GWAS717022_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS717022_H (low density lipoprotein cholesterol measurement QTL GWAS717022 (human)) Homo sapiens

Symbol: GWAS717022_H
Name: low density lipoprotein cholesterol measurement QTL GWAS717022 (human)
RGD ID: 407068046
Trait: low density lipoprotein cholesterol measurement
Measurement Type: blood low density lipoprotein cholesterol level   (CMO:0000053)    
LOD Score: Not Available
P Value: 2.0E-8
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38472,625,905 - 72,625,906RGD_MAPPER_PIPELINEGRCh38
GRCh37473,491,622 - 73,491,623RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS717022_HHumanblood low density lipoprotein cholesterol level  IAGPrs537526354405850206Based on the EFO term IDGWAS_CATALOGPMID:29084231

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS717022_HHumanlow density lipoprotein cholesterol measurement  IAGPrs537526354405850206 GWAS_CATALOGPMID:29084231
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Position Markers

Peak: (rs537526354)
Human AssemblyChrPosition (strand)Source
GRCh38472,625,905 - 72,625,906RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407311894GWAS960870_Hlow density lipoprotein cholesterol measurement QTL GWAS960870 (human)5e-66low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)47262590572625906Human
407292884GWAS941860_Hlow density lipoprotein cholesterol measurement QTL GWAS941860 (human)4e-57low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)47262590572625906Human
407293138GWAS942114_Htotal cholesterol measurement QTL GWAS942114 (human)3e-88total cholesterol measurementblood total cholesterol level (CMO:0000051)47262590572625906Human
407068053GWAS717029_Hlow density lipoprotein cholesterol measurement QTL GWAS717029 (human)4e-08low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)47262590572625906Human
407141970GWAS790946_Hvery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio QTL GWAS790946 (human)3e-10very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratioblood very low density lipoprotein cholesterol level (CMO:0000648)47262590572625906Human
407068532GWAS717508_Hlow density lipoprotein cholesterol measurement QTL GWAS717508 (human)2e-09low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)47262590572625906Human
407316575GWAS965551_Hnon-high density lipoprotein cholesterol measurement QTL GWAS965551 (human)2e-62non-high density lipoprotein cholesterol measurementblood non-high density lipoprotein cholesterol level (CMO:0003967)47262590572625906Human
407319951GWAS968927_Hnon-high density lipoprotein cholesterol measurement QTL GWAS968927 (human)7e-53non-high density lipoprotein cholesterol measurementblood non-high density lipoprotein cholesterol level (CMO:0003967)47262590572625906Human
407327486GWAS976462_Htotal cholesterol measurement QTL GWAS976462 (human)3e-73total cholesterol measurementblood total cholesterol level (CMO:0000051)47262590572625906Human
407069327GWAS718303_Hlow density lipoprotein cholesterol measurement QTL GWAS718303 (human)1e-09low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)47262590572625906Human
407068046GWAS717022_Hlow density lipoprotein cholesterol measurement QTL GWAS717022 (human)2e-08low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)47262590572625906Human
407068060GWAS717036_Hesterified cholesterol measurement, low density lipoprotein cholesterol measurement QTL GWAS717036 (human)3e-08esterified cholesterol measurement, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)47262590572625906Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS717022_H GCST005486 Medium LDL particle concentration 8,372 Finnish ancestry males ? NR 2E-8 7.699 rs537526354 0.5 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:29084231
GWAS717029_H GCST005488 Total cholesterol levels in medium LDL 8,372 Finnish ancestry males ? NR 4E-8 7.398 rs537526354 0.5 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:29084231
GWAS717036_H GCST005489 Cholesterol ester levels in medium LDL 8,372 Finnish ancestry males ? NR 3E-8 7.523 rs537526354 0.5 esterified cholesterol measurement (EFO:0008589)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:29084231
GWAS717508_H GCST005491 Total cholesterol levels in small LDL 8,372 Finnish ancestry males ? NR 2E-9 8.699 rs537526354 0.5 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:29084231
GWAS718303_H GCST005490 Small LDL particle concentration 8,372 Finnish ancestry males ? NR 1E-9 9 rs537526354 0.5 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:29084231
GWAS790946_H GCST90302143 Free cholesterol to total lipids ratio in very large VLDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 110,896 European ancestry individuals A 0.0155 3E-10 9.523 rs537526354 0.2339 very low density lipoprotein cholesterol measurement (EFO:0008317)
free cholesterol:total lipids ratio (EFO:0020945)
 PMID:38448586
GWAS941860_H GCST90239658 Low density lipoprotein cholesterol levels 1,320,016 European ancestry individuals A 0.00177598 4E-57 56.398 rs537526354 0.399372 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34887591
GWAS942114_H GCST90239673 Total cholesterol levels 40,963 South Asian ancestry individuals, 48,057 Hispanic individuals, 99,432 Admixed African or African ancestry individuals, 146,492 East Asian ancestry individuals, 1,320,016 European ancestry individuals ? NR 3E-88 87.523 rs537526354 N/A total cholesterol measurement (EFO:0004574)
 PMID:34887591
GWAS960870_H GCST90239655 Low density lipoprotein cholesterol levels 40,963 South Asian ancestry individuals, 48,057 Hispanic individuals, 99,432 Admixed African or African ancestry individuals, 146,492 East Asian ancestry individuals, 1,320,016 European ancestry individuals ? NR 5E-66 65.302 rs537526354 N/A low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34887591
GWAS965551_H GCST90239667 Non-HDL cholesterol levels 40,963 South Asian ancestry individuals, 48,057 Hispanic individuals, 99,432 Admixed African or African ancestry individuals, 146,492 East Asian ancestry individuals, 1,320,016 European ancestry individuals ? NR 2E-62 61.699 rs537526354 N/A non-high density lipoprotein cholesterol measurement (EFO:0005689)
 PMID:34887591
GWAS968927_H GCST90239670 Non-HDL cholesterol levels 1,320,016 European ancestry individuals A 0.0017565 7E-53 52.155 rs537526354 0.400895 non-high density lipoprotein cholesterol measurement (EFO:0005689)
 PMID:34887591
GWAS976462_H GCST90239676 Total cholesterol levels 1,320,016 European ancestry individuals A 0.00172476 3E-73 72.523 rs537526354 0.459321 total cholesterol measurement (EFO:0004574)
 PMID:34887591
Database Acc Id Source(s)
GWAS Catalog GCST005486 GWAS Catalog

RGD Curation Notes
Note Type Note Reference