GWAS1003514_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1003514_H (serum gamma-glutamyl transferase measurement QTL GWAS1003514 (human)) Homo sapiens

Symbol: GWAS1003514_H
Name: serum gamma-glutamyl transferase measurement QTL GWAS1003514 (human)
RGD ID: 407354538
Trait: serum gamma-glutamyl transferase measurement
Measurement Type: serum gamma-glutamyltransferase activity level   (CMO:0002241)    
LOD Score: Not Available
P Value: 1.0E-40
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38116,178,825 - 16,178,826RGD_MAPPER_PIPELINEGRCh38
GRCh37116,505,320 - 16,505,321RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1003514_HHumanserum gamma-glutamyltransferase activity level  IAGPrs1497406405850206Based on the EFO term IDGWAS_CATALOGPMID:34594039

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1003514_HHumanserum gamma-glutamyl transferase measurement  IAGPrs1497406405850206 GWAS_CATALOGPMID:34594039
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Position Markers

Peak: (rs1497406)
Human AssemblyChrPosition (strand)Source
GRCh38116,178,825 - 16,178,826RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
407140359GWAS789335_Hserum gamma-glutamyl transferase measurement QTL GWAS789335 (human)3e-19serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)11617882516178826Human
407347012GWAS995988_Hserum alanine aminotransferase measurement QTL GWAS995988 (human)1e-08serum albumin measurementserum albumin level (CMO:0000550)11617882516178826Human
407390412GWAS1039388_Hserum alanine aminotransferase measurement QTL GWAS1039388 (human)3e-58serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11617882516178826Human
407144065GWAS793041_Hserum gamma-glutamyl transferase measurement QTL GWAS793041 (human)4e-08cholelithiasisserum gamma-glutamyltransferase activity level (CMO:0002241)11617882516178826Human
407399374GWAS1048350_Hlow density lipoprotein cholesterol measurement QTL GWAS1048350 (human)7e-17low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)11617882516178826Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
407357013GWAS1005989_Hserum gamma-glutamyl transferase measurement QTL GWAS1005989 (human)4e-48serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)11617882516178826Human
407260309GWAS909285_Hfree androgen index QTL GWAS909285 (human)4e-24free androgen index11617882516178826Human
407368657GWAS1017633_Hserum gamma-glutamyl transferase measurement QTL GWAS1017633 (human)1e-300serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)11617882516178826Human
407376991GWAS1025967_Hserum gamma-glutamyl transferase measurement QTL GWAS1025967 (human)1e-72serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)11617882516178826Human
407351199GWAS1000175_Hserum alanine aminotransferase measurement QTL GWAS1000175 (human)2e-66serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11617882516178826Human
407390608GWAS1039584_Hnon-high density lipoprotein cholesterol measurement QTL GWAS1039584 (human)1e-14non-high density lipoprotein cholesterol measurementblood non-high density lipoprotein cholesterol level (CMO:0003967)11617882516178826Human
407360541GWAS1009517_Hserum alanine aminotransferase measurement QTL GWAS1009517 (human)3e-12serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11617882516178826Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
407084382GWAS733358_Hserum gamma-glutamyl transferase measurement QTL GWAS733358 (human)0.0000004serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)11617882516178826Human
407390313GWAS1039289_Hserum alanine aminotransferase measurement QTL GWAS1039289 (human)7e-82serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11617882516178826Human
407391663GWAS1040639_Haspartate aminotransferase measurement QTL GWAS1040639 (human)1e-42aspartate aminotransferase measurementblood aspartate aminotransferase activity level (CMO:0000580)11617882516178826Human
407348397GWAS997373_Hserum gamma-glutamyl transferase measurement QTL GWAS997373 (human)5e-72serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11617882516178826Human
407393827GWAS1042803_Hserum albumin measurement QTL GWAS1042803 (human)7e-25serum albumin measurementserum albumin level (CMO:0000550)11617882516178826Human
407243117GWAS892093_Hbody fat percentage QTL GWAS892093 (human)1e-09body fat percentagebody fat percentage (CMO:0000302)11617882516178826Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human
407354538GWAS1003514_Hserum gamma-glutamyl transferase measurement QTL GWAS1003514 (human)1e-40serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)11617882516178826Human
407357111GWAS1006087_Hserum gamma-glutamyl transferase measurement QTL GWAS1006087 (human)4e-313serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)11617882516178826Human
407350644GWAS999620_Haspartate aminotransferase measurement QTL GWAS999620 (human)8e-45aspartate aminotransferase measurementblood aspartate aminotransferase activity level (CMO:0000580)11617882516178826Human
407359667GWAS1008643_Hurate measurement QTL GWAS1008643 (human)2e-08urate measurementblood uric acid level (CMO:0000501)11617882516178826Human
407260851GWAS909827_Hsex hormone-binding globulin measurement QTL GWAS909827 (human)2e-42sex hormone-binding globulin measurement11617882516178826Human
407394609GWAS1043585_Htotal cholesterol measurement QTL GWAS1043585 (human)6e-17total cholesterol measurementblood total cholesterol level (CMO:0000051)11617882516178826Human
407150718GWAS799694_Hserum alanine aminotransferase measurement QTL GWAS799694 (human)1e-54serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11617882516178826Human
407376116GWAS1025092_Hprotein-glutamine gamma-glutamyltransferase e measurement QTL GWAS1025092 (human)3e-35protein-glutamine gamma-glutamyltransferase e measurement11617882516178826Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS733358_H GCST007380 Gamma glutamyl transferase levels in low alcohol consumption 8,716 individuals ? NR 4E-7 6.398 rs1497406 0.0211 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:30589442
GWAS789335_H GCST001277 Liver enzyme levels (gamma-glutamyl transferase) Up to 52,350 European ancestry individuals, up to 8,739 Indian Asian ancestry individuals G 0.56 3E-19 18.523 rs1497406 3.8 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:22001757
GWAS793041_H GCST001307 Gamma glutamyl transferase levels 12,526 European ancestry individuals T 0.41 4E-8 7.398 rs1497406 0.078 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:22010049
GWAS799694_H GCST90011898 Alanine aminotransferase levels 390,812 European ancestry individuals G 0.58 1E-54 54 rs1497406 15.6 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:33547301
GWAS892093_H GCST90432179 Body fat percentage (adjusted for testosterone and SHBG) 157,937 British ancestry males ? NR 1E-9 9 rs1497406 0.11 body fat percentage (EFO:0007800)
 PMID:37867527
GWAS909285_H GCST90239823 Free androgen index 162,068 British ancestry men ? NR 4E-24 23.398 rs1497406 0.034408 free androgen index (EFO:0007005)
 PMID:36653534
GWAS909827_H GCST90239821 Sex hormone-binding globulin levels 163,363 British ancestry men ? NR 2E-42 41.699 rs1497406 0.0434901 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:36653534
GWAS995988_H GCST90129602 Chronic elevation of alanine aminotransferase (cALT) levels 95,472 European ancestry cases, 68,725 European ancestry controls A 0.426 1E-8 8 rs1497406 0.042 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:35654975
GWAS997373_H GCST90134483 Liver enzyme levels (gamma-glutamyl transferase) 5,694 African ancestry individuals, 1,988 East Asian ancestry individuals, 336,298 European ancestry individuals, 6,036 South Asian ancestry individuals ? NR 5E-72 71.302 rs1497406 N/A serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:35810165
GWAS999620_H GCST90013664 Aspartate aminotransferase levels 386,570 British ancestry individuals, 10,617 Asian or Asian British individuals, 7,426 Black or Black British individuals, 2,321 Chinese ancestry individuals ? NR 8E-45 44.097 rs1497406 0.0033 aspartate aminotransferase measurement (EFO:0004736)
 PMID:34315874
GWAS1000175_H GCST90013663 Alanine aminotransferase levels 387,859 British ancestry individuals, 10,635 Asian or Asian British individuals, 7,468 Black or Black British individuals, 2,338 Chinese ancestry individuals ? NR 2E-66 65.699 rs1497406 0.0068 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:34315874
GWAS1003514_H GCST90018734 Gamma glutamyl transpeptidase 133,471 East Asian ancestry individuals G 0.805721 1E-40 40 rs1497406 0.0586691 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:34594039
GWAS1005989_H GCST90278630 Gamma glutamyl transferase levels 92,615 Taiwanese ancestry individuals ? NR 4E-48 47.398 rs1497406 N/A serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:38116116
GWAS1006087_H GCST90018954 Gamma glutamyl transpeptidase 344,104 European ancestry individuals, 133,471 East Asian ancestry individuals G NR 4E-313 312.398 rs1497406 0.0756 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:34594039
GWAS1008643_H GCST90319904 Serum urate levels 219,768 East Asian ancestry individuals, 677,373 European ancestry individuals, 132,182 individuals A NR 2E-8 7.699 rs1497406 0.0137 urate measurement (EFO:0004531)
 PMID:38658550
GWAS1009517_H GCST90278617 Alanine aminotransferase levels 92,615 Taiwanese ancestry individuals ? NR 3E-12 11.523 rs1497406 N/A serum alanine aminotransferase measurement (EFO:0004735)
 PMID:38116116
GWAS1017633_H GCST90013407 Liver enzyme levels (gamma-glutamyl transferase) 437,194 European ancestry individuals A 0.42081 1E-300 300 rs1497406 0.0212569 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:33972514
GWAS1025092_H GCST90239636 Liver enzyme levels (gamma-glutamyl transferase) 76,131 Taiwanese ancestry individuals ? NR 3E-35 34.523 rs1497406 1.16274 protein-glutamine gamma-glutamyltransferase e measurement (EFO:0020690)
 PMID:36329257
GWAS1025967_H GCST90244011 Gamma glutamyl transferase levels 288,127 East Asian ancestry individuals G 0.8149 1E-72 72 rs1497406 0.0691 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:36333282
None Available GCST90013405 Liver enzyme levels (alanine transaminase) 437,267 European ancestry individuals A 0.420817 5E-72 71.302 rs1497406 0.00705001 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:33972514
None Available GCST90027080 Albumin levels 158,000 British ancestry women G 0.58 1E-8 8 rs1497406 0.07 serum albumin measurement (EFO:0004535)
 PMID:34321204
GWAS1039289_H GCST90428729 Alanine aminotransferase levels 1,010,710 European ancestry individuals A NR 7E-82 81.155 rs1497406 0.0074 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:38632349
GWAS1039388_H GCST90018943 Alanine aminotransferase levels 344,136 European ancestry individuals, 150,545 East Asian ancestry individuals G NR 3E-58 57.523 rs1497406 0.0322 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:34594039
GWAS1039584_H GCST90239670 Non-HDL cholesterol levels 1,320,016 European ancestry individuals A 0.414111 1E-14 14 rs1497406 0.0150012 non-high density lipoprotein cholesterol measurement (EFO:0005689)
 PMID:34887591
GWAS1040639_H GCST90018944 Aspartate aminotransferase levels 342,990 European ancestry individuals, 150,068 East Asian ancestry individuals G NR 1E-42 42 rs1497406 0.028 aspartate aminotransferase measurement (EFO:0004736)
 PMID:34594039
None Available GCST90018819 Cholelithiasis 26,122 European ancestry cases, 461,431 European ancestry controls, 9,305 East Asian ancestry cases, 168,253 East Asian ancestry controls G NR 4E-8 7.398 rs1497406 0.0487 cholelithiasis (EFO:0004799)
 PMID:34594039
GWAS1042803_H GCST90018945 Serum albumin levels 315,268 European ancestry individuals, 120,539 East Asian ancestry individuals G NR 7E-25 24.155 rs1497406 0.0227 serum albumin measurement (EFO:0004535)
 PMID:34594039
GWAS1043585_H GCST90239676 Total cholesterol levels 1,320,016 European ancestry individuals G 0.583615 6E-17 16.222 rs1497406 0.0136285 total cholesterol measurement (EFO:0004574)
 PMID:34887591
GWAS1048350_H GCST90239658 Low density lipoprotein cholesterol levels 1,320,016 European ancestry individuals G 0.584114 7E-17 16.155 rs1497406 0.0136287 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34887591
Database Acc Id Source(s)
GWAS Catalog GCST90018734 GWAS Catalog

RGD Curation Notes
Note Type Note Reference