GWAS708801_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS708801_H (systolic blood pressure, alcohol consumption measurement QTL GWAS708801 (human)) Homo sapiens

Symbol: GWAS708801_H
Name: systolic blood pressure, alcohol consumption measurement QTL GWAS708801 (human)
RGD ID: 407059825
Trait: systolic blood pressure, alcohol consumption measurement
Measurement Type: ethanol drink intake rate   (CMO:0001407)    
systolic blood pressure   (CMO:0000004)    
LOD Score: Not Available
P Value: 9.0E-13
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38110,736,490 - 10,736,491RGD_MAPPER_PIPELINEGRCh38
GRCh37110,796,547 - 10,796,548RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS708801_HHumanethanol drink intake rate  IAGPrs17035646405850206Based on the EFO term IDGWAS_CATALOGPMID:29912962
GWAS708801_HHumansystolic blood pressure  IAGPrs17035646405850206Based on the EFO term IDGWAS_CATALOGPMID:29912962

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS708801_HHumanalcohol consumption measurement  IAGPrs17035646405850206 GWAS_CATALOGPMID:29912962
GWAS708801_HHumansystolic blood pressure  IAGPrs17035646405850206 GWAS_CATALOGPMID:29912962
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1606535CASZ1castor zinc finger 111063660410796646Human
38674269LOC110121258VISTA enhancer hs209411073482110739184Human

Position Markers

Peak: (rs17035646)
Human AssemblyChrPosition (strand)Source
GRCh38110,736,490 - 10,736,491RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
407392012GWAS1040988_HCalcium channel blocker use measurement QTL GWAS1040988 (human)9e-19Calcium channel blocker use measurement11073649010736491Human
406984900GWAS633876_Hsystolic blood pressure QTL GWAS633876 (human)4e-36systolic blood pressuresystolic blood pressure (CMO:0000004)11073649010736491Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
407393860GWAS1042836_Hmean arterial pressure QTL GWAS1042836 (human)8e-18mean arterial pressuremean arterial blood pressure (CMO:0000009)11073649010736491Human
407395972GWAS1044948_Hsystolic blood pressure QTL GWAS1044948 (human)3e-32systolic blood pressuresystolic blood pressure (CMO:0000004)11073649010736491Human
407053774GWAS702750_Hdiastolic blood pressure, alcohol consumption measurement QTL GWAS702750 (human)1e-11diastolic blood pressure, alcohol consumption measurementethanol drink intake rate (CMO:0001407)11073649010736491Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
407063186GWAS712162_Hpulse pressure measurement, alcohol drinking QTL GWAS712162 (human)2e-20pulse pressure measurement, alcohol drinkingpulse pressure (CMO:0000292)11073649010736491Human
407417371GWAS1066347_Hdiastolic blood pressure QTL GWAS1066347 (human)1e-59diastolic blood pressurediastolic blood pressure (CMO:0000005)11073649010736491Human
407396635GWAS1045611_HAntihypertensive use measurement QTL GWAS1045611 (human)8e-13Antihypertensive use measurement11073649010736491Human
407059157GWAS708133_Hsystolic blood pressure, alcohol drinking QTL GWAS708133 (human)1e-36systolic blood pressure, alcohol drinkingsystolic blood pressure (CMO:0000004)11073649010736491Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
407392663GWAS1041639_Hsystolic blood pressure QTL GWAS1041639 (human)5e-20systolic blood pressuresystolic blood pressure (CMO:0000004)11073649010736491Human
407397033GWAS1046009_Hsystolic blood pressure QTL GWAS1046009 (human)8e-72systolic blood pressuresystolic blood pressure (CMO:0000004)11073649010736491Human
407070565GWAS719541_Hmean arterial pressure, alcohol consumption measurement QTL GWAS719541 (human)5e-14mean arterial pressure, alcohol consumption measurementethanol drink intake rate (CMO:0001407)11073649010736491Human
407251183GWAS900159_Hsystolic blood pressure QTL GWAS900159 (human)7e-11systolic blood pressuresystolic blood pressure (CMO:0000004)11073649010736491Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human
407392678GWAS1041654_Hpulse pressure measurement QTL GWAS1041654 (human)1e-10pulse pressure measurementpulse pressure (CMO:0000292)11073649010736491Human
407059825GWAS708801_Hsystolic blood pressure, alcohol consumption measurement QTL GWAS708801 (human)9e-13systolic blood pressure, alcohol consumption measurementethanol drink intake rate (CMO:0001407)11073649010736491Human
407389882GWAS1038858_Hsystolic blood pressure QTL GWAS1038858 (human)2e-16systolic blood pressuresystolic blood pressure (CMO:0000004)11073649010736491Human
407083376GWAS732352_Hurinary albumin to creatinine ratio QTL GWAS732352 (human)1e-08urinary albumin to creatinine ratiourine albumin level to urine creatinine level ratio (CMO:0000384)11073649010736491Human
407084656GWAS733632_Hsystolic blood pressure QTL GWAS733632 (human)2e-33systolic blood pressuresystolic blood pressure (CMO:0000004)11073649010736491Human
407061941GWAS710917_Hsystolic blood pressure, alcohol consumption measurement QTL GWAS710917 (human)7e-14systolic blood pressure, alcohol consumption measurementethanol drink intake rate (CMO:0001407)11073649010736491Human
407174451GWAS823427_Hlymphocyte count QTL GWAS823427 (human)4e-09lymphocyte countblood lymphocyte count (CMO:0000031)11073649010736491Human
407399679GWAS1048655_Hpulse pressure measurement QTL GWAS1048655 (human)1e-18pulse pressure measurementpulse pressure (CMO:0000292)11073649010736491Human
407399601GWAS1048577_Hmean arterial pressure QTL GWAS1048577 (human)3e-28mean arterial pressuremean arterial blood pressure (CMO:0000009)11073649010736491Human
407354618GWAS1003594_Hdiastolic blood pressure QTL GWAS1003594 (human)3e-19diastolic blood pressurediastolic blood pressure (CMO:0000005)11073649010736491Human
407415926GWAS1064902_Hpulse pressure measurement QTL GWAS1064902 (human)6e-29pulse pressure measurementpulse pressure (CMO:0000292)11073649010736491Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS633876_H GCST007087 Systolic blood pressure approximately 422,000 European ancestry individuals ? NR 4E-36 35.398 rs17035646 N/A systolic blood pressure (EFO:0006335)
 PMID:30595370
GWAS702750_H GCST006169 Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) 12,758 European ancestry heavy drinkers, 1,326 African American or Afro-Caribbean heavy drinkers, 648 Asian ancestry heavy drinkers, 364 Hispanic or Latin American heavy drinkers, 43,947 European ancestry light drinkers, 8,239 African American or Afro-Caribbean light drinkers, 1,141 Asian ancestry light drinkers, 4,448 Hispanic or Latin American light drinkers A 0.34 1E-11 11 rs17035646 N/A diastolic blood pressure (EFO:0006336)
alcohol consumption measurement (EFO:0007878)
 PMID:29912962
GWAS708133_H GCST006434 Systolic blood pressure x alcohol consumption interaction (2df test) 63,608 European ancestry drinkers, 10,193 African American or Afro-Caribbean heavy drinkers, 2,441 Asian ancestry drinkers, 5,084 Hispanic or Latin American drinkers, 27,494 European ancestry non-drinkers, 11,224 African American or Afro-Caribbean non-drinkers, 9,924 Asian ancestry non-drinkers, 3,387 Hispanic or Latin American non-drinkers A 0.34 1E-36 36 rs17035646 N/A systolic blood pressure (EFO:0006335)
alcohol drinking (EFO:0004329)
 PMID:29912962
GWAS708801_H GCST006170 Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) 12,758 European ancestry heavy drinkers, 1,326 African American or Afro-Caribbean heavy drinkers, 648 Asian ancestry heavy drinkers, 364 Hispanic or Latin American heavy drinkers, 43,947 European ancestry light drinkers, 8,239 African American or Afro-Caribbean light drinkers, 1,141 Asian ancestry light drinkers, 4,448 Hispanic or Latin American light drinkers A 0.34 9E-13 12.046 rs17035646 N/A systolic blood pressure (EFO:0006335)
alcohol consumption measurement (EFO:0007878)
 PMID:29912962
GWAS710917_H GCST006170 Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) 12,758 European ancestry heavy drinkers, 1,326 African American or Afro-Caribbean heavy drinkers, 648 Asian ancestry heavy drinkers, 364 Hispanic or Latin American heavy drinkers, 43,947 European ancestry light drinkers, 8,239 African American or Afro-Caribbean light drinkers, 1,141 Asian ancestry light drinkers, 4,448 Hispanic or Latin American light drinkers A 0.34 7E-14 13.155 rs17035646 N/A systolic blood pressure (EFO:0006335)
alcohol consumption measurement (EFO:0007878)
 PMID:29912962
GWAS712162_H GCST006168 Pulse pressure x alcohol consumption interaction (2df test) 91,099 European ancestry drinkers and non-drinkers, 21,416 African American or Afro-Caribbean drinkers and non-drinkers, 12,365 Asian ancestry drinkers and non-drinkers, 8,470 Hispanic or Latin American drinkers and non-drinkers A 0.35 2E-20 19.699 rs17035646 N/A pulse pressure measurement (EFO:0005763)
alcohol drinking (EFO:0004329)
 PMID:29912962
GWAS719541_H GCST006172 Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) 56,705 European ancestry heavy and light drinkers, 9,725 African American or Afro-Caribbean heavy and light drinkers, 1,789 Asian ancestry heavy and light drinkers, 4,812 Hispanic or Latin American heavy and light drinkers A 0.34 5E-14 13.302 rs17035646 N/A mean arterial pressure (EFO:0006340)
alcohol consumption measurement (EFO:0007878)
 PMID:29912962
GWAS732352_H GCST008794 Urinary albumin-to-creatinine ratio 547,361 European ancestry individuals A 0.3398 1E-8 8 rs17035646 0.0120302 urinary albumin to creatinine ratio (EFO:0007778)
 PMID:31511532
GWAS733632_H GCST007267 Systolic blood pressure 365,998 European ancestry individuals, 63,490 African ancestry individuals, 22,802 Hispanic individuals, 4,792 Asian ancestry individuals, 2,695 Native American ancestry individuals A 0.3372 2E-33 32.699 rs17035646 0.4161 systolic blood pressure (EFO:0006335)
 PMID:30578418
GWAS823427_H GCST90002388 Lymphocyte count 408,112 British individuals A 0.337824 4E-9 8.398 rs17035646 0.013834883 lymphocyte count (EFO:0004587)
 PMID:32888494
GWAS900159_H GCST90301696 Systolic blood pressure 174,664 British ancestry females G NR 7E-11 10.155 rs17035646 0.02 systolic blood pressure (EFO:0006335)
 PMID:38459180
GWAS1003594_H GCST90018952 Diastolic blood pressure 340,162 European ancestry individuals, 145,515 East Asian ancestry individuals A NR 3E-19 18.523 rs17035646 0.0188 diastolic blood pressure (EFO:0006336)
 PMID:34594039
GWAS1038858_H GCST90301695 Systolic blood pressure 349,328 British ancestry individuals G NR 2E-16 15.699 rs17035646 0.02 systolic blood pressure (EFO:0006335)
 PMID:38459180
GWAS1040988_H GCST90018767 Medication use (calcium channel blockers) 49,327 East Asian ancestry cases, 129,399 East Asian ancestry controls A 0.676890894 9E-19 18.046 rs17035646 0.07768616 Calcium channel blocker use measurement (EFO:0009930)
 PMID:34594039
GWAS1041639_H GCST90018752 Systolic blood pressure 145,505 East Asian ancestry individuals A 0.676279 5E-20 19.302 rs17035646 0.0327724 systolic blood pressure (EFO:0006335)
 PMID:34594039
GWAS1041654_H GCST90018750 Pulse pressure 145,445 East Asian ancestry individuals A 0.676293 1E-10 10 rs17035646 0.0232963 pulse pressure measurement (EFO:0005763)
 PMID:34594039
GWAS1042836_H GCST90018743 Mean arterial pressure 145,502 East Asian ancestry individuals A 0.676294 8E-18 17.097 rs17035646 0.031543 mean arterial pressure (EFO:0006340)
 PMID:34594039
GWAS1044948_H GCST90018972 Systolic blood pressure 340,159 European ancestry individuals, 145,505 East Asian ancestry individuals A NR 3E-32 31.523 rs17035646 0.0235 systolic blood pressure (EFO:0006335)
 PMID:34594039
GWAS1045611_H GCST90018984 Medication use (antihypertensives) 6,431 European ancestry cases, 145,949 European ancestry controls, 5,688 East Asian ancestry cases, 173,038 East Asian ancestry controls A NR 8E-13 12.097 rs17035646 0.1001 Antihypertensive use measurement (EFO:0009927)
 PMID:34594039
GWAS1046009_H GCST90310294 Systolic blood pressure 1,028,980 European ancestry individuals A NR 8E-72 71.097 rs17035646 0.4588 systolic blood pressure (EFO:0006335)
 PMID:38689001
GWAS1048577_H GCST90018963 Mean arterial pressure 360,863 European ancestry individuals, 145,502 East Asian ancestry individuals A NR 3E-28 27.523 rs17035646 0.0223 mean arterial pressure (EFO:0006340)
 PMID:34594039
GWAS1048655_H GCST90018970 Pulse pressure 360,863 European ancestry individuals, 145,445 East Asian ancestry individuals A NR 1E-18 18 rs17035646 0.017 pulse pressure measurement (EFO:0005763)
 PMID:34594039
None Available GCST90435415 Systolic blood pressure 404,507 European ancestry individuals ? NR 3E-32 31.523 rs17035646 0.0241981 systolic blood pressure (EFO:0006335)
 PMID:39134668
None Available GCST90446217 Major depressive disorder or urinary albumin-to-creatinine ratio (MTAG) 172,705 European ancestry individuals with major depressive disorder measurements, 288,649 European ancestry individuals with UACR measurements ? NR 1E-8 8 rs17035646 N/A urinary albumin to creatinine ratio (EFO:0007778)
 PMID:38858783
GWAS1064902_H GCST90310296 Pulse pressure 1,028,980 European ancestry individuals A NR 6E-29 28.222 rs17035646 0.204 pulse pressure measurement (EFO:0005763)
 PMID:38689001
GWAS1066347_H GCST90310295 Diastolic blood pressure 1,028,980 European ancestry individuals A NR 1E-59 59 rs17035646 0.2596 diastolic blood pressure (EFO:0006336)
 PMID:38689001
Database Acc Id Source(s)
GWAS Catalog GCST006170 GWAS Catalog

RGD Curation Notes
Note Type Note Reference