GWAS962894_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS962894_H (testosterone measurement QTL GWAS962894 (human)) Homo sapiens

Symbol: GWAS962894_H
Name: testosterone measurement QTL GWAS962894 (human)
RGD ID: 407313918
Trait: testosterone measurement
Measurement Type: serum testosterone level   (CMO:0000568)    
LOD Score: Not Available
P Value: 5.0E-12
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh382044,411,929 - 44,411,930RGD_MAPPER_PIPELINEGRCh38
GRCh372043,040,569 - 43,040,570RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS962894_HHumanserum testosterone level  IAGPrs6073431405850206Based on the EFO term IDGWAS_CATALOGPMID:34321204

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS962894_HHumantestosterone measurement  IAGPrs6073431405850206 GWAS_CATALOGPMID:34321204
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
69093HNF4Ahepatocyte nuclear factor 4 alpha204435569944434596Human

Position Markers

Peak: (rs6073431)
Human AssemblyChrPosition (strand)Source
GRCh382044,411,929 - 44,411,930RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406993698GWAS642674_Hsex hormone-binding globulin measurement QTL GWAS642674 (human)6e-43sex hormone-binding globulin measurement204441192944411930Human
407021569GWAS670545_Htestosterone measurement QTL GWAS670545 (human)1e-23testosterone measurementserum testosterone level (CMO:0000568)204441192944411930Human
407316996GWAS965972_Hsex hormone-binding globulin measurement QTL GWAS965972 (human)1e-11sex hormone-binding globulin measurement204441192944411930Human
407324129GWAS973105_Hlow density lipoprotein cholesterol measurement QTL GWAS973105 (human)5e-10low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)204441192944411930Human
406994090GWAS643066_Htestosterone measurement QTL GWAS643066 (human)4e-09testosterone measurementserum testosterone level (CMO:0000568)204441192944411930Human
407022408GWAS671384_Hsex hormone-binding globulin measurement QTL GWAS671384 (human)8e-34sex hormone-binding globulin measurement204441192944411930Human
407002064GWAS651040_Hsex hormone-binding globulin measurement QTL GWAS651040 (human)5e-92sex hormone-binding globulin measurement204441192944411930Human
407009424GWAS658400_Htestosterone measurement QTL GWAS658400 (human)5e-24testosterone measurementserum testosterone level (CMO:0000568)204441192944411930Human
406996401GWAS645377_Hsex hormone-binding globulin measurement QTL GWAS645377 (human)2e-32sex hormone-binding globulin measurement204441192944411930Human
1300007BP29_HBlood pressure QTL 29 (human)Blood pressurehypertension susceptibility203653600562536005Human
407026900GWAS675876_Hsex hormone-binding globulin measurement QTL GWAS675876 (human)1e-44sex hormone-binding globulin measurement204441192944411930Human
407250896GWAS899872_Hbody fat percentage QTL GWAS899872 (human)2e-08body fat percentagebody fat percentage (CMO:0000302)204441192944411930Human
407244977GWAS893953_Hsex hormone-binding globulin measurement QTL GWAS893953 (human)4e-19sex hormone-binding globulin measurement204441192944411930Human
407244401GWAS893377_Hsex hormone-binding globulin measurement QTL GWAS893377 (human)0.000003sex hormone-binding globulin measurement204441192944411930Human
407313918GWAS962894_Htestosterone measurement QTL GWAS962894 (human)5e-12testosterone measurementserum testosterone level (CMO:0000568)204441192944411930Human
407196415GWAS845391_Hsex hormone-binding globulin measurement QTL GWAS845391 (human)7e-31sex hormone-binding globulin measurement204441192944411930Human
407326011GWAS974987_Hsex hormone-binding globulin measurement QTL GWAS974987 (human)4e-18sex hormone-binding globulin measurement204441192944411930Human
407029983GWAS678959_Hfree androgen index QTL GWAS678959 (human)9e-11free androgen index204441192944411930Human
407003549GWAS652525_Hsex hormone-binding globulin measurement QTL GWAS652525 (human)2e-73sex hormone-binding globulin measurement204441192944411930Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS642674_H GCST90012106 Sex hormone-binding globulin levels adjusted for BMI 188,908 European ancestry women T 0.5317000000000001 6E-43 42.222 rs6073431 0.0167792 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS643066_H GCST90012102 Bioavailable testosterone levels 188,507 European ancestry women C 0.46831 4E-9 8.398 rs6073431 0.0145654 testosterone measurement (EFO:0004908)
 PMID:32042192
GWAS645377_H GCST90012107 Sex hormone-binding globulin levels 189,473 European ancestry women T 0.5317000000000001 2E-32 31.699 rs6073431 0.0165704 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS651040_H GCST90012110 Sex hormone-binding globulin levels adjusted for BMI 368,929 European ancestry individuals T 0.531115 5E-92 91.302 rs6073431 0.0169942 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS652525_H GCST90012111 Sex hormone-binding globulin levels 370,125 European ancestry individuals T 0.531115 2E-73 72.699 rs6073431 0.0170583 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS658400_H GCST90012113 Total testosterone levels 194,453 European ancestry men T 0.530809 5E-24 23.302 rs6073431 0.0309435 testosterone measurement (EFO:0004908)
 PMID:32042192
GWAS670545_H GCST90239819 Total testosterone levels 176,212 British ancestry men ? NR 1E-23 23 rs6073431 0.0326783 testosterone measurement (EFO:0004908)
 PMID:36653534
GWAS671384_H GCST90239822 Sex hormone-binding globulin levels 188,443 British ancestry women ? NR 8E-34 33.097 rs6073431 0.0376772 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:36653534
GWAS675876_H GCST90239821 Sex hormone-binding globulin levels 163,363 British ancestry men ? NR 1E-44 44 rs6073431 0.0455514 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:36653534
GWAS678959_H GCST90239824 Free androgen index 158,208 British ancestry women ? NR 9E-11 10.046 rs6073431 0.0227567 free androgen index (EFO:0007005)
 PMID:36653534
GWAS845391_H GCST90104297 Sex hormone-binding globulin levels 4,522 African ancestry individuals, 196,901 European ancestry individuals ? NR 7E-31 30.155 rs6073431 11.553 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
GWAS893377_H GCST90104281 Sex hormone-binding globulin levels in premenopausal women 43,477 European ancestry individuals C 0.467962 0.000003 5.523 rs6073431 0.0322475 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
GWAS893953_H GCST90104277 Sex hormone-binding globulin levels in postmenopausal women 92,911 European ancestry individuals C 0.467962 4E-19 18.398 rs6073431 0.0423301 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
GWAS899872_H GCST90432179 Body fat percentage (adjusted for testosterone and SHBG) 157,937 British ancestry males ? NR 2E-8 7.699 rs6073431 0.1 body fat percentage (EFO:0007800)
 PMID:37867527
None Available GCST90104273 Sex hormone-binding globulin levels 196,901 European ancestry individuals C 0.467962 7E-31 30.155 rs6073431 0.0375163 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
GWAS962894_H GCST90027095 Total testosterone levels 148,248 British ancestry men T 0.53 5E-12 11.302 rs6073431 0.12 testosterone measurement (EFO:0004908)
 PMID:34321204
GWAS965972_H GCST90027092 Sex hormone-binding globulin levels 158,000 British ancestry women T 0.53 1E-11 11 rs6073431 0.95 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:34321204
GWAS973105_H GCST90179148 Low-density lipoprotein levels (MTAG) 361,194 European ancestry individuals T NR 5E-10 9.302 rs6073431 0.008655 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:36376304
GWAS974987_H GCST90027091 Sex hormone-binding globulin levels 148,248 British ancestry men T 0.53 4E-18 17.398 rs6073431 0.69 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:34321204
Database Acc Id Source(s)
GWAS Catalog GCST90027095 GWAS Catalog

RGD Curation Notes
Note Type Note Reference