GWAS854612_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS854612_H (insulin measurement QTL GWAS854612 (human)) Homo sapiens

Symbol: GWAS854612_H
Name: insulin measurement QTL GWAS854612 (human)
RGD ID: 407205636
Trait: insulin measurement
Measurement Type: pancreatic islet insulin release measurement   (CMO:0001216)    
LOD Score: Not Available
P Value: 5.0E-7
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381653,460,705 - 53,460,706RGD_MAPPER_PIPELINEGRCh38
GRCh371653,494,617 - 53,494,618RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS854612_HHumanpancreatic islet insulin release measurement  IAGPrs2024449405850206Based on the EFO term IDGWAS_CATALOGPMID:34059833

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS854612_HHumaninsulin measurement  IAGPrs2024449405850206 GWAS_CATALOGPMID:34059833
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
733260RBL2RB transcriptional corepressor like 2165343447153491648Human

Position Markers

Peak: (rs2024449)
Human AssemblyChrPosition (strand)Source
GRCh381653,460,705 - 53,460,706RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407205636GWAS854612_Hinsulin measurement QTL GWAS854612 (human)0.0000005insulin measurementpancreatic islet insulin release measurement (CMO:0001216)165346070553460706Human
407175494GWAS824470_HHeadache, fasting blood insulin measurement QTL GWAS824470 (human)8e-09Headache, fasting blood insulin measurementblood insulin level (CMO:0000349)165346070553460706Human
406991188GWAS640164_Hintelligence QTL GWAS640164 (human)4e-09intelligence165346070553460706Human
407351882GWAS1000858_HBMI-adjusted hip circumference QTL GWAS1000858 (human)2e-10BMI-adjusted hip circumferencehip circumference (CMO:0000014)165346070553460706Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS640164_H GCST006269 General cognitive ability up to 300,486 European ancestry individuals T NR 4E-9 8.398 rs2024449 5.885 intelligence (EFO:0004337)
 PMID:29844566
GWAS824470_H GCST90281120 Headache or fasting insulin levels 84,036 European ancestry headache cases, 335,552 European ancestry controls without headache, 151,903 European ancestry individuals with fasting insulin C NR 8E-9 8.097 rs2024449 0.99 Headache (HP:0002315)
fasting blood insulin measurement (EFO:0004466)
 PMID:36808568
GWAS854612_H GCST90002238 Fasting insulin 151,013 European ancestry individuals T 0.5744 5E-7 6.302 rs2024449 0.01 insulin measurement (EFO:0004467)
 PMID:34059833
GWAS1000858_H GCST012227 Hip circumference adjusted for BMI 186,825 British ancestry men C NR 2E-10 9.699 rs2024449 0.0197216 BMI-adjusted hip circumference (EFO:0008039)
 PMID:34021172
Database Acc Id Source(s)
GWAS Catalog GCST90002238 GWAS Catalog

RGD Curation Notes
Note Type Note Reference