GWAS1029786_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1029786_H (diastolic blood pressure, systolic blood pressure QTL GWAS1029786 (human)) Homo sapiens

Symbol: GWAS1029786_H
Name: diastolic blood pressure, systolic blood pressure QTL GWAS1029786 (human)
RGD ID: 407380810
Trait: diastolic blood pressure, systolic blood pressure
Measurement Type: diastolic blood pressure   (CMO:0000005)    
systolic blood pressure   (CMO:0000004)    
LOD Score: Not Available
P Value: 9.0E-7
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381538,535,939 - 38,535,940RGD_MAPPER_PIPELINEGRCh38
GRCh371538,828,140 - 38,828,141RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1029786_HHumandiastolic blood pressure  IAGPrs8043085405850206Based on the EFO term IDGWAS_CATALOGPMID:34989438
GWAS1029786_HHumansystolic blood pressure  IAGPrs8043085405850206Based on the EFO term IDGWAS_CATALOGPMID:34989438

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1029786_HHumandiastolic blood pressure  IAGPrs8043085405850206 GWAS_CATALOGPMID:34989438
GWAS1029786_HHumansystolic blood pressure  IAGPrs8043085405850206 GWAS_CATALOGPMID:34989438
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
69137RASGRP1RAS guanyl releasing protein 1153848810338564814Human

Position Markers

Peak: (rs8043085)
Human AssemblyChrPosition (strand)Source
GRCh381538,535,939 - 38,535,940RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2289410BW327_HBody weight QTL 327 (human)3.320.0001Body fat amount151998012945980129Human
407314182GWAS963158_HThyroid preparation use measurement QTL GWAS963158 (human)2e-18Thyroid preparation use measurement153853593938535940Human
407396009GWAS1044985_HThyroid preparation use measurement QTL GWAS1044985 (human)2e-17Thyroid preparation use measurement153853593938535940Human
407380810GWAS1029786_Hdiastolic blood pressure, systolic blood pressure QTL GWAS1029786 (human)0.0000009diastolic blood pressure, systolic blood pressuresystolic blood pressure (CMO:0000004)153853593938535940Human
1559411SCL107_HSerum cholesterol level QTL 107 (human)3.88Lipid leveltriglyceride152654355252543552Human
407350944GWAS999920_Htype 2 diabetes mellitus QTL GWAS999920 (human)2e-09rheumatoid arthritis153853593938535940Human
407279050GWAS928026_Htype 2 diabetes mellitus QTL GWAS928026 (human)2e-14type 2 diabetes mellitus153853593938535940Human
1559354LDLPS4_HLow density lipoprotein particle size QTL 4 (human)2.20.019LDL particle size153479023060790230Human
2289420BW314_HBody weight QTL 314 (human)2.720.0003Body weightlean mass151998012945980129Human
1643273BW330_HBody Weight QTL 330 (human)1.050.014Body weightbody mass index152686671952866719Human
407381304GWAS1030280_Hdiastolic blood pressure, systolic blood pressure QTL GWAS1030280 (human)1e-08diastolic blood pressure, systolic blood pressuresystolic blood pressure (CMO:0000004)153853593938535940Human
407014000GWAS662976_Hrheumatoid arthritis QTL GWAS662976 (human)5e-11rheumatoid arthritis153853593938535940Human
407207766GWAS856742_Hdisease QTL GWAS856742 (human)4e-08disease153853593938535940Human
2289430BMD7_HBone mineral density QTL 7 (human)3.320.0001Bone mineral density151998012945980129Human
2299958PRSTS330_HProstate tumor susceptibility QTL 330 (human)1.020.0151Prostate tumor susceptibility153479023060790230Human
407013818GWAS662794_Hrheumatoid arthritis QTL GWAS662794 (human)2e-08autoimmune disease153853593938535940Human
1643523BW284_HBody Weight QTL 284 (human)1.950.0013Body weight152179288947792889Human
407381365GWAS1030341_Hinsomnia QTL GWAS1030341 (human)1e-12insomnia153853593938535940Human
407146811GWAS795787_Htype 2 diabetes mellitus QTL GWAS795787 (human)9e-22type 2 diabetes mellitus153853593938535940Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS662794_H GCST005569 Rheumatoid arthritis up to 13,838 European ancestry cases, up to 33,742 European ancestry controls A 0.25 2E-8 7.699 rs8043085 N/A rheumatoid arthritis (EFO:0000685)
 PMID:23143596
GWAS662976_H GCST005568 Rheumatoid arthritis (ACPA-positive) up to 9,585 European ancestry cases, up to 33,742 European ancestry controls A 0.25 5E-11 10.302 rs8043085 1.1713 rheumatoid arthritis (EFO:0000685)
 PMID:23143596
GWAS795787_H GCST010557 Type 2 diabetes 148,726 European ancestry cases, 24,646 African American cases, 8,616 Hispanic cases, 46,511 Asian ancestry cases, 965,732 European ancestry controls, 31,446 African American controls, 11,829 Hispanic controls, 169,776 Asian ancestry controls G 0.6975 9E-22 21.046 rs8043085 0.0407 PMID:32541925
GWAS856742_H GCST90267290 Number of non-cancer illnesses (standard GWA) 283,743 European ancestry individuals T NR 4E-8 7.398 rs8043085 0.03231 disease (EFO:0000408)
 PMID:37106081
GWAS928026_H GCST010118 Type 2 diabetes 77,418 East Asian cases, 356,122 East Asian controls T 0.449 2E-14 13.699 rs8043085 1.05 PMID:32499647
GWAS963158_H GCST007932 Medication use (thyroid preparations) 24,832 European ancestry cases, 280,750 European ancestry controls T 0.232174 2E-18 17.699 rs8043085 0.09480068 Thyroid preparation use measurement (EFO:0009933)
 PMID:31015401
GWAS999920_H GCST90018706 Type 2 diabetes 45,383 East Asian ancestry cases, 132,032 East Asian ancestry controls T 0.489114181 2E-9 8.699 rs8043085 0.055260904 PMID:34594039
None Available GCST90328131 Major depressive disorder (broad) 258,364 European ancestry cases, 571,252 European ancestry controls, 36,818 African ancestry cases, 161,679 African ancestry controls, 21,980 East Asian ancestry cases, 360,956 East Asian ancestry controls, 4,505 South Asian ancestry cases, 27,176 South Asian ancestry controls, 25,013 Hispanic or Latin American cases, 352,946 Hispanic or Latin American controls T 0.2584 2E-8 7.699 rs8043085 0.0192 PMID:38177345
GWAS1029786_H GCST90239828 Blood pressure (pleiotropy model 1 DBP adjusted for estimated causal effects x SBP) 757,601 European ancestry individuals, 318,891 European ancestry, African American or Afro-Caribbean, Native American ancestry, Asian ancestry individuals ? NR 9E-7 6.046 rs8043085 0.05187257 diastolic blood pressure (EFO:0006336)
systolic blood pressure (EFO:0006335)
 PMID:34989438
GWAS1030280_H GCST90239829 Blood pressure (pleiotropy model 2 SBP adjusted for estimated causal effects x DBP) 757,601 European ancestry individuals, 318,891 European ancestry, African American or Afro-Caribbean, Native American ancestry, Asian ancestry individuals ? NR 1E-8 8 rs8043085 0.107909754 diastolic blood pressure (EFO:0006336)
systolic blood pressure (EFO:0006335)
 PMID:34989438
GWAS1030341_H GCST90131903 Insomnia 390,751 European ancestry female cases, 1,018,386 European ancestry female controls T NR 1E-12 12 rs8043085 0.01 insomnia (EFO:0004698)
 PMID:35835914
None Available GCST009877 Rheumatoid arthritis 15,523 European ancestry cases, 22,308 European ancestry controls T 0.235 2E-9 8.699 rs8043085 1.1194427 rheumatoid arthritis (EFO:0000685)
 PMID:30572963
None Available GCST009873 Autoimmune traits (pleiotropy) 11,489 European ancestry cases with celiac disease, 15,523 European ancestry cases with rheumatoid arthritis, 3,477 European ancestry cases with systemic sclerosis, 6,670 European ancestry cases with type 1 diabetes, 22,308 European ancestry controls T NA 2E-8 7.699 rs8043085 N/A autoimmune disease (EFO:0005140)
 PMID:30572963
GWAS1044985_H GCST90018990 Medication use (thyroid preparations) 24,832 European ancestry cases, 280,750 European ancestry controls, 3,103 East Asian ancestry cases, 175,623 East Asian ancestry controls T NR 2E-17 16.699 rs8043085 0.0849 Thyroid preparation use measurement (EFO:0009933)
 PMID:34594039
None Available GCST90319319 Hyperthyroidism 6,442 European ancestry cases, 736,566 European ancestry controls T NR 2E-8 7.699 rs8043085 1.13 hyperthyroidism (EFO:0009189)
 PMID:39067062
Database Acc Id Source(s)
GWAS Catalog GCST90239828 GWAS Catalog

RGD Curation Notes
Note Type Note Reference