GWAS1039530_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1039530_H (N-terminal prohormone brain natriuretic peptide measurement QTL GWAS1039530 (human)) Homo sapiens

Symbol: GWAS1039530_H
Name: N-terminal prohormone brain natriuretic peptide measurement QTL GWAS1039530 (human)
RGD ID: 407390554
Trait: N-terminal prohormone brain natriuretic peptide measurement
Measurement Type: blood NH2-terminal pro-B-type natriuretic peptide level   (CMO:0002876)    
LOD Score: Not Available
P Value: 2.0E-14
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38111,859,214 - 11,859,215RGD_MAPPER_PIPELINEGRCh38
GRCh37111,919,271 - 11,919,272RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1039530_HHumanblood NH2-terminal pro-B-type natriuretic peptide level  IAGPrs198389405850206Based on the EFO term IDGWAS_CATALOGPMID:34734498

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1039530_HHumanN-terminal prohormone brain natriuretic peptide measurement  IAGPrs198389405850206 GWAS_CATALOGPMID:34734498
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Position Markers

Peak: (rs198389)
Human AssemblyChrPosition (strand)Source
GRCh38111,859,214 - 11,859,215RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
407015634GWAS664610_Hcardiovascular disease biomarker measurement QTL GWAS664610 (human)1e-15cardiovascular disease biomarker measurement11185921411859215Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
407390554GWAS1039530_HN-terminal prohormone brain natriuretic peptide measurement QTL GWAS1039530 (human)2e-14N-terminal prohormone brain natriuretic peptide measurementblood NH2-terminal pro-B-type natriuretic peptide level (CMO:0002876)11185921411859215Human
407223345GWAS872321_HBNP measurement QTL GWAS872321 (human)1e-09BNP measurementblood B-type natriuretic peptide level (CMO:0003868)11185921411859215Human
407391421GWAS1040397_HN-terminal prohormone brain natriuretic peptide measurement QTL GWAS1040397 (human)3e-23N-terminal prohormone brain natriuretic peptide measurementblood NH2-terminal pro-B-type natriuretic peptide level (CMO:0002876)11185921411859215Human
407411071GWAS1060047_HN-terminal pro-BNP measurement QTL GWAS1060047 (human)4e-31N-terminal pro-BNP measurement11185921411859215Human
407371858GWAS1020834_Hprotein measurement QTL GWAS1020834 (human)3e-77protein measurement11185921411859215Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human
406899022GWAS547998_HNT-proBNP measurement QTL GWAS547998 (human)0.0000003NT-proBNP measurementblood NH2-terminal pro-B-type natriuretic peptide level (CMO:0002876)11185921411859215Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS547998_H GCST90085762 NT proBNP plasma levels 400 French ancestry individuals A NR 3E-7 6.523 rs198389 0.262 NT-proBNP measurement (EFO:0004745)
 PMID:35264221
GWAS664610_H GCST003298 NT-proBNP levels in acute coronary syndrome at least 3,691 European ancestry individuals, up to 29 Asian ancestry individuals, 20 African ancestry individuals G 0.425 1E-15 15 rs198389 0.153 cardiovascular disease biomarker measurement (EFO:0005278)
 PMID:26908625
GWAS872321_H GCST002736 B-type natriuretic peptide levels 2,790 Black individuals G 0.4 1E-9 9 rs198389 0.18 BNP measurement (EFO:0006920)
 PMID:25561047
GWAS1020834_H GCST90012082 N-terminal prohormone brain natriuretic peptide levels 21,758 European ancestry individuals A 0.6 3E-77 76.523 rs198389 0.2306 protein measurement (EFO:0004747)
 PMID:33067605
GWAS1039530_H GCST90095077 N-terminal prohormone brain natriuretic peptide levels 1,555 French ancestry individuals from 664 families A NR 2E-14 13.699 rs198389 0.257 N-terminal prohormone brain natriuretic peptide measurement (EFO:0010921)
 PMID:34734498
GWAS1040397_H GCST90137610 N-terminal pro-BNP levels 1,852 African American or Afro-Caribbean individuals ? NR 3E-23 22.523 rs198389 0.24 N-terminal prohormone brain natriuretic peptide measurement (EFO:0010921)
 PMID:34814699
GWAS1060047_H GCST90242015 N-terminal pro-BNP levels (NPPB.7655.11.3) 3,301 European ancestry individuals G 0.413 4E-31 30.398 rs198389 0.29 N-terminal pro-BNP measurement (EFO:0022014)
 PMID:29875488
Database Acc Id Source(s)
GWAS Catalog GCST90095077 GWAS Catalog

RGD Curation Notes
Note Type Note Reference