GWAS960953_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS960953_H (total cholesterol measurement QTL GWAS960953 (human)) Homo sapiens

Symbol: GWAS960953_H
Name: total cholesterol measurement QTL GWAS960953 (human)
RGD ID: 407311977
Trait: total cholesterol measurement
Measurement Type: blood total cholesterol level   (CMO:0000051)    
LOD Score: Not Available
P Value: 5.0E-22
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381553,447,229 - 53,447,230RGD_MAPPER_PIPELINEGRCh38
GRCh371553,739,426 - 53,739,427RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS960953_HHumanblood total cholesterol level  IAGPrs79391862405850206Based on the EFO term IDGWAS_CATALOGPMID:34887591

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS960953_HHumantotal cholesterol measurement  IAGPrs79391862405850206 GWAS_CATALOGPMID:34887591
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
38612523LOC105370826uncharacterized LOC105370826155344579553552999Human

Position Markers

Peak: (rs79391862)
Human AssemblyChrPosition (strand)Source
GRCh381553,447,229 - 53,447,230RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407304005GWAS952981_Hlow density lipoprotein cholesterol measurement QTL GWAS952981 (human)9e-11low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)155344722953447230Human
406994696GWAS643672_HC-reactive protein measurement QTL GWAS643672 (human)1e-16C-reactive protein measurementblood C-reactive protein level (CMO:0003160)155344722953447230Human
407314125GWAS963101_Htestosterone measurement QTL GWAS963101 (human)1e-14testosterone measurementserum testosterone level (CMO:0000568)155344722953447230Human
407329227GWAS978203_Hnon-high density lipoprotein cholesterol measurement QTL GWAS978203 (human)3e-17non-high density lipoprotein cholesterol measurementblood non-high density lipoprotein cholesterol level (CMO:0003967)155344722953447230Human
407326857GWAS975833_Hlow density lipoprotein cholesterol measurement QTL GWAS975833 (human)3e-25low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)155344722953447230Human
407325833GWAS974809_Hsex hormone-binding globulin measurement QTL GWAS974809 (human)3e-19sex hormone-binding globulin measurement155344722953447230Human
407209557GWAS858533_Htestosterone measurement QTL GWAS858533 (human)2e-14testosterone measurementserum testosterone level (CMO:0000568)155344722953447230Human
407246036GWAS895012_Hbody fat percentage QTL GWAS895012 (human)1e-11body fat percentagebody fat percentage (CMO:0000302)155344722953447230Human
407297620GWAS946596_Htestosterone measurement QTL GWAS946596 (human)6e-38testosterone measurementserum testosterone level (CMO:0000568)155344722953447230Human
2299958PRSTS330_HProstate tumor susceptibility QTL 330 (human)1.020.0151Prostate tumor susceptibility153479023060790230Human
407219551GWAS868527_Hsex hormone-binding globulin measurement QTL GWAS868527 (human)2e-46sex hormone-binding globulin measurement155344722953447230Human
407166425GWAS815401_Hsex hormone-binding globulin measurement QTL GWAS815401 (human)9e-34sex hormone-binding globulin measurement155344722953447230Human
407241894GWAS890870_Hsex hormone-binding globulin measurement QTL GWAS890870 (human)8e-20sex hormone-binding globulin measurement155344722953447230Human
407315559GWAS964535_Hnon-high density lipoprotein cholesterol measurement QTL GWAS964535 (human)2e-18non-high density lipoprotein cholesterol measurementblood non-high density lipoprotein cholesterol level (CMO:0003967)155344722953447230Human
407311589GWAS960565_Hlow density lipoprotein cholesterol measurement QTL GWAS960565 (human)1e-28low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)155344722953447230Human
407151847GWAS800823_Hsex hormone-binding globulin measurement QTL GWAS800823 (human)2e-13sex hormone-binding globulin measurement155344722953447230Human
407346274GWAS995250_Htotal cholesterol measurement QTL GWAS995250 (human)2e-25total cholesterol measurementblood total cholesterol level (CMO:0000051)155344722953447230Human
407244396GWAS893372_Hsex hormone-binding globulin measurement QTL GWAS893372 (human)0.0000003sex hormone-binding globulin measurement155344722953447230Human
407039145GWAS688121_Hantihyperlipidemic drug use measurement QTL GWAS688121 (human)9e-13antihyperlipidemic drug use measurement155344722953447230Human
1559354LDLPS4_HLow density lipoprotein particle size QTL 4 (human)2.20.019LDL particle size153479023060790230Human
407169706GWAS818682_Htestosterone measurement QTL GWAS818682 (human)3e-12sex hormone-binding globulin measurementserum testosterone level (CMO:0000568)155344722953447230Human
407311977GWAS960953_Htotal cholesterol measurement QTL GWAS960953 (human)5e-22total cholesterol measurementblood total cholesterol level (CMO:0000051)155344722953447230Human
407246070GWAS895046_Hbody fat percentage QTL GWAS895046 (human)2e-08body fat percentagebody fat percentage (CMO:0000302)155344722953447230Human
407221236GWAS870212_Hsex hormone-binding globulin measurement QTL GWAS870212 (human)9e-35sex hormone-binding globulin measurement155344722953447230Human
407021300GWAS670276_Htestosterone measurement QTL GWAS670276 (human)2e-34testosterone measurementserum testosterone level (CMO:0000568)155344722953447230Human
407302719GWAS951695_Hsex hormone-binding globulin measurement QTL GWAS951695 (human)2e-121sex hormone-binding globulin measurement155344722953447230Human
407302525GWAS951501_Hsex hormone-binding globulin measurement QTL GWAS951501 (human)4e-99sex hormone-binding globulin measurement155344722953447230Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS643672_H GCST011350 C-reactive protein levels 76,081 European ancestry individuals, 127,395 Japanese ancestry individuals ? NR 1E-16 16 rs79391862 0.1672 C-reactive protein measurement (EFO:0004458)
 PMID:33339817
GWAS670276_H GCST90239819 Total testosterone levels 176,212 British ancestry men ? NR 2E-34 33.699 rs79391862 0.17003 testosterone measurement (EFO:0004908)
 PMID:36653534
GWAS688121_H GCST90250902 Medication use for hyperlipidemia (number of purchases) 567,671 European ancestry individuals ? NR 9E-13 12.046 rs79391862 0.029728 antihyperlipidemic drug use measurement (EFO:0803367)
 PMID:36653479
GWAS800823_H GCST90027092 Sex hormone-binding globulin levels 158,000 British ancestry women C 0.01 2E-13 12.699 rs79391862 4.38 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:34321204
GWAS815401_H GCST90104297 Sex hormone-binding globulin levels 4,522 African ancestry individuals, 196,901 European ancestry individuals ? NR 9E-34 33.046 rs79391862 12.118 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
GWAS818682_H GCST90026655 Low testosterone levels 13,409 European ancestry male cases, 98,267 European ancestry male controls C 0.01 3E-12 11.523 rs79391862 1.38 testosterone measurement (EFO:0004908)
 PMID:34337532
GWAS858533_H GCST90012114 Total testosterone levels 425,097 European ancestry individuals A 0.986046 2E-14 13.699 rs79391862 0.0407221 testosterone measurement (EFO:0004908)
 PMID:32042192
GWAS868527_H GCST90012106 Sex hormone-binding globulin levels adjusted for BMI 188,908 European ancestry women A 0.985902 2E-46 45.699 rs79391862 0.0730502 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS870212_H GCST90012107 Sex hormone-binding globulin levels 189,473 European ancestry women A 0.985902 9E-35 34.046 rs79391862 0.0737538 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS890870_H GCST90104277 Sex hormone-binding globulin levels in postmenopausal women 92,911 European ancestry individuals C 0.013288 8E-20 19.097 rs79391862 0.180956 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
GWAS893372_H GCST90104281 Sex hormone-binding globulin levels in premenopausal women 43,477 European ancestry individuals C 0.013288 3E-7 6.523 rs79391862 0.155013 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
GWAS895012_H GCST90432180 Body fat percentage (adjusted for testosterone and SHBG) 154,337 British ancestry females ? NR 1E-11 11 rs79391862 0.6 body fat percentage (EFO:0007800)
 PMID:37867527
GWAS895046_H GCST90432179 Body fat percentage (adjusted for testosterone and SHBG) 157,937 British ancestry males ? NR 2E-8 7.699 rs79391862 0.45 body fat percentage (EFO:0007800)
 PMID:37867527
None Available GCST90104273 Sex hormone-binding globulin levels 196,901 European ancestry individuals C 0.013288 9E-34 33.046 rs79391862 0.167336 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
GWAS946596_H GCST90012113 Total testosterone levels 194,453 European ancestry men A 0.986175 6E-38 37.222 rs79391862 0.157273 testosterone measurement (EFO:0004908)
 PMID:32042192
GWAS951501_H GCST90012111 Sex hormone-binding globulin levels 370,125 European ancestry individuals A 0.98604 4E-99 98.398 rs79391862 0.083002 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS951695_H GCST90012110 Sex hormone-binding globulin levels adjusted for BMI 368,929 European ancestry individuals A 0.98604 2E-121 120.699 rs79391862 0.0824289 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS952981_H GCST90002412 Low density lipoprotein cholesterol levels 431,167 European ancestry individuals A 0.986175 9E-11 10.046 rs79391862 0.0542363 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:32493714
GWAS960565_H GCST90239655 Low density lipoprotein cholesterol levels 40,963 South Asian ancestry individuals, 48,057 Hispanic individuals, 99,432 Admixed African or African ancestry individuals, 146,492 East Asian ancestry individuals, 1,320,016 European ancestry individuals ? NR 1E-28 28 rs79391862 N/A low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34887591
GWAS960953_H GCST90239676 Total cholesterol levels 1,320,016 European ancestry individuals C 0.0205508 5E-22 21.302 rs79391862 0.0593847 total cholesterol measurement (EFO:0004574)
 PMID:34887591
None Available GCST90027093 Sex hormone-binding globulin levels 104,632 British ancestry post-menopausal women C 0.01 3E-12 11.523 rs79391862 4.83 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:34321204
GWAS963101_H GCST90027095 Total testosterone levels 148,248 British ancestry men C 0.01 1E-14 14 rs79391862 0.58 testosterone measurement (EFO:0004908)
 PMID:34321204
GWAS964535_H GCST90239667 Non-HDL cholesterol levels 40,963 South Asian ancestry individuals, 48,057 Hispanic individuals, 99,432 Admixed African or African ancestry individuals, 146,492 East Asian ancestry individuals, 1,320,016 European ancestry individuals ? NR 2E-18 17.699 rs79391862 N/A non-high density lipoprotein cholesterol measurement (EFO:0005689)
 PMID:34887591
GWAS974809_H GCST90027091 Sex hormone-binding globulin levels 148,248 British ancestry men C 0.01 3E-19 18.523 rs79391862 3.1 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:34321204
GWAS975833_H GCST90239658 Low density lipoprotein cholesterol levels 1,320,016 European ancestry individuals C 0.0201963 3E-25 24.523 rs79391862 0.0639367 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34887591
GWAS978203_H GCST90239670 Non-HDL cholesterol levels 1,320,016 European ancestry individuals C 0.023114 3E-17 16.523 rs79391862 0.0582112 non-high density lipoprotein cholesterol measurement (EFO:0005689)
 PMID:34887591
GWAS995250_H GCST90239673 Total cholesterol levels 40,963 South Asian ancestry individuals, 48,057 Hispanic individuals, 99,432 Admixed African or African ancestry individuals, 146,492 East Asian ancestry individuals, 1,320,016 European ancestry individuals ? NR 2E-25 24.699 rs79391862 N/A total cholesterol measurement (EFO:0004574)
 PMID:34887591
Database Acc Id Source(s)
GWAS Catalog GCST90239676 GWAS Catalog

RGD Curation Notes
Note Type Note Reference