 hypothyroidism (EFO:0004705)
 PMID:36093044
GWAS1694511_H GCST90013791 Type 1 diabetes 15,573 European ancestry cases, 158,408 European ancestry controls G 0.4158 4E-15 14.398 rs7754251 0.89 PMID:39749473
GWAS1406379_H GCST90018990 Medication use (thyroid preparations) 24,832 European ancestry cases, 280,750 European ancestry controls, 3,103 East Asian ancestry cases, 175,623 East Asian ancestry controls C NR 9E-41 40.046 rs7754251 0.1164 Thyroid preparation use measurement (EFO:0009933)
 PMID:34594039
1 to 10 of 10 rows
Database
Acc Id
Source(s)
GWAS Catalog GCST90018847 GWAS Catalog

Note Type Note Reference