GWAS874623_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS874623_H (phospholipids in LDL measurement QTL GWAS874623 (human)) Homo sapiens

Symbol: GWAS874623_H
Name: phospholipids in LDL measurement QTL GWAS874623 (human)
RGD ID: 407225647
Trait: phospholipids in LDL measurement
Measurement Type: blood intermediate density lipoprotein cholesterol level   (CMO:0001562)    
blood lipid measurement   (CMO:0000050)    
blood low density lipoprotein cholesterol level   (CMO:0000053)    
LOD Score: Not Available
P Value: 2.0E-14
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3889,329,732 - 9,329,733RGD_MAPPER_PIPELINEGRCh38
GRCh3789,187,242 - 9,187,243RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS874623_HHumanblood intermediate density lipoprotein cholesterol level  IAGPrs1461729405850206Based on the EFO term IDGWAS_CATALOGPMID:35213538
GWAS874623_HHumanblood lipid measurement  IAGPrs1461729405850206Based on the EFO term IDGWAS_CATALOGPMID:35213538
GWAS874623_HHumanblood low density lipoprotein cholesterol level  IAGPrs1461729405850206Based on the EFO term IDGWAS_CATALOGPMID:38448586

Experimental Factor Annotations    Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
16558181PPP1R3B-DTPPP1R3B divergent transcript893250519335080Human

Position Markers

Peak: (rs1461729)
Human AssemblyChrPosition (strand)Source
GRCh3889,329,732 - 9,329,733RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407222213GWAS871189_Hesterified cholesterol measurement QTL GWAS871189 (human)2e-26esterified cholesterol measurement893297329329733Human
407171525GWAS820501_Htotal cholesterol measurement QTL GWAS820501 (human)0.0000002total cholesterol measurementblood total cholesterol level (CMO:0000051)893297329329733Human
407237568GWAS886544_Hpolyunsaturated fatty acid measurement QTL GWAS886544 (human)8e-21milk polyunsaturated fatty acid amount (VT:0010374)milk polyunsaturated fatty acid measurement (CMO:0000821)893297329329733Human
407353793GWAS1002769_Hlow density lipoprotein cholesterol measurement, lipid measurement QTL GWAS1002769 (human)6e-19low density lipoprotein cholesterol measurement, lipid measurementblood lipid measurement (CMO:0000050)893297329329733Human
407217730GWAS866706_Hcholesterol in IDL measurement QTL GWAS866706 (human)1e-17cholesterol in IDL measurement blood cholesterol level (CMO:0002280)893297329329733Human
407254977GWAS903953_Htotal lipids in large LDL QTL GWAS903953 (human)9e-17total cholesterol measurement, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407356617GWAS1005593_Hsphingomyelin measurement QTL GWAS1005593 (human)1e-23sphingomyelin measurement893297329329733Human
407360215GWAS1009191_Htotal cholesterol in medium LDL QTL GWAS1009191 (human)3e-15total cholesterol in medium LDL893297329329733Human
407352144GWAS1001120_Htotal cholesterol measurement, low density lipoprotein cholesterol measurement QTL GWAS1001120 (human)2e-20cholesterol:total lipids ratio, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407143388GWAS792364_Hhigh density lipoprotein cholesterol measurement QTL GWAS792364 (human)7e-09high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)893297329329733Human
407354334GWAS1003310_Hfree cholesterol measurement, intermediate density lipoprotein measurement QTL GWAS1003310 (human)9e-14free cholesterol measurement, intermediate density lipoprotein measurementblood intermediate density lipoprotein cholesterol level (CMO:0001562)893297329329733Human
407181272GWAS830248_Hlinoleic acid measurement QTL GWAS830248 (human)2e-25linoleic acid measurementblood free fatty acids level (CMO:0000117)893297329329733Human
407379304GWAS1028280_Hhigh density lipoprotein cholesterol measurement QTL GWAS1028280 (human)4e-09high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)893297329329733Human
1298482BP2_HBlood pressure QTL 2 (human)1.8Blood pressurediastolic8695325632953256Human
407237860GWAS886836_Homega-6 polyunsaturated fatty acid measurement QTL GWAS886836 (human)9e-20omega-6 polyunsaturated fatty acid measurement893297329329733Human
407379306GWAS1028282_Hlow density lipoprotein cholesterol measurement QTL GWAS1028282 (human)0.000003low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407351524GWAS1000500_Htotal cholesterol measurement, intermediate density lipoprotein measurement QTL GWAS1000500 (human)2e-17total cholesterol in small LDLblood intermediate density lipoprotein cholesterol level (CMO:0001562)893297329329733Human
407200739GWAS849715_Hlow density lipoprotein cholesterol measurement QTL GWAS849715 (human)3e-16low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407352544GWAS1001520_Hfree cholesterol measurement, low density lipoprotein cholesterol measurement QTL GWAS1001520 (human)5e-18free cholesterol measurement, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407255649GWAS904625_Htotal lipids in LDL measurement QTL GWAS904625 (human)1e-14total lipids in LDL measurement 893297329329733Human
407359598GWAS1008574_Hlow density lipoprotein cholesterol measurement QTL GWAS1008574 (human)1e-13low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407238124GWAS887100_Htotal lipids in medium LDL QTL GWAS887100 (human)2e-11hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH)) measurementblood total cholesterol level (CMO:0000051)893297329329733Human
407344493GWAS993469_Hserum alanine aminotransferase measurement QTL GWAS993469 (human)2e-09serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)893297329329733Human
407254124GWAS903100_Hcholesteryl ester measurement QTL GWAS903100 (human)9e-18blood lipid amount (VT:0003949)893297329329733Human
407351020GWAS999996_Htriglyceride:HDL cholesterol ratio QTL GWAS999996 (human)1e-11triglyceride:HDL cholesterol ratio893297329329733Human
407217138GWAS866114_Hfree cholesterol in IDL measurement QTL GWAS866114 (human)4e-15blood lipid amount (VT:0003949)blood intermediate density lipoprotein cholesterol level (CMO:0001562)893297329329733Human
407250303GWAS899279_Htotal lipids in IDL QTL GWAS899279 (human)5e-14total lipids in IDL893297329329733Human
407202684GWAS851660_Hlow density lipoprotein cholesterol measurement QTL GWAS851660 (human)6e-16low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407356925GWAS1005901_Hpolyunsaturated fatty acid measurement QTL GWAS1005901 (human)7e-20milk polyunsaturated fatty acid amount (VT:0010374)milk polyunsaturated fatty acid measurement (CMO:0000821)893297329329733Human
407355385GWAS1004361_Htriglyceride:HDL cholesterol ratio QTL GWAS1004361 (human)7e-08triglyceride:HDL cholesterol ratio893297329329733Human
407219589GWAS868565_Hfree cholesterol in medium LDL measurement QTL GWAS868565 (human)2e-16low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407220101GWAS869077_Hphospholipids in IDL measurement QTL GWAS869077 (human)5e-10phospholipids in IDL measurementblood intermediate density lipoprotein phospholipid level (CMO:0001574)893297329329733Human
407255813GWAS904789_Hfree cholesterol in small LDL measurement QTL GWAS904789 (human)3e-132-hydroxypalmitate measurement893297329329733Human
407350657GWAS999633_Htotal cholesterol measurement QTL GWAS999633 (human)2e-29total cholesterol measurementblood total cholesterol level (CMO:0000051)893297329329733Human
407168140GWAS817116_Hhigh density lipoprotein cholesterol measurement QTL GWAS817116 (human)4e-17free cholesterol measurement, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407204365GWAS853341_Htotal cholesterol measurement QTL GWAS853341 (human)3e-12level of inactive C-alpha-formylglycine-generating enzyme 2 in blood serumblood total cholesterol level (CMO:0000051)893297329329733Human
407351820GWAS1000796_Hcholesteryl ester measurement, intermediate density lipoprotein measurement QTL GWAS1000796 (human)1e-18blood lipid amount (VT:0003949)blood intermediate density lipoprotein cholesterol level (CMO:0001562)893297329329733Human
407376646GWAS1025622_Hserum alanine aminotransferase measurement QTL GWAS1025622 (human)2e-44serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)893297329329733Human
407357192GWAS1006168_Hcholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS1006168 (human)3e-11high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)893297329329733Human
407389720GWAS1038696_Hserum alanine aminotransferase measurement QTL GWAS1038696 (human)6e-51serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)893297329329733Human
407350677GWAS999653_Hlow density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio QTL GWAS999653 (human)3e-21low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratioblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407355796GWAS1004772_Htotal lipids in small LDL QTL GWAS1004772 (human)7e-17total lipids in small LDLblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407179024GWAS828000_Htriglyceride measurement QTL GWAS828000 (human)9e-09triglyceride measurementblood triglyceride level (CMO:0000118)893297329329733Human
407093014GWAS741990_Herythrocyte count QTL GWAS741990 (human)2e-10blood lipid amount (VT:0003949)red blood cell count (CMO:0000025)893297329329733Human
407354001GWAS1002977_Hfree cholesterol measurement QTL GWAS1002977 (human)5e-23free cholesterol measurementblood cholesterol level (CMO:0002280)893297329329733Human
407221011GWAS869987_Hphospholipids in medium LDL measurement QTL GWAS869987 (human)4e-12phospholipids in medium LDL measurementblood low density lipoprotein phospholipid level (CMO:0001568)893297329329733Human
407350942GWAS999918_Hesterified cholesterol measurement QTL GWAS999918 (human)7e-32esterified cholesterol measurement893297329329733Human
407207836GWAS856812_Hfree cholesterol in LDL measurement QTL GWAS856812 (human)2e-18blood lipid amount (VT:0003949)893297329329733Human
407353500GWAS1002476_Haspartate aminotransferase measurement QTL GWAS1002476 (human)7e-13aspartate aminotransferase measurementblood aspartate aminotransferase activity level (CMO:0000580)893297329329733Human
407350683GWAS999659_Hcholesteryl ester measurement, low density lipoprotein cholesterol measurement QTL GWAS999659 (human)1e-20blood lipid amount (VT:0003949)blood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407359899GWAS1008875_Hphospholipids in medium LDL measurement QTL GWAS1008875 (human)6e-17phospholipids in medium LDL measurementblood low density lipoprotein phospholipid level (CMO:0001568)893297329329733Human
407350939GWAS999915_Hserum alanine aminotransferase measurement QTL GWAS999915 (human)8e-29serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)893297329329733Human
407248166GWAS897142_Hlinoleic acid measurement QTL GWAS897142 (human)2e-13linoleic acid measurementblood free fatty acids level (CMO:0000117)893297329329733Human
407357990GWAS1006966_Hphosphoglycerides measurement QTL GWAS1006966 (human)7e-16phosphoglycerides measurement 893297329329733Human
407357733GWAS1006709_Hcholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS1006709 (human)9e-11cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)893297329329733Human
407211299GWAS860275_Htotal lipids in lipoprotein particles measurement QTL GWAS860275 (human)8e-18total lipids in lipoprotein particles measurement 893297329329733Human
407225647GWAS874623_Hphospholipids in LDL measurement QTL GWAS874623 (human)2e-14low density lipoprotein cholesterol measurement, lipid measurementblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407363884GWAS1012860_Hlow density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio QTL GWAS1012860 (human)3e-20low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratioblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407356588GWAS1005564_Hesterified cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS1005564 (human)2e-19esterified cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)893297329329733Human
407359404GWAS1008380_Hphospholipids in small LDL measurement QTL GWAS1008380 (human)9e-22phospholipids in small LDL measurement 893297329329733Human
407203502GWAS852478_Htotal cholesterol measurement QTL GWAS852478 (human)5e-24total cholesterol measurementblood total cholesterol level (CMO:0000051)893297329329733Human
407351851GWAS1000827_Hlow density lipoprotein cholesterol measurement, phospholipid measurement QTL GWAS1000827 (human)4e-18low density lipoprotein cholesterol measurement, phospholipid measurementblood low density lipoprotein cholesterol level (CMO:0000053)893297329329733Human
407349161GWAS998137_Hlow density lipoprotein cholesterol measurement QTL GWAS998137 (human)4e-19low density lipoprotein cholesterol measurementblood cholesterol level (CMO:0002280)893297329329733Human
407239217GWAS888193_Hfree cholesterol in large LDL measurement QTL GWAS888193 (human)1e-19free cholesterol in large LDL measurement893297329329733Human
407249597GWAS898573_Hcholesterol in small LDL measurement QTL GWAS898573 (human)6e-11cholesterol in small LDL measurement 893297329329733Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS741990_H GCST007069 Red blood cell count approximately 445,000 European ancestry individuals ? NR 2E-10 9.699 rs1461729 N/A erythrocyte count (EFO:0004305)
 PMID:30595370
GWAS792364_H GCST002043 HDL cholesterol 7,917 African American individuals, 3,506 Hispanic individuals T 0.116 7E-9 8.155 rs1461729 0.0355 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:23726366
GWAS817116_H GCST008035 High density lipoprotein cholesterol levels 10,085 African American individuals, 17,751 Hispanic/Latino individuals, 2,378 Asian ancestry individuals, 1,912 Native Hawaiian ancestry individuals, 604 Native American ancestry individuals, 333 individuals ? NR 4E-17 16.398 rs1461729 1.280136 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:31217584
GWAS820501_H GCST008045 Total cholesterol levels 10,137 African American individuals, 17,802 Hispanic/Latino individuals, 2,387 Asian ancestry individuals, 1,915 Native Hawaiian ancestry individuals, 604 Native American ancestry individuals, 340 individuals ? NR 2E-7 6.699 rs1461729 2.522105 total cholesterol measurement (EFO:0004574)
 PMID:31217584
GWAS828000_H GCST90239662 Triglyceride levels 99,432 Admixed African or African ancestry individuals G 0.88085 9E-9 8.046 rs1461729 0.0420411 triglyceride measurement (EFO:0004530)
 PMID:34887591
GWAS830248_H GCST90133363 Linoleic acid levels 114,999 European ancestry individuals A 0.1 2E-25 24.699 rs1461729 0.07 linoleic acid measurement (EFO:0006807)
 PMID:35692035
GWAS849715_H GCST90269502 LDL cholesterol levels (UKB data field 23405) 88,329 European ancestry individuals A 0.100032 3E-16 15.523 rs1461729 0.0689509 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:36764567
GWAS851660_H GCST90269501 Clinical LDL cholesterol levels (UKB data field 23404) 88,329 European ancestry individuals A 0.100032 6E-16 15.222 rs1461729 0.0680719 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:36764567
GWAS852478_H GCST90269497 Total cholesterol levels (UKB data field 23400) 88,329 European ancestry individuals A 0.100032 5E-24 23.302 rs1461729 0.0827769 total cholesterol measurement (EFO:0004574)
 PMID:36764567
GWAS853341_H GCST90269498 Total cholesterol minus HDL-C levels (UKB data field 23401) 88,329 European ancestry individuals A 0.100032 3E-12 11.523 rs1461729 0.0587276 total cholesterol measurement (EFO:0004574)
 PMID:36764567
GWAS856812_H GCST90269518 Free cholesterol in LDL (UKB data field 23421) 88,329 European ancestry individuals A 0.100032 2E-18 17.699 rs1461729 0.0731983 free cholesterol in LDL measurement (EFO:0022266)
 PMID:36764567
GWAS860275_H GCST90269520 Total lipids in lipoprotein particles (UKB data field 23423) 88,329 European ancestry individuals A 0.100032 8E-18 17.097 rs1461729 0.0713395 total lipids in lipoprotein particles measurement (EFO:0022309)
 PMID:36764567
GWAS866114_H GCST90269625 Free cholesterol in IDL (UKB data field 23528) 88,329 European ancestry individuals A 0.100032 4E-15 14.398 rs1461729 0.064453 free cholesterol in IDL measurement (EFO:0022181)
 PMID:36764567
GWAS866706_H GCST90269623 Cholesterol in IDL (UKB data field 23526) 88,329 European ancestry individuals A 0.100032 1E-17 17 rs1461729 0.0700261 cholesterol in IDL measurement (EFO:0021899)
 PMID:36764567
None Available GCST90269624 Cholesteryl esters in IDL (UKB data field 23527) 88,329 European ancestry individuals A 0.100032 2E-18 17.699 rs1461729 0.0713861 cholesteryl ester measurement (EFO:0010351)
 PMID:36764567
GWAS868565_H GCST90269639 Free cholesterol in medium LDL (UKB data field 23542) 88,329 European ancestry individuals A 0.100032 2E-16 15.699 rs1461729 0.0696806 free cholesterol in medium LDL measurement (EFO:0022268)
 PMID:36764567
None Available GCST90269637 Cholesterol in medium LDL (UKB data field 23540) 88,329 European ancestry individuals A 0.100032 3E-12 11.523 rs1461729 0.0591634 cholesterol in medium LDL measurement (EFO:0022224)
 PMID:36764567
None Available GCST90269638 Cholesteryl esters in medium LDL (UKB data field 23541) 88,329 European ancestry individuals A 0.100032 2E-10 9.699 rs1461729 0.053749 cholesteryl ester measurement (EFO:0010351)
 PMID:36764567
GWAS869077_H GCST90269622 Phospholipids in IDL (UKB data field 23525) 88,329 European ancestry individuals A 0.100032 5E-10 9.302 rs1461729 0.0508765 phospholipids in IDL measurement (EFO:0022164)
 PMID:36764567
GWAS869987_H GCST90269636 Phospholipids in medium LDL (UKB data field 23539) 88,329 European ancestry individuals A 0.100032 4E-12 11.398 rs1461729 0.0586798 phospholipids in medium LDL measurement (EFO:0022183)
 PMID:36764567
None Available GCST90269514 Cholesteryl esters in LDL (UKB data field 23417) 88,329 European ancestry individuals A 0.100032 4E-15 14.398 rs1461729 0.0663075 cholesteryl ester measurement (EFO:0010351)
 PMID:36764567
GWAS871189_H GCST90269512 Total esterified cholesterol levels (UKB data field 23415) 88,329 European ancestry individuals A 0.100032 2E-26 25.699 rs1461729 0.0868331 esterified cholesterol measurement (EFO:0008589)
 PMID:36764567
None Available GCST90269516 Total free cholesterol levels (UKB data field 23419) 88,329 European ancestry individuals A 0.100032 1E-17 17 rs1461729 0.0708315 free cholesterol measurement (EFO:0008591)
 PMID:36764567
GWAS874623_H GCST90269510 Phospholipids in LDL (UKB data field 23413) 88,329 European ancestry individuals A 0.100032 2E-14 13.699 rs1461729 0.0643405 phospholipids in LDL measurement (EFO:0022294)
 PMID:36764567
GWAS886544_H GCST90269543 Polyunsaturated fatty acids levels (UKB data field 23446) 88,268 European ancestry individuals A 0.100045 8E-21 20.097 rs1461729 0.0768351 polyunsaturated fatty acid measurement (EFO:0010733)
 PMID:36764567
GWAS886836_H GCST90269542 Omega-6 fatty acids levels (UKB data field 23445) 88,268 European ancestry individuals A 0.100045 9E-20 19.046 rs1461729 0.0749133 omega-6 polyunsaturated fatty acid measurement (EFO:0005680)
 PMID:36764567
GWAS887100_H GCST90269635 Total lipids in medium LDL (UKB data field 23538) 88,329 European ancestry individuals A 0.100032 2E-11 10.699 rs1461729 0.0566908 total lipids in medium LDL (EFO:0022180)
 PMID:36764567
GWAS888193_H GCST90269632 Free cholesterol in large LDL (UKB data field 23535) 88,329 European ancestry individuals A 0.100032 1E-19 19 rs1461729 0.075332 free cholesterol in large LDL measurement (EFO:0022176)
 PMID:36764567
GWAS897142_H GCST90269546 Linoleic acid levels (UKB data field 23449) 88,268 European ancestry individuals A 0.100045 2E-13 12.699 rs1461729 0.060452 linoleic acid measurement (EFO:0006807)
 PMID:36764567
GWAS898573_H GCST90269644 Cholesterol in small LDL (UKB data field 23547) 88,329 European ancestry individuals A 0.100032 6E-11 10.222 rs1461729 0.0554286 cholesterol in small LDL measurement (EFO:0022227)
 PMID:36764567
GWAS899279_H GCST90269621 Total lipids in IDL (UKB data field 23524) 88,329 European ancestry individuals A 0.100032 5E-14 13.302 rs1461729 0.0616923 total lipids in IDL (EFO:0022161)
 PMID:36764567
None Available GCST90269630 Cholesterol in large LDL (UKB data field 23533) 88,329 European ancestry individuals A 0.100032 2E-18 17.699 rs1461729 0.0734482 cholesterol in large LDL measurement (EFO:0021901)
 PMID:36764567
None Available GCST90269629 Phospholipids in large LDL (UKB data field 23532) 88,329 European ancestry individuals A 0.100032 2E-16 15.699 rs1461729 0.0689897 phospholipids in large LDL measurement (EFO:0022174)
 PMID:36764567
GWAS903100_H GCST90269631 Cholesteryl esters in large LDL (UKB data field 23534) 88,329 European ancestry individuals A 0.100032 9E-18 17.046 rs1461729 0.0719696 cholesteryl ester measurement (EFO:0010351)
 PMID:36764567
GWAS903953_H GCST90269628 Total lipids in large LDL (UKB data field 23531) 88,329 European ancestry individuals A 0.100032 9E-17 16.046 rs1461729 0.0696327 total lipids in large LDL (EFO:0022163)
 PMID:36764567
GWAS904625_H GCST90269522 Total lipids in LDL (UKB data field 23425) 88,329 European ancestry individuals A 0.100032 1E-14 14 rs1461729 0.0650733 total lipids in LDL measurement (EFO:0022308)
 PMID:36764567
GWAS904789_H GCST90269646 Free cholesterol in small LDL (UKB data field 23549) 88,329 European ancestry individuals A 0.100032 3E-13 12.523 rs1461729 0.0614974 free cholesterol in small LDL measurement (EFO:0022271)
 PMID:36764567
None Available GCST90269696 Phospholipids to total lipids in small VLDL percentage (UKB data field 23599) 88,329 European ancestry individuals A 0.100032 3E-12 11.523 rs1461729 0.0567145 phospholipids:total lipids ratio (EFO:0020946)
 PMID:36764567
None Available GCST90269722 Cholesterol to total lipids in small LDL percentage (UKB data field 23625) 88,329 European ancestry individuals A 0.100032 2E-14 13.699 rs1461729 0.0647248 cholesterol to total lipids in small LDL percentage (EFO:0022241)
 PMID:36764567
GWAS993469_H GCST90129603 Chronic elevation of alanine aminotransferase (cALT) levels 23,977 African American cases, 13,387 African American controls A 0.121 2E-9 8.699 rs1461729 0.142 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:35654975
GWAS998137_H GCST90092883 LDL cholesterol levels 115,082 European ancestry individuals A 0.100763 4E-19 18.398 rs1461729 0.0610586 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:35213538
GWAS999633_H GCST90092985 Total cholesterol levels 115,082 European ancestry individuals A 0.100763 2E-29 28.699 rs1461729 0.0749645 total cholesterol measurement (EFO:0004574)
 PMID:35213538
GWAS999653_H GCST90092859 Cholesteryl esters to total lipids ratio in large LDL 115,082 European ancestry individuals A 0.100763 3E-21 20.523 rs1461729 0.0652094 low density lipoprotein cholesterol measurement (EFO:0004611)
cholesteryl esters:total lipids ratio (EFO:0020944)
 PMID:35213538
GWAS999659_H GCST90092858 Cholesteryl ester levels in large LDL 115,082 European ancestry individuals A 0.100763 1E-20 20 rs1461729 0.0632913 cholesteryl ester measurement (EFO:0010351)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:35213538
GWAS999915_H GCST90013663 Alanine aminotransferase levels 387,859 British ancestry individuals, 10,635 Asian or Asian British individuals, 7,468 Black or Black British individuals, 2,338 Chinese ancestry individuals ? NR 8E-29 28.097 rs1461729 0.0093 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:34315874
GWAS999918_H GCST90092986 Total esterified cholesterol levels 115,082 European ancestry individuals A 0.100763 7E-32 31.155 rs1461729 0.0778279 esterified cholesterol measurement (EFO:0008589)
 PMID:35213538
None Available GCST90092860 Free cholesterol levels in large LDL 115,082 European ancestry individuals A 0.100763 4E-19 18.398 rs1461729 0.0603964 free cholesterol measurement (EFO:0008591)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:35213538
GWAS999996_H GCST90295949 Triglyceride to HDL cholesterol ratio 402,398 European ancestry individuals A 0.1015 1E-11 11 rs1461729 0.0354 triglyceride:HDL cholesterol ratio (EFO:0007929)
 PMID:38200128
None Available GCST90092908 Free cholesterol levels in medium LDL 115,082 European ancestry individuals A 0.100763 4E-17 16.398 rs1461729 0.0577885 free cholesterol measurement (EFO:0008591)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:35213538
GWAS1000500_H GCST90092831 Cholesterol levels in IDL 115,082 European ancestry individuals A 0.100763 2E-17 16.699 rs1461729 0.0564393 total cholesterol measurement (EFO:0004574)
intermediate density lipoprotein measurement (EFO:0008595)
 PMID:35213538
GWAS1000796_H GCST90092833 Cholesteryl ester levels in IDL 115,082 European ancestry individuals A 0.100763 1E-18 18 rs1461729 0.0583914 cholesteryl ester measurement (EFO:0010351)
intermediate density lipoprotein measurement (EFO:0008595)
 PMID:35213538
GWAS1000827_H GCST90092864 Phospholipid levels in large LDL 115,082 European ancestry individuals A 0.100763 4E-18 17.398 rs1461729 0.0592574 low density lipoprotein cholesterol measurement (EFO:0004611)
phospholipid measurement (EFO:0004639)
 PMID:35213538
GWAS1001120_H GCST90092856 Cholesterol levels in large LDL 115,082 European ancestry individuals A 0.100763 2E-20 19.699 rs1461729 0.0629907 total cholesterol measurement (EFO:0004574)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:35213538
GWAS1001520_H GCST90092885 Free cholesterol levels in LDL 115,082 European ancestry individuals A 0.100763 5E-18 17.302 rs1461729 0.0588617 free cholesterol measurement (EFO:0008591)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:35213538
GWAS1002476_H GCST90013664 Aspartate aminotransferase levels 386,570 British ancestry individuals, 10,617 Asian or Asian British individuals, 7,426 Black or Black British individuals, 2,321 Chinese ancestry individuals ? NR 7E-13 12.155 rs1461729 0.0045 aspartate aminotransferase measurement (EFO:0004736)
 PMID:34315874
None Available GCST90092837 Total lipid levels in IDL 115,082 European ancestry individuals A 0.100763 2E-14 13.699 rs1461729 0.0509028 lipid measurement (EFO:0004529)
intermediate density lipoprotein measurement (EFO:0008595)
 PMID:35213538
None Available GCST90092957 Cholesterol to total lipids ratio in small LDL 115,082 European ancestry individuals A 0.100763 2E-20 19.699 rs1461729 0.0639405 cholesterol:total lipids ratio (EFO:0020943)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:35213538
GWAS1002769_H GCST90092862 Total lipid levels in large LDL 115,082 European ancestry individuals A 0.100763 6E-19 18.222 rs1461729 0.0604263 low density lipoprotein cholesterol measurement (EFO:0004611)
lipid measurement (EFO:0004529)
 PMID:35213538
GWAS1002977_H GCST90092988 Total free cholesterol levels 115,082 European ancestry individuals A 0.100763 5E-23 22.302 rs1461729 0.0662582 free cholesterol measurement (EFO:0008591)
 PMID:35213538
GWAS1003310_H GCST90092835 Free cholesterol levels in IDL 115,082 European ancestry individuals A 0.100763 9E-14 13.046 rs1461729 0.0495572 free cholesterol measurement (EFO:0008591)
intermediate density lipoprotein measurement (EFO:0008595)
 PMID:35213538
GWAS1004361_H GCST90295951 Triglyceride to HDL cholesterol ratio 216,649 European ancestry individuals A 0.1018 7E-8 7.155 rs1461729 0.0323 triglyceride:HDL cholesterol ratio (EFO:0007929)
 PMID:38200128
None Available GCST90302095 Free cholesterol in small LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1219 2E-18 17.699 rs1461729 0.0549 free cholesterol in small LDL measurement (EFO:0022271)
 PMID:38448586
GWAS1004772_H GCST90302097 Total lipids in small LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.122 7E-17 16.155 rs1461729 0.0526 total lipids in small LDL (EFO:0022168)
 PMID:38448586
GWAS1005564_H GCST90302081 Cholesterol esters in small HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.122 2E-19 18.699 rs1461729 0.0568 esterified cholesterol measurement (EFO:0008589)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS1005593_H GCST90302103 Sphingomyelins levels 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 110,896 European ancestry individuals A 0.1227 1E-23 23 rs1461729 0.0644 sphingomyelin measurement (EFO:0010118)
 PMID:38448586
None Available GCST90302093 Cholesterol esters in small LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1221 7E-17 16.155 rs1461729 0.0526 esterified cholesterol measurement (EFO:0008589)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:38448586
GWAS1005901_H GCST90302071 Polyunsaturated fatty acids 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.122 7E-20 19.155 rs1461729 0.0575 polyunsaturated fatty acid measurement (EFO:0010733)
 PMID:38448586
GWAS1006168_H GCST90302080 Total cholesterol to total lipids ratio in small HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1216 3E-11 10.523 rs1461729 0.0414 cholesterol:total lipids ratio (EFO:0020943)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
None Available GCST90301991 Total cholesterol levels in LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.122 9E-17 16.046 rs1461729 0.0524 total cholesterol measurement (EFO:0004574)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:38448586
GWAS1006709_H GCST90302082 Cholesteryl esters to total lipids ratio in small HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1215 9E-11 10.046 rs1461729 0.0404 cholesteryl esters:total lipids ratio (EFO:0020944)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
None Available GCST90301961 Omega-6 fatty acids levels 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.122 8E-21 20.097 rs1461729 0.059 omega-6 polyunsaturated fatty acid measurement (EFO:0005680)
 PMID:38448586
None Available GCST90302091 Total Cholesterol in small LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1221 2E-17 16.699 rs1461729 0.0534 total cholesterol in small LDL (EFO:0022179)
 PMID:38448586
GWAS1006966_H GCST90302119 Total phosphoglycerides levels 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.122 7E-16 15.155 rs1461729 0.0509 phosphoglycerides measurement (EFO:0022291)
 PMID:38448586
None Available GCST90302098 Concentration of small LDL particles 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1221 2E-16 15.699 rs1461729 0.0516 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:38448586
GWAS1008380_H GCST90302099 Phospholipids in small LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1221 9E-22 21.046 rs1461729 0.0604 phospholipids in small LDL measurement (EFO:0022297)
 PMID:38448586
GWAS1008574_H GCST90302050 Concentration of medium LDL particles 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1221 1E-13 13 rs1461729 0.0466 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:38448586
GWAS1008875_H GCST90302051 Phospholipids in medium LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1221 6E-17 16.222 rs1461729 0.0527 phospholipids in medium LDL measurement (EFO:0022183)
 PMID:38448586
GWAS1009191_H GCST90302043 Total cholesterol in medium LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1221 3E-15 14.523 rs1461729 0.0498 total cholesterol in medium LDL (EFO:0022185)
 PMID:38448586
None Available GCST90302047 Free cholesterol in medium LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.122 2E-17 16.699 rs1461729 0.0533 free cholesterol in medium LDL measurement (EFO:0022268)
 PMID:38448586
None Available GCST90302049 Total lipid levels in medium LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1221 2E-14 13.699 rs1461729 0.0481 low density lipoprotein cholesterol measurement (EFO:0004611)
lipid measurement (EFO:0004529)
 PMID:38448586
GWAS1012860_H GCST90302010 Cholesteryl esters to total lipids ratio in large LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1218 3E-20 19.523 rs1461729 0.058 low density lipoprotein cholesterol measurement (EFO:0004611)
cholesteryl esters:total lipids ratio (EFO:0020944)
 PMID:38448586
None Available GCST90302045 Cholesterol esters in medium LDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.1221 2E-14 13.699 rs1461729 0.0483 cholesterol esters in medium LDL measurement (EFO:0022186)
 PMID:38448586
None Available GCST90179432 Sulfatase-modifying factor 2 levels 2,905 Greek (founder/geneitc isolate) individuals ? NR 3E-12 11.523 rs1461729 0.3731 PMID:36349687
GWAS1025622_H GCST90013405 Liver enzyme levels (alanine transaminase) 437,267 European ancestry individuals A 0.101485 2E-44 43.699 rs1461729 0.00901384 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:33972514
GWAS1028280_H GCST90010361 High density lipoprotein cholesterol levels 29,902 European ancestry individuals A 0.09 4E-9 8.398 rs1461729 1.19 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:31566214
None Available GCST90010363 Total cholesterol levels 29,902 European ancestry individuals A 0.09 2E-11 10.699 rs1461729 3.46 total cholesterol measurement (EFO:0004574)
 PMID:31566214
GWAS1028282_H GCST90010364 Low density lipoprotein cholesterol levels 29,902 European ancestry individuals A 0.09 0.000003 5.523 rs1461729 2.2 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:31566214
None Available GCST90139781 2-hydroxypalmitate levels 6,136 Finnish ancestry individuals G NR 3E-13 12.523 rs1461729 0.17 2-hydroxypalmitate measurement (EFO:0021507)
 PMID:35347128
None Available GCST90140158 Hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH)) levels 6,136 Finnish ancestry individuals G NR 2E-11 10.699 rs1461729 0.16 hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH)) measurement (EFO:0800583)
 PMID:35347128
None Available GCST90239611 High density lipoprotein cholesterol levels 76,531 Taiwanese ancestry individuals ? NR 3E-11 10.523 rs1461729 2.01336 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:36329257
GWAS1038696_H GCST90428729 Alanine aminotransferase levels 1,010,710 European ancestry individuals A NR 6E-51 50.222 rs1461729 0.0096 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:38632349
Database Acc Id Source(s)
GWAS Catalog GCST90092837 GWAS Catalog
  GCST90269510 GWAS Catalog
  GCST90269722 GWAS Catalog
  GCST90302045 GWAS Catalog
  GCST90302049 GWAS Catalog

RGD Curation Notes
Note Type Note Reference