GWAS1183899_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1183899_H (rheumatoid arthritis QTL GWAS1183899 (human)) Homo sapiens

Symbol: GWAS1183899_H
Name: rheumatoid arthritis QTL GWAS1183899 (human)
RGD ID: 597087825
Trait: rheumatoid arthritis
LOD Score: Not Available
P Value: 1.0E-9
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381538,541,832 - 38,541,833RGD_MAPPER_PIPELINEGRCh38
GRCh371538,834,033 - 38,834,034RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1183899_HHumancoronary artery disease  IAGPrs8032939405850206 GWAS_CATALOGPMID:38062574
GWAS1183899_HHumanrheumatoid arthritis  IAGPrs8032939405850206 GWAS_CATALOGPMID:32723749
GWAS1183899_HHumantype 2 diabetes mellitus  IAGPrs8032939405850206Based on the MONDO term ID from GWASGWAS_CATALOGPMID:38062574

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1183899_HHumanCoronary artery atherosclerosis  IAGPrs8032939405850206 GWAS_CATALOGPMID:38062574
GWAS1183899_HHumanRheumatoid arthritis  IAGPrs8032939405850206 GWAS_CATALOGPMID:32723749
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1183899_HHumancoronary artery disease  IAGPrs8032939405850206 GWAS_CATALOGPMID:38062574
GWAS1183899_HHumanrheumatoid arthritis  IAGPrs8032939405850206 GWAS_CATALOGPMID:32723749

#
Reference Title
Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records


The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
69137RASGRP1RAS guanyl releasing protein 1153848810338564814Human


Peak: (rs8032939)
Human AssemblyChrPosition (strand)Source
GRCh381538,541,832 - 38,541,833RGD_MAPPER_PIPELINE


1 to 10 of 22 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2289410BW327_HBody weight QTL 327 (human)3.320.0001Body fat amount151998012945980129Human
597022612GWAS1118686_Hrheumatoid arthritis QTL GWAS1118686 (human)2e-17rheumatoid arthritis153854183238541833Human
597035893GWAS1131967_Htype 2 diabetes mellitus QTL GWAS1131967 (human)4e-14type 2 diabetes mellitus153854183238541833Human
597294618GWAS1390692_Htype 2 diabetes mellitus, coronary artery disease QTL GWAS1390692 (human)5e-12type 2 diabetes mellitus, coronary artery disease153854183238541833Human
1559411SCL107_HSerum cholesterol level QTL 107 (human)3.88Lipid leveltriglyceride152654355252543552Human
406961732GWAS610708_Hrheumatoid arthritis QTL GWAS610708 (human)0.000009rheumatoid arthritis153854183238541833Human
406961991GWAS610967_Hrheumatoid arthritis QTL GWAS610967 (human)2e-18rheumatoid arthritis153854183238541833Human
597087825GWAS1183899_Hrheumatoid arthritis QTL GWAS1183899 (human)1e-09type 2 diabetes mellitus, coronary artery disease153854183238541833Human
597267710GWAS1363784_Hrheumatoid arthritis QTL GWAS1363784 (human)8e-09rheumatoid arthritis153854183238541833Human
406961992GWAS610968_Hrheumatoid arthritis QTL GWAS610968 (human)3e-14rheumatoid arthritis153854183238541833Human

1 to 10 of 22 rows


1 to 14 of 14 rows
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL
GWAS Catalog Study
Disease Trait
Study Size
Risk Allele
Risk Allele Frequency
P Value
P Value MLOG
Peak Marker
Reported Odds Ratio or Beta-coefficient
Ontology Accession
PubMed
GWAS1183899_H GCST011389 Rheumatoid arthritis 4,068 Korean ancestry cases, 36,487 Korean ancestry controls ? NR 1E-9 9 rs8032939 0.86 rheumatoid arthritis (EFO:0000685)
 PMID:32723749
GWAS1118686_H GCST006048 Rheumatoid arthritis (ACPA-positive) 2,234 Korean ancestry cases, 7,065 Korean ancestry controls, 10,288 European ancestry cases, 35,502 European ancestry controls G 0.74 2E-17 16.699 rs8032939 1.1627907 rheumatoid arthritis (EFO:0000685)
 PMID:24532676
GWAS1125044_H GCST006959 Rheumatoid arthritis 916 African American cases, 1,392 African American controls, T NR 3E-16 15.523 rs8032939 0.117174 rheumatoid arthritis (EFO:0000685)
 PMID:30423114
GWAS1131967_H GCST009379 Type 2 diabetes 74,124 European ancestry cases, 824,006 European ancestry controls C 0.246 4E-14 13.398 rs8032939 1.06 PMID:30297969
GWAS1134057_H GCST006959 Rheumatoid arthritis 916 African American cases, 1,392 African American controls, T 0.75 2E-12 11.699 rs8032939 0.12131 rheumatoid arthritis (EFO:0000685)
 PMID:30423114
GWAS610708_H GCST002318 Rheumatoid arthritis up to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls C 0.6 0.000009 5.046 rs8032939 1.12 rheumatoid arthritis (EFO:0000685)
 PMID:24390342
GWAS610967_H GCST002318 Rheumatoid arthritis up to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls C 0.35 2E-18 17.699 rs8032939 1.13 rheumatoid arthritis (EFO:0000685)
 PMID:24390342
GWAS610968_H GCST002318 Rheumatoid arthritis up to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls C 0.25 3E-14 13.523 rs8032939 1.13 rheumatoid arthritis (EFO:0000685)
 PMID:24390342
GWAS1286739_H GCST90270940 Systemic lupus erythematosus (MTAG) at least 5,877 East Asian ancestry cases, at least 188,588 East Asian ancestry controls, at least 14,355 European ancestry cases, at least 505,956 European ancestry controls, at least 1,393 admixed American ancestry cases, at least 2,327 admixed American ancestry controls (MTAG boosted by autoimmune diseases samples) T NR 4E-16 15.398 rs8032939 0.073 PMID:36750564
GWAS1301322_H GCST90013534 Rheumatoid arthritis 14,361 European ancestry cases, 43,923 European ancestry controls, 8,267 East Asian ancestry cases, 244,741 East Asian ancestry controls T NR 5E-24 23.302 rs8032939 0.88 rheumatoid arthritis (EFO:0000685)
 PMID:33310728
GWAS1363784_H GCST90131437 Rheumatoid arthritis 26,612 European ancestry cases, 869,454 European ancestry controls, 4,701 cases, 125,923 controls T 0.75 8E-9 8.097 rs8032939 0.93 rheumatoid arthritis (EFO:0000685)
 PMID:35470158
GWAS1366362_H GCST90131438 Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) 14,551 European ancestry cases, 846,260 European ancestry controls, 3,468 cases, 145,344 controls T 0.75 0.000002 5.699 rs8032939 0.94 rheumatoid arthritis (EFO:0000685)
ACPA-positive rheumatoid arthritis (EFO:0009459)
rheumatoid factor seropositivity measurement (EFO:0007791)
 PMID:35470158
GWAS1390692_H GCST90451698 Type 2 diabetes mellitus or coronary artery disease (pleiotropy) 74,124 European ancestry type 2 diabetes cases, 181,522 European ancestry coronary artery disease cases, 1,808,174 European ancestry controls ? NR 5E-12 11.302 rs8032939 N/A coronary artery disease (EFO:0001645)
 PMID:38062574
None Available GCST90451699 Type 2 diabetes mellitus adjusted for BMI or coronary artery disease (pleiotropy) 50,409 European ancestry type 2 diabetes adjusted for BMI cases, 181,522 European ancestry coronary artery disease cases, 1,508,065 European ancestry controls ? NR 1E-9 9 rs8032939 N/A coronary artery disease (EFO:0001645)
 PMID:38062574
1 to 14 of 14 rows
Database
Acc Id
Source(s)
GWAS Catalog GCST011389 GWAS Catalog
  GCST90451699 GWAS Catalog

Note Type Note Reference