GWAS769818_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS769818_H (type 2 diabetes mellitus QTL GWAS769818 (human)) Homo sapiens

Symbol: GWAS769818_H
Name: type 2 diabetes mellitus QTL GWAS769818 (human)
RGD ID: 407120842
Trait: type 2 diabetes mellitus
LOD Score: Not Available
P Value: 6.0E-10
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38312,351,626 - 12,351,627RGD_MAPPER_PIPELINEGRCh38
GRCh37312,393,125 - 12,393,126RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS769818_HHumantype 2 diabetes mellitus  IAGPrs1801282405850206 GWAS_CATALOGPMID:24509480
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
69168PPARGperoxisome proliferator activated receptor gamma31228736812434344Human

Position Markers

Peak: (rs1801282)
Human AssemblyChrPosition (strand)Source
GRCh38312,351,626 - 12,351,627RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407352518GWAS1001494_Hsex hormone-binding globulin measurement QTL GWAS1001494 (human)2e-21sex hormone-binding globulin measurement31235162612351627Human
407329732GWAS978708_Hsex hormone-binding globulin measurement QTL GWAS978708 (human)3e-67sex hormone-binding globulin measurement31235162612351627Human
407358978GWAS1007954_Hsystolic blood pressure QTL GWAS1007954 (human)0.000008systolic blood pressuresystolic blood pressure (CMO:0000004)31235162612351627Human
407009797GWAS658773_Htype 2 diabetes mellitus QTL GWAS658773 (human)2e-14type 2 diabetes mellitus31235162612351627Human
407358349GWAS1007325_Hpulse pressure measurement QTL GWAS1007325 (human)4e-19pulse pressure measurementpulse pressure (CMO:0000292)31235162612351627Human
407163727GWAS812703_Hbody mass index, fasting blood insulin measurement QTL GWAS812703 (human)0.0000002type 2 diabetes mellitusblood insulin level (CMO:0000349)31235162612351627Human
407287245GWAS936221_Htype 2 diabetes mellitus QTL GWAS936221 (human)1e-16body mass indexbody mass index (BMI) (CMO:0000105)31235162612351627Human
407264714GWAS913690_Hbody mass index QTL GWAS913690 (human)2e-09serum albumin measurementserum albumin level (CMO:0000550)31235162612351627Human
407120842GWAS769818_Htype 2 diabetes mellitus QTL GWAS769818 (human)6e-10type 2 diabetes mellitus31235162612351627Human
407259477GWAS908453_Hsex hormone-binding globulin measurement QTL GWAS908453 (human)3e-28sex hormone-binding globulin measurement31235162612351627Human
407416912GWAS1065888_Hpulse pressure measurement QTL GWAS1065888 (human)8e-14pulse pressure measurementpulse pressure (CMO:0000292)31235162612351627Human
407296094GWAS945070_Hfasting blood insulin measurement QTL GWAS945070 (human)0.0000001type 2 diabetes mellitusblood insulin level (CMO:0000349)31235162612351627Human
407396625GWAS1045601_Htotal blood protein measurement QTL GWAS1045601 (human)2e-26total blood protein measurementblood protein measurement (CMO:0000028)31235162612351627Human
2316345GLUCO224_HGlucose level QTL 224 (human)1.270.008Glucose level3121543441Human
407356441GWAS1005417_Hsystolic blood pressure QTL GWAS1005417 (human)5e-09systolic blood pressuresystolic blood pressure (CMO:0000004)31235162612351627Human
407393835GWAS1042811_Hserum albumin measurement QTL GWAS1042811 (human)2e-41serum albumin measurementserum albumin level (CMO:0000550)31235162612351627Human
407185517GWAS834493_Htriglyceride measurement QTL GWAS834493 (human)5e-26body mass indexbody mass index (BMI) (CMO:0000105)31235162612351627Human
407009067GWAS658043_Htype 2 diabetes mellitus QTL GWAS658043 (human)2e-19type 2 diabetes mellitus31235162612351627Human
407281903GWAS930879_Htype 2 diabetes mellitus QTL GWAS930879 (human)1e-17type 2 diabetes mellitus31235162612351627Human
407387745GWAS1036721_Hsex hormone-binding globulin measurement QTL GWAS1036721 (human)1e-37sex hormone-binding globulin measurement31235162612351627Human
406916971GWAS565947_Htype 2 diabetes mellitus QTL GWAS565947 (human)1e-12type 2 diabetes mellitus31235162612351627Human
406885548GWAS534524_Hsystolic blood pressure QTL GWAS534524 (human)0.0000004systolic blood pressuresystolic blood pressure (CMO:0000004)31235162612351627Human
407236523GWAS885499_Hbody fat percentage QTL GWAS885499 (human)2e-32body fat percentagebody fat percentage (CMO:0000302)31235162612351627Human
407281897GWAS930873_Htype 2 diabetes mellitus QTL GWAS930873 (human)5e-12type 2 diabetes mellitus31235162612351627Human
407350647GWAS999623_Htype 2 diabetes mellitus QTL GWAS999623 (human)1e-09type 2 diabetes mellitus31235162612351627Human
407325686GWAS974662_Hsex hormone-binding globulin measurement QTL GWAS974662 (human)8e-23sex hormone-binding globulin measurement31235162612351627Human
407379003GWAS1027979_Hcalcium measurement QTL GWAS1027979 (human)2e-22calcium measurementblood calcium level (CMO:0000502)31235162612351627Human
407287166GWAS936142_Htype 2 diabetes mellitus QTL GWAS936142 (human)3e-19type 2 diabetes mellitus31235162612351627Human
407128445GWAS777421_Htype 2 diabetes mellitus QTL GWAS777421 (human)0.000002type 2 diabetes mellitus31235162612351627Human
407170750GWAS819726_Hsex hormone-binding globulin measurement QTL GWAS819726 (human)9e-43sex hormone-binding globulin measurement31235162612351627Human
407351098GWAS1000074_Hsex hormone-binding globulin measurement QTL GWAS1000074 (human)2e-11pulse pressure measurementpulse pressure (CMO:0000292)31235162612351627Human
407385783GWAS1034759_Htriglyceride measurement QTL GWAS1034759 (human)2e-20triglyceride measurementblood triglyceride level (CMO:0000118)31235162612351627Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS534524_H GCST90310294 Systolic blood pressure 1,028,980 European ancestry individuals G NR 4E-7 6.398 rs1801282 0.1865 systolic blood pressure (EFO:0006335)
 PMID:38689001
GWAS565947_H GCST005047 Type 2 diabetes 6,377 European ancestry male cases, 5,794 European ancestry female cases, 22,243 European ancestry male controls, 34,619 European ancestry female controls C 0.85520337260229 1E-12 12 rs1801282 1.13 PMID:22885922
None Available GCST90256414 Fasting insulin 8,690 African American individuals, 652 East Asian ancestry individuals, 91,501 European ancestry individuals, 1,142 Hispanic individuals, 2,155 South Asian ancestry individuals G 0.117362 4E-23 22.398 rs1801282 0.031 fasting blood insulin measurement (EFO:0004466)
 PMID:39280063
GWAS658043_H GCST004894 Type 2 diabetes 6,353 South Asian ancestry cases, 7,179 South Asian ancestry controls, 3,871 European ancestry cases, 16,427 European ancestry controls, 34,840 cases, 114,981 controls G 0.1203 2E-19 18.699 rs1801282 0.113 PMID:28869590
GWAS658773_H GCST004894 Type 2 diabetes 6,353 South Asian ancestry cases, 7,179 South Asian ancestry controls, 3,871 European ancestry cases, 16,427 European ancestry controls, 34,840 cases, 114,981 controls G 0.1203 2E-14 13.699 rs1801282 0.1134 PMID:28869590
GWAS769818_H GCST002352 Type 2 diabetes 12,171 European ancestry cases, 56,862 European ancestry controls, 6,952 East Asian ancestry cases, 11,865 East Asian ancestry controls, 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls, 1,804 Mexican ancestry cases, 779 Mexican ancestry controls C 0.88 6E-10 9.222 rs1801282 1.16 PMID:24509480
GWAS777421_H GCST000025 Type 2 diabetes 1,924 European ancestry cases, 2,938 European ancestry controls C NR 0.000002 5.699 rs1801282 1.14 PMID:17463249
None Available GCST000028 Type 2 diabetes 1,464 European ancestry cases, 1,467 European ancestry controls C 0.86 0.000002 5.699 rs1801282 1.14 PMID:17463246
None Available GCST000024 Type 2 diabetes 1,161 European ancestry cases, 1,174 European ancestry controls C 0.82 0.000002 5.699 rs1801282 1.14 PMID:17463248
GWAS812703_H GCST001526 Fasting blood insulin (BMI interaction) Up to 51,750 European ancestry individuals C 0.8725 2E-7 6.699 rs1801282 0.001425 body mass index (EFO:0004340)
fasting blood insulin measurement (EFO:0004466)
 PMID:22581228
GWAS819726_H GCST90012106 Sex hormone-binding globulin levels adjusted for BMI 188,908 European ancestry women G 0.11992899999999995 9E-43 42.046 rs1801282 0.0241704 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS834493_H GCST90239664 Triglyceride levels 1,320,016 European ancestry individuals G 0.124564 5E-26 25.302 rs1801282 0.0270379 triglyceride measurement (EFO:0004530)
 PMID:34887591
None Available GCST90255621 Body mass index 1,122,049 European ancestry individuals G NR 5E-26 25.302 rs1801282 0.0215 body mass index (EFO:0004340)
 PMID:36581621
GWAS885499_H GCST90432180 Body fat percentage (adjusted for testosterone and SHBG) 154,337 British ancestry females ? NR 2E-32 31.699 rs1801282 0.37 body fat percentage (EFO:0007800)
 PMID:37867527
GWAS908453_H GCST90239822 Sex hormone-binding globulin levels 188,443 British ancestry women ? NR 3E-28 27.523 rs1801282 0.0514375 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:36653534
GWAS913690_H GCST006368 Body mass index 315,347 European ancestry individuals, 8,322 Hispanic/Latino individuals, 7,290 East Asian ancestry individuals, 3,069 African American individuals, 459 South Asian ancestry individuals C NR 2E-9 8.699 rs1801282 0.023 body mass index (EFO:0004340)
 PMID:30108127
GWAS930873_H GCST007517 Type 2 diabetes up to 48,286 European ancestry cases, up to 250,671 European ancestry controls C 0.871 5E-12 11.302 rs1801282 1.08 PMID:29632382
GWAS930879_H GCST007515 Type 2 diabetes 48,286 European ancestry cases, 250,671 European ancestry controls, 33,126 African American, East Asian, Hispanic/Latino or South Asian cases, 120,161 African American, East Asian, Hispanic/Latino or South Asian controls C 0.887 1E-17 17 rs1801282 1.09 PMID:29632382
GWAS936142_H GCST007516 Type 2 diabetes (adjusted for BMI) 48,286 European ancestry cases, 250,671 European ancestry controls, 33,126 African American, East Asian, Hispanic/Latino or South Asian cases, 120,161 African American, East Asian, Hispanic/Latino or South Asian controls C 0.887 3E-19 18.523 rs1801282 1.1 PMID:29632382
GWAS936221_H GCST007518 Type 2 diabetes (adjusted for BMI) up to 48,286 European ancestry cases, up to 250,671 European ancestry controls C 0.871 1E-16 16 rs1801282 1.09 PMID:29632382
None Available GCST008129 Body mass index up to 449,889 European ancestry individuals, up to 29,398 South Asian ancestry individuals, up to 27,610 African American individuals, up to 8,839 East Asian individuals, up to 10,772 Hispanic ancestry individuals G 0.11829999999999996 1E-16 16 rs1801282 0.0237 body mass index (EFO:0004340)
 PMID:29273807
GWAS945070_H GCST007857 Fasting blood insulin adjusted for BMI up to 30,825 non-diabetic individuals G NR 1E-7 7 rs1801282 0.025 fasting blood insulin measurement (EFO:0004466)
 PMID:25625282
GWAS974662_H GCST90012107 Sex hormone-binding globulin levels 189,473 European ancestry women G 0.11992899999999995 8E-23 22.097 rs1801282 0.0202851 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS978708_H GCST90012110 Sex hormone-binding globulin levels adjusted for BMI 368,929 European ancestry individuals G 0.12044699999999997 3E-67 66.523 rs1801282 0.021621 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
None Available GCST90093109 Type ii diabetes 16,677 South Asian ancestry cases, 33,856 South Asian ancestry controls C 0.8764 2E-7 6.699 rs1801282 0.1164 PMID:35393509
GWAS999623_H GCST90093110 Type 2 diabetes (adjusted for BMI) 16,677 South Asian ancestry cases, 33,856 South Asian ancestry controls C 0.8764 1E-9 9 rs1801282 0.1409 PMID:35393509
GWAS1000074_H GCST90104277 Sex hormone-binding globulin levels in postmenopausal women 92,911 European ancestry individuals G 0.116992 2E-11 10.699 rs1801282 0.0483349 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
None Available GCST90444202 Type 2 diabetes 51,256 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry cases, 370,487 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry controls G 0.116133 5E-37 36.302 rs1801282 0.1581 PMID:39379762
GWAS1001494_H GCST90104297 Sex hormone-binding globulin levels 4,522 African ancestry individuals, 196,901 European ancestry individuals ? NR 2E-21 20.699 rs1801282 9.495 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
None Available GCST90104273 Sex hormone-binding globulin levels 196,901 European ancestry individuals G 0.116992 2E-21 20.699 rs1801282 0.046662 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:35192695
None Available GCST90086072 Type 2 diabetes 6,967 European ancestry cases, 49,670 European ancestry controls G 0.1202654 1E-7 7 rs1801282 0.86 PMID:33893285
None Available GCST90000061 Pulse pressure 810,865 European ancestry individuals C 0.8759 2E-11 10.699 rs1801282 0.17870705 pulse pressure measurement (EFO:0005763)
 PMID:33230300
GWAS1005417_H GCST90292477 Systolic blood pressure 1,164,961 European ancestry individuals C 0.8767 5E-9 8.302 rs1801282 0.19654442 systolic blood pressure (EFO:0006335)
 PMID:33230300
GWAS1007325_H GCST90292476 Pulse pressure 1,164,961 European ancestry individuals C 0.8766 4E-19 18.398 rs1801282 0.20423386 pulse pressure measurement (EFO:0005763)
 PMID:33230300
GWAS1007954_H GCST90000062 Systolic blood pressure 810,865 European ancestry individuals C 0.876 0.000008 5.097 rs1801282 0.178409 systolic blood pressure (EFO:0006335)
 PMID:33230300
GWAS1027979_H GCST012398 Calcium levels 305,349 European ancestry individuals G 0.1197 2E-22 21.699 rs1801282 0.00332 calcium measurement (EFO:0004838)
 PMID:33887147
None Available GCST90027079 Albumin levels 148,248 British ancestry men G 0.12 2E-9 8.699 rs1801282 0.11 serum albumin measurement (EFO:0004535)
 PMID:34321204
GWAS1034759_H GCST90244680 Triglyceride levels in non-type 2 diabetes 402,944 European ancestry individuals ? NR 2E-20 19.699 rs1801282 N/A triglyceride measurement (EFO:0004530)
 PMID:36269708
GWAS1036721_H GCST90012111 Sex hormone-binding globulin levels 370,125 European ancestry individuals G 0.12044699999999997 1E-37 37 rs1801282 0.0183443 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS1042811_H GCST90018945 Serum albumin levels 315,268 European ancestry individuals, 120,539 East Asian ancestry individuals G NR 2E-41 40.699 rs1801282 0.0481 serum albumin measurement (EFO:0004535)
 PMID:34594039
GWAS1045601_H GCST90018976 Serum total protein levels 314,921 European ancestry individuals, 133,321 East Asian ancestry individuals G NR 2E-26 25.699 rs1801282 0.0386 total blood protein measurement (EFO:0004536)
 PMID:34594039
GWAS1065888_H GCST90310296 Pulse pressure 1,028,980 European ancestry individuals G NR 8E-14 13.097 rs1801282 0.1955 pulse pressure measurement (EFO:0005763)
 PMID:38689001
Database Acc Id Source(s)
GWAS Catalog GCST002352 GWAS Catalog

RGD Curation Notes
Note Type Note Reference