QTL |
GWAS Catalog Study |
Disease Trait |
Study Size |
Risk Allele |
Risk Allele Frequency |
P Value |
P Value MLOG |
Peak Marker |
Reported Odds Ratio or Beta-coefficient |
Ontology Accession |
PubMed |
GWAS642186_H |
GCST011346 |
Total cholesterol levels |
76,081 European ancestry individuals, 127,395 Japanese ancestry individuals |
? |
NR |
7E-24 |
23.155 |
rs553427 |
0.0377 |
total cholesterol measurement (EFO:0004574)
|
PMID:33339817 |
GWAS684839_H |
GCST90269646 |
Free cholesterol in small LDL (UKB data field 23549) |
88,329 European ancestry individuals |
C |
0.483055 |
3E-11 |
10.523 |
rs553427 |
0.031555 |
free cholesterol in small LDL measurement (EFO:0022271)
|
PMID:36764567 |
GWAS685636_H |
GCST90269643 |
Phospholipids in small LDL (UKB data field 23546) |
88,329 European ancestry individuals |
C |
0.483055 |
6E-12 |
11.222 |
rs553427 |
0.0326662 |
phospholipids in small LDL measurement (EFO:0022297)
|
PMID:36764567 |
GWAS764658_H |
GCST90269625 |
Free cholesterol in IDL (UKB data field 23528) |
88,329 European ancestry individuals |
C |
0.483055 |
6E-10 |
9.222 |
rs553427 |
0.0284959 |
free cholesterol in IDL measurement (EFO:0022181)
|
PMID:36764567 |
GWAS793588_H |
GCST006004 |
Low density lipoprotein cholesterol levels |
72,866 Japanese ancestry individuals |
? |
NR |
1E-9 |
9 |
rs553427 |
0.03482 |
low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:29403010 |
GWAS834651_H |
GCST90092863 |
Concentration of large LDL particles |
115,082 European ancestry individuals |
C |
0.482963 |
4E-15 |
14.398 |
rs553427 |
0.0323065 |
low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
None Available |
GCST90092885 |
Free cholesterol levels in LDL |
115,082 European ancestry individuals |
C |
0.482963 |
4E-15 |
14.398 |
rs553427 |
0.0321631 |
free cholesterol measurement (EFO:0008591) low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS836331_H |
GCST90092858 |
Cholesteryl ester levels in large LDL |
115,082 European ancestry individuals |
C |
0.482963 |
3E-16 |
15.523 |
rs553427 |
0.0333905 |
cholesteryl ester measurement (EFO:0010351) low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS837700_H |
GCST90092862 |
Total lipid levels in large LDL |
115,082 European ancestry individuals |
C |
0.482963 |
9E-16 |
15.046 |
rs553427 |
0.032868 |
low density lipoprotein cholesterol measurement (EFO:0004611) lipid measurement (EFO:0004529)
|
PMID:35213538 |
GWAS838987_H |
GCST90092884 |
Cholesteryl ester levels in LDL |
115,082 European ancestry individuals |
C |
0.482963 |
1E-15 |
15 |
rs553427 |
0.0328809 |
cholesteryl ester measurement (EFO:0010351) low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS839535_H |
GCST90018741 |
LDL cholesterol |
72,866 East Asian ancestry individuals |
T |
0.710205 |
1E-10 |
10 |
rs553427 |
0.0338519 |
low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:34594039 |
GWAS841293_H |
GCST90092864 |
Phospholipid levels in large LDL |
115,082 European ancestry individuals |
C |
0.482963 |
6E-14 |
13.222 |
rs553427 |
0.0307558 |
low density lipoprotein cholesterol measurement (EFO:0004611) phospholipid measurement (EFO:0004639)
|
PMID:35213538 |
GWAS843361_H |
GCST90092856 |
Cholesterol levels in large LDL |
115,082 European ancestry individuals |
C |
0.482963 |
4E-16 |
15.398 |
rs553427 |
0.0332394 |
total cholesterol measurement (EFO:0004574) low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS843622_H |
GCST90092860 |
Free cholesterol levels in large LDL |
115,082 European ancestry individuals |
C |
0.482963 |
3E-15 |
14.523 |
rs553427 |
0.0319903 |
free cholesterol measurement (EFO:0008591) low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS864040_H |
GCST90092888 |
Phospholipid levels in LDL |
115,082 European ancestry individuals |
C |
0.482963 |
2E-14 |
13.699 |
rs553427 |
0.0315166 |
low density lipoprotein cholesterol measurement (EFO:0004611) phospholipid measurement (EFO:0004639)
|
PMID:35213538 |
GWAS864300_H |
GCST90092886 |
Total lipid levels in LDL |
115,082 European ancestry individuals |
C |
0.482963 |
2E-15 |
14.699 |
rs553427 |
0.0327483 |
low density lipoprotein cholesterol measurement (EFO:0004611) lipid measurement (EFO:0004529)
|
PMID:35213538 |
GWAS864313_H |
GCST90092887 |
Concentration of LDL particles |
115,082 European ancestry individuals |
C |
0.482963 |
5E-15 |
14.302 |
rs553427 |
0.0322742 |
low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS891708_H |
GCST90092837 |
Total lipid levels in IDL |
115,082 European ancestry individuals |
C |
0.482963 |
3E-12 |
11.523 |
rs553427 |
0.0278789 |
lipid measurement (EFO:0004529) intermediate density lipoprotein measurement (EFO:0008595)
|
PMID:35213538 |
None Available |
GCST90092930 |
Total cholesterol minus HDL-C levels |
115,082 European ancestry individuals |
C |
0.482963 |
2E-14 |
13.699 |
rs553427 |
0.0313813 |
total cholesterol measurement (EFO:0004574)
|
PMID:35213538 |
None Available |
GCST90092910 |
Total lipid levels in medium LDL |
115,082 European ancestry individuals |
C |
0.482963 |
6E-14 |
13.222 |
rs553427 |
0.0310149 |
low density lipoprotein cholesterol measurement (EFO:0004611) lipid measurement (EFO:0004529)
|
PMID:35213538 |
GWAS904025_H |
GCST90092908 |
Free cholesterol levels in medium LDL |
115,082 European ancestry individuals |
C |
0.482963 |
1E-14 |
14 |
rs553427 |
0.0318296 |
free cholesterol measurement (EFO:0008591) low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS905973_H |
GCST90239652 |
High density lipoprotein cholesterol levels |
1,320,016 European ancestry individuals |
T |
0.527256 |
6E-21 |
20.222 |
rs553427 |
0.0171565 |
high density lipoprotein cholesterol measurement (EFO:0004612)
|
PMID:34887591 |
GWAS906317_H |
GCST90092912 |
Phospholipid levels in medium LDL |
115,082 European ancestry individuals |
C |
0.482963 |
1E-13 |
13 |
rs553427 |
0.0306847 |
low density lipoprotein cholesterol measurement (EFO:0004611) phospholipid measurement (EFO:0004639)
|
PMID:35213538 |
None Available |
GCST90092904 |
Cholesterol levels in medium LDL |
115,082 European ancestry individuals |
C |
0.482963 |
6E-14 |
13.222 |
rs553427 |
0.0310354 |
total cholesterol measurement (EFO:0004574) low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS909788_H |
GCST90092906 |
Cholesteryl ester levels in medium LDL |
115,082 European ancestry individuals |
C |
0.482963 |
4E-13 |
12.398 |
rs553427 |
0.0299671 |
cholesteryl ester measurement (EFO:0010351) low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS918539_H |
GCST90092831 |
Cholesterol levels in IDL |
115,082 European ancestry individuals |
C |
0.482963 |
2E-11 |
10.699 |
rs553427 |
0.0268913 |
total cholesterol measurement (EFO:0004574) intermediate density lipoprotein measurement (EFO:0008595)
|
PMID:35213538 |
GWAS918881_H |
GCST90092833 |
Cholesteryl ester levels in IDL |
115,082 European ancestry individuals |
C |
0.482963 |
6E-11 |
10.222 |
rs553427 |
0.0260863 |
cholesteryl ester measurement (EFO:0010351) intermediate density lipoprotein measurement (EFO:0008595)
|
PMID:35213538 |
GWAS933368_H |
GCST90018942 |
Serum alkaline phosphatase levels |
344,292 European ancestry individuals, 118,886 East Asian ancestry individuals |
T |
NR |
3E-14 |
13.523 |
rs553427 |
0.0155 |
alkaline phosphatase measurement (EFO:0004533)
|
PMID:34594039 |
GWAS936926_H |
GCST90092916 |
Cholesterol levels in medium VLDL |
115,082 European ancestry individuals |
C |
0.482963 |
2E-13 |
12.699 |
rs553427 |
0.0301972 |
total cholesterol measurement (EFO:0004574) very low density lipoprotein cholesterol measurement (EFO:0008317)
|
PMID:35213538 |
GWAS943514_H |
GCST90092920 |
Free cholesterol levels in medium VLDL |
115,082 European ancestry individuals |
C |
0.482963 |
8E-13 |
12.097 |
rs553427 |
0.0295578 |
free cholesterol measurement (EFO:0008591) very low density lipoprotein cholesterol measurement (EFO:0008317)
|
PMID:35213538 |
GWAS947133_H |
GCST90239649 |
High density lipoprotein cholesterol levels |
40,963 South Asian ancestry individuals, 48,057 Hispanic individuals, 99,432 Admixed African or African ancestry individuals, 146,492 East Asian ancestry individuals, 1,320,016 European ancestry individuals |
? |
NR |
2E-29 |
28.699 |
rs553427 |
N/A |
high density lipoprotein cholesterol measurement (EFO:0004612)
|
PMID:34887591 |
None Available |
GCST90092883 |
LDL cholesterol levels |
115,082 European ancestry individuals |
C |
0.482963 |
1E-15 |
15 |
rs553427 |
0.0330153 |
low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS958327_H |
GCST90092985 |
Total cholesterol levels |
115,082 European ancestry individuals |
C |
0.482963 |
6E-15 |
14.222 |
rs553427 |
0.0311849 |
total cholesterol measurement (EFO:0004574)
|
PMID:35213538 |
None Available |
GCST90092809 |
Apolipoprotein B levels |
115,082 European ancestry individuals |
C |
0.482963 |
6E-14 |
13.222 |
rs553427 |
0.0309179 |
apolipoprotein B measurement (EFO:0004615)
|
PMID:35213538 |
None Available |
GCST90092814 |
Clinical LDL cholesterol levels |
115,082 European ancestry individuals |
C |
0.482963 |
3E-14 |
13.523 |
rs553427 |
0.031181 |
low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
None Available |
GCST90092988 |
Total free cholesterol levels |
115,082 European ancestry individuals |
C |
0.482963 |
4E-15 |
14.398 |
rs553427 |
0.0316618 |
free cholesterol measurement (EFO:0008591)
|
PMID:35213538 |
None Available |
GCST90092986 |
Total esterified cholesterol levels |
115,082 European ancestry individuals |
C |
0.482963 |
1E-14 |
14 |
rs553427 |
0.0307547 |
esterified cholesterol measurement (EFO:0008589)
|
PMID:35213538 |
GWAS963550_H |
GCST90092972 |
Free cholesterol levels in small VLDL |
115,082 European ancestry individuals |
C |
0.482963 |
5E-13 |
12.302 |
rs553427 |
0.02984 |
free cholesterol measurement (EFO:0008591) very low density lipoprotein cholesterol measurement (EFO:0008317)
|
PMID:35213538 |
GWAS964494_H |
GCST90092962 |
Total lipid levels in small LDL |
115,082 European ancestry individuals |
C |
0.482963 |
7E-15 |
14.155 |
rs553427 |
0.0321215 |
low density lipoprotein cholesterol measurement (EFO:0004611) lipid measurement (EFO:0004529)
|
PMID:35213538 |
GWAS965035_H |
GCST90092958 |
Cholesteryl ester levels in small LDL |
115,082 European ancestry individuals |
C |
0.482963 |
7E-14 |
13.155 |
rs553427 |
0.0309689 |
cholesteryl ester measurement (EFO:0010351) low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
None Available |
GCST90092956 |
Cholesterol levels in small LDL |
115,082 European ancestry individuals |
C |
0.482963 |
1E-14 |
14 |
rs553427 |
0.0318115 |
total cholesterol measurement (EFO:0004574) low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS968791_H |
GCST90239658 |
Low density lipoprotein cholesterol levels |
1,320,016 European ancestry individuals |
T |
0.526973 |
3E-135 |
134.523 |
rs553427 |
0.0403134 |
low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:34887591 |
None Available |
GCST90092949 |
Free cholesterol to total lipids ratio in small HDL |
115,082 European ancestry individuals |
C |
0.482963 |
2E-15 |
14.699 |
rs553427 |
0.0310851 |
free cholesterol:total lipids ratio (EFO:0020945) high density lipoprotein cholesterol measurement (EFO:0004612)
|
PMID:35213538 |
None Available |
GCST90092943 |
Remnant cholesterol (non-HDL, non-LDL -cholesterol) |
115,082 European ancestry individuals |
C |
0.482963 |
3E-12 |
11.523 |
rs553427 |
0.0286973 |
remnant cholesterol measurement (EFO:0010815)
|
PMID:35213538 |
None Available |
GCST90092964 |
Phospholipid levels in small LDL |
115,082 European ancestry individuals |
C |
0.482963 |
2E-15 |
14.699 |
rs553427 |
0.032725 |
low density lipoprotein cholesterol measurement (EFO:0004611) phospholipid measurement (EFO:0004639)
|
PMID:35213538 |
GWAS976003_H |
GCST90092989 |
Total lipid levels in lipoprotein particles |
115,082 European ancestry individuals |
C |
0.482963 |
2E-12 |
11.699 |
rs553427 |
0.0285619 |
lipid measurement (EFO:0004529) lipoprotein measurement (EFO:0004732)
|
PMID:35213538 |
GWAS977368_H |
GCST90092960 |
Free cholesterol levels in small LDL |
115,082 European ancestry individuals |
C |
0.482963 |
5E-14 |
13.302 |
rs553427 |
0.0310183 |
free cholesterol measurement (EFO:0008591) low density lipoprotein cholesterol measurement (EFO:0004611)
|
PMID:35213538 |
GWAS978688_H |
GCST90092991 |
Total phospholipid levels in lipoprotein particles |
115,082 European ancestry individuals |
C |
0.482963 |
9E-10 |
9.046 |
rs553427 |
0.0240608 |
lipoprotein measurement (EFO:0004732) phospholipid measurement (EFO:0004639)
|
PMID:35213538 |