GWAS704217_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS704217_H (mean corpuscular hemoglobin concentration QTL GWAS704217 (human)) Homo sapiens

Symbol: GWAS704217_H
Name: mean corpuscular hemoglobin concentration QTL GWAS704217 (human)
RGD ID: 407055241
Trait: body lean mass   (VT:0010483)    
Measurement Type: mean corpuscular hemoglobin concentration   (CMO:0000291)    
total body lean mass   (CMO:0003950)    
LOD Score: Not Available
P Value: 1.0E-11
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381543,735,849 - 43,735,850RGD_MAPPER_PIPELINEGRCh38
GRCh371544,028,047 - 44,028,048RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS704217_HHumanmean corpuscular hemoglobin concentration  IAGPrs147233090405850206Based on the EFO term IDGWAS_CATALOGPMID:32888493
GWAS704217_HHumantotal body lean mass  IAGPrs147233090405850206Based on the EFO term IDGWAS_CATALOGPMID:38538606

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS704217_HHumanbody lean mass  IAGPrs147233090405850206Based on the EFO term IDGWAS_CATALOGPMID:38538606

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS704217_HHumanlean body mass  IAGPrs147233090405850206 GWAS_CATALOGPMID:38538606
GWAS704217_HHumanmean corpuscular hemoglobin concentration  IAGPrs147233090405850206 GWAS_CATALOGPMID:32888493
Experimental Data Annotations     Click to see Annotation Detail View

Vertebrate Trait
body lean mass  (IAGP)

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Position Markers

Peak: (rs147233090)
Human AssemblyChrPosition (strand)Source
GRCh381543,735,849 - 43,735,850RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407055241GWAS704217_Hmean corpuscular hemoglobin concentration QTL GWAS704217 (human)1e-11body lean mass (VT:0010483)total body lean mass (CMO:0003950)154373584943735850Human
407369485GWAS1018461_Hhemoglobin measurement QTL GWAS1018461 (human)7e-15hemoglobin measurementhemoglobin measurement (CMO:0000508)154373584943735850Human
406955981GWAS604957_Halpha-2-macroglobulin measurement QTL GWAS604957 (human)2e-17alpha-2-macroglobulin measurement154373584943735850Human
1643273BW330_HBody Weight QTL 330 (human)1.050.014Body weightbody mass index152686671952866719Human
407414108GWAS1063084_Hserum albumin measurement QTL GWAS1063084 (human)4e-81serum albumin measurementserum albumin level (CMO:0000550)154373584943735850Human
2299958PRSTS330_HProstate tumor susceptibility QTL 330 (human)1.020.0151Prostate tumor susceptibility153479023060790230Human
407089622GWAS738598_Htriglyceride measurement QTL GWAS738598 (human)3e-10triglyceride measurementblood triglyceride level (CMO:0000118)154373584943735850Human
407381726GWAS1030702_Hmean corpuscular hemoglobin concentration QTL GWAS1030702 (human)2e-10high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)154373584943735850Human
407406494GWAS1055470_Hmonocyte percentage of leukocytes QTL GWAS1055470 (human)2e-16monocyte percentage of leukocytesblood monocyte count to total leukocyte count ratio (CMO:0000374)154373584943735850Human
407411281GWAS1060257_Hcholesterol:total lipids ratio, low density lipoprotein cholesterol measurement QTL GWAS1060257 (human)2e-28cholesterol:total lipids ratio, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)154373584943735850Human
1643523BW284_HBody Weight QTL 284 (human)1.950.0013Body weight152179288947792889Human
407135769GWAS784745_Hhigh density lipoprotein cholesterol measurement QTL GWAS784745 (human)4e-11high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)154373584943735850Human
406942876GWAS591852_Hfetuin-B measurement QTL GWAS591852 (human)2e-21fetuin-B measurement154373584943735850Human
2289410BW327_HBody weight QTL 327 (human)3.320.0001Body fat amount151998012945980129Human
407415976GWAS1064952_Hcholesteryl ester measurement, high density lipoprotein cholesterol measurement QTL GWAS1064952 (human)3e-12blood lipid amount (VT:0003949)blood high density lipoprotein cholesterol level (CMO:0000052)154373584943735850Human
407419497GWAS1068473_Hcitrate measurement QTL GWAS1068473 (human)1e-23citrate measurement154373584943735850Human
1559411SCL107_HSerum cholesterol level QTL 107 (human)3.88Lipid leveltriglyceride152654355252543552Human
407378350GWAS1027326_Hhemoglobin measurement QTL GWAS1027326 (human)8e-35hemoglobin measurementhemoglobin measurement (CMO:0000508)154373584943735850Human
407370016GWAS1018992_Hhematocrit QTL GWAS1018992 (human)5e-10hematocrithematocrit (CMO:0000037)154373584943735850Human
407364576GWAS1013552_Hcalcium measurement QTL GWAS1013552 (human)1e-33calcium measurementblood calcium level (CMO:0000502)154373584943735850Human
407264801GWAS913777_Hlipoprotein-associated phospholipase A(2) measurement QTL GWAS913777 (human)4e-08lipoprotein-associated phospholipase A(2) measurement154373584943735850Human
407034090GWAS683066_Hlinoleic acid measurement QTL GWAS683066 (human)1e-13linoleic acid measurementblood free fatty acids level (CMO:0000117)154373584943735850Human
407410788GWAS1059764_Hfatty acid measurement, linoleic acid measurement QTL GWAS1059764 (human)3e-17fatty acid measurement, linoleic acid measurementblood free fatty acids level (CMO:0000117)154373584943735850Human
1559354LDLPS4_HLow density lipoprotein particle size QTL 4 (human)2.20.019LDL particle size153479023060790230Human
407060654GWAS709630_Hmean corpuscular hemoglobin QTL GWAS709630 (human)5e-21mean corpuscular hemoglobinmean corpuscular hemoglobin (CMO:0000290)154373584943735850Human
407372325GWAS1021301_Htriglyceride measurement, physical activity QTL GWAS1021301 (human)1e-26triglyceride measurement, physical activityblood triglyceride level (CMO:0000118)154373584943735850Human
2289420BW314_HBody weight QTL 314 (human)2.720.0003Body weightlean mass151998012945980129Human
407024493GWAS673469_Hcholesterol to total lipids in large LDL percentage QTL GWAS673469 (human)5e-22cholesterol to total lipids in large LDL percentage 154373584943735850Human
2289430BMD7_HBone mineral density QTL 7 (human)3.320.0001Bone mineral density151998012945980129Human
407418160GWAS1067136_Hmean corpuscular hemoglobin QTL GWAS1067136 (human)4e-15mean corpuscular hemoglobinmean corpuscular hemoglobin (CMO:0000290)154373584943735850Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS591852_H GCST90247575 Fetuin-B levels 10,708 European ancestry individuals T 0.03 2E-21 20.699 rs147233090 0.389 fetuin-B measurement (EFO:0008128)
 PMID:34648354
GWAS604957_H GCST90246397 Alpha-2-macroglobulin levels 10,708 European ancestry individuals T 0.03 2E-17 16.699 rs147233090 0.329 alpha-2-macroglobulin measurement (EFO:0020138)
 PMID:34648354
GWAS673469_H GCST90269712 Cholesterol to total lipids in large LDL percentage (UKB data field 23615) 88,329 European ancestry individuals T 0.0244311 5E-22 21.302 rs147233090 0.144571 cholesterol to total lipids in large LDL percentage (EFO:0022235)
 PMID:36764567
GWAS683066_H GCST90269553 Linoleic acid to total fatty acids percentage (UKB data field 23456) 88,268 European ancestry individuals T 0.024431 1E-13 13 rs147233090 0.110522 linoleic acid measurement (EFO:0006807)
 PMID:36764567
GWAS704217_H GCST90002328 Mean corpuscular hemoglobin concentration 491,553 European ancestry individuals T 0.024713 1E-11 11 rs147233090 0.044073 mean corpuscular hemoglobin concentration (EFO:0004528)
 PMID:32888493
GWAS709630_H GCST007068 Mean corpuscular hemoglobin approximately 443,000 European ancestry individuals ? NR 5E-21 20.302 rs147233090 N/A mean corpuscular hemoglobin (EFO:0004527)
 PMID:30595370
GWAS738598_H GCST011345 Triglyceride levels 76,081 European ancestry individuals, 127,395 Japanese ancestry individuals ? NR 3E-10 9.523 rs147233090 0.1209 triglyceride measurement (EFO:0004530)
 PMID:33339817
GWAS784745_H GCST90302133 Concentration of very large HDL particles 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals T 0.0242 4E-11 10.398 rs147233090 0.1023 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS913777_H GCST004963 Lipoprotein phospholipase A2 activity in cardiovascular disease 22,156 European, Asian, African, Arabic, Native American, Pacific Islander and other ancestry T 0.0299 4E-8 7.398 rs147233090 7.2 lipoprotein-associated phospholipase A(2) measurement (EFO:0004746)
 PMID:28753643
None Available GCST90428120 Whole body fat free mass (UKB data field 23101) 337,739 European ancestry individuals T NR 1E-11 11 rs147233090 0.0289876 lean body mass (EFO:0004995)
 PMID:38538606
GWAS1013552_H GCST012398 Calcium levels 305,349 European ancestry individuals T 0.02481 1E-33 33 rs147233090 0.008869 calcium measurement (EFO:0004838)
 PMID:33887147
GWAS1018461_H GCST004615 Hemoglobin concentration 172,925 European ancestry individuals T 0.0241 7E-15 14.155 rs147233090 0.0928193 hemoglobin measurement (EFO:0004509)
 PMID:27863252
GWAS1018992_H GCST004604 Hematocrit 173,039 European ancestry individuals T 0.0241 5E-10 9.302 rs147233090 0.073863 hematocrit (EFO:0004348)
 PMID:27863252
GWAS1021301_H GCST007286 Triglycerides x physical activity interaction (2df test) 7,294 African American inactive individuals, 12,832 African American active individuals, 1,352 Asian ancestry inactive individuals, 3,049 Asian ancestry active individuals, 20,622 European ancestry inactive individuals, 51,480 European ancestry active individuals, 2,166 Hispanic or Latin American inactive individuals, 3,486 Hispanic or Latin American active individuals T 0.0267 1E-26 26 rs147233090 N/A triglyceride measurement (EFO:0004530)
physical activity (EFO:0003940)
 PMID:30670697
GWAS1027326_H GCST010083 Hemoglobin levels 684,122 European ancestry individuals T NR 8E-35 34.097 rs147233090 0.085 hemoglobin measurement (EFO:0004509)
 PMID:32327693
GWAS1030702_H GCST90002332 Mean corpuscular hemoglobin concentration 642,173 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals T 0.0239279 2E-10 9.699 rs147233090 N/A mean corpuscular hemoglobin concentration (EFO:0004528)
 PMID:32888493
GWAS1055470_H GCST90002394 Monocyte percentage of white cells 408,112 British individuals T 0.024521 2E-16 15.699 rs147233090 0.05962519 monocyte percentage of leukocytes (EFO:0007989)
 PMID:32888494
GWAS1059764_H GCST90092881 Ratio of linoleic acid to total fatty acids 115,006 European ancestry individuals C 0.975416 3E-17 16.523 rs147233090 0.10949 fatty acid measurement (EFO:0005110)
linoleic acid measurement (EFO:0006807)
 PMID:35213538
GWAS1060257_H GCST90092857 Cholesterol to total lipids ratio in large LDL 115,082 European ancestry individuals C 0.97542 2E-28 27.699 rs147233090 0.144105 cholesterol:total lipids ratio (EFO:0020943)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:35213538
GWAS1063084_H GCST90018945 Serum albumin levels 315,268 European ancestry individuals, 120,539 East Asian ancestry individuals T NR 4E-81 80.398 rs147233090 0.1534 serum albumin measurement (EFO:0004535)
 PMID:34594039
GWAS1064952_H GCST90092823 Cholesteryl ester levels in HDL 115,082 European ancestry individuals C 0.97542 3E-12 11.523 rs147233090 0.0842679 cholesteryl ester measurement (EFO:0010351)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS1067136_H GCST90018964 Mean corpuscular hemoglobin 350,472 European ancestry individuals, 128,028 East Asian ancestry individuals T NR 4E-15 14.398 rs147233090 0.0608 mean corpuscular hemoglobin (EFO:0004527)
 PMID:34594039
None Available GCST90092822 HDL cholesterol levels 115,082 European ancestry individuals C 0.97542 2E-10 9.699 rs147233090 0.0759128 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS1068473_H GCST90092813 Citrate levels 115,068 European ancestry individuals C 0.975421 1E-23 23 rs147233090 0.131817 citrate measurement (EFO:0010114)
 PMID:35213538
Database Acc Id Source(s)
GWAS Catalog GCST90002328 GWAS Catalog
  GCST90428120 GWAS Catalog

RGD Curation Notes
Note Type Note Reference