GWAS651747_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS651747_H (eosinophil percentage of leukocytes QTL GWAS651747 (human)) Homo sapiens

Symbol: GWAS651747_H
Name: eosinophil percentage of leukocytes QTL GWAS651747 (human)
RGD ID: 407002771
Trait: eosinophil quantity   (VT:0002602)    
Measurement Type: blood eosinophil count to total leukocyte count ratio   (CMO:0000369)    
LOD Score: Not Available
P Value: 2E-307
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3812111,494,996 - 111,494,997RGD_MAPPER_PIPELINEGRCh38
GRCh3712111,932,800 - 111,932,801RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS651747_HHumanblood eosinophil count to total leukocyte count ratio  IAGPrs7137828405850206Based on the EFO term IDGWAS_CATALOGPMID:32888494

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS651747_HHumaneosinophil quantity  IAGPrs7137828405850206Based on the EFO term IDGWAS_CATALOGPMID:32888494

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS651747_HHumaneosinophil percentage of leukocytes  IAGPrs7137828405850206 GWAS_CATALOGPMID:32888494
Experimental Data Annotations     Click to see Annotation Detail View

Vertebrate Trait

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1347160ATXN2ataxin 212111452214111599673Human

Position Markers

Peak: (rs7137828)
Human AssemblyChrPosition (strand)Source
GRCh3812111,494,996 - 111,494,997RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597289880GWAS1385954_Hfree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS1385954 (human)2e-14free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)12111494996111494997Human
1298449UAE2_HUrinary albumin excretion QTL 2 (human)20.005Urinary albumin excretionurine albumin:creatinine ratio (ACR)12102836889128836889Human
597163026GWAS1259100_Hfactor XI measurement, coronary artery disease QTL GWAS1259100 (human)1e-21factor XI measurement, coronary artery disease12111494996111494997Human
406899526GWAS548502_Hsystolic blood pressure QTL GWAS548502 (human)3e-23systolic blood pressuresystolic blood pressure (CMO:0000004)12111494996111494997Human
597594517GWAS1651377_Heosinophil count QTL GWAS1651377 (human)1e-184eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12111494996111494997Human
407002446GWAS651422_Hhematocrit QTL GWAS651422 (human)1e-241hematocrithematocrit (CMO:0000037)12111494996111494997Human
597066139GWAS1162213_Hsystemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis QTL GWAS1162213 (human)2e-09open-angle glaucoma12111494996111494997Human
597038104GWAS1134178_Hparental longevity QTL GWAS1134178 (human)3e-12total life span (VT:0001661)12111494996111494997Human
597054854GWAS1150928_Hsystolic blood pressure QTL GWAS1150928 (human)9e-56systolic blood pressuresystolic blood pressure (CMO:0000004)12111494996111494997Human
597601546GWAS1658406_Hbody mass index QTL GWAS1658406 (human)8e-19body mass indexbody mass index (BMI) (CMO:0000105)12111494996111494997Human
1643264BW195_HBody weight QTL 195 (human)0.0151Body weightBMI1289897665115897665Human
597051661GWAS1147735_Hhematocrit QTL GWAS1147735 (human)3e-243hematocrithematocrit (CMO:0000037)12111494996111494997Human
597159692GWAS1255766_Hlactate measurement QTL GWAS1255766 (human)1e-24blood lactate amount (VT:0010616)blood lactate level (CMO:0001303)12111494996111494997Human
597028616GWAS1124690_Hmean arterial pressure, alcohol drinking QTL GWAS1124690 (human)2e-19blood HDL cholesterol amount (VT:0000184)mean arterial blood pressure (CMO:0000009)12111494996111494997Human
597578557GWAS1635417_Hhematocrit QTL GWAS1635417 (human)1e-47hematocrithematocrit (CMO:0000037)12111494996111494997Human
1643452BW104_HBody weight QTL 104 (human)1.890.005Body fat amountabdominal visceral12102395874128395874Human
1357361BW37_HBody weight QTL 37 (human)4.080.00001Body fat amount12102836889116423339Human
596960945GWAS1080464_Hopen-angle glaucoma QTL GWAS1080464 (human)2e-09open-angle glaucoma12111494996111494997Human
597591227GWAS1648087_Hneutrophil count QTL GWAS1648087 (human)4e-69neutrophil quantity (VT:0000222)blood neutrophil count (CMO:0000030)12111494996111494997Human
406899181GWAS548157_Hdiastolic blood pressure QTL GWAS548157 (human)4e-18diastolic blood pressurediastolic blood pressure (CMO:0000005)12111494996111494997Human
406899189GWAS548165_Hdiastolic blood pressure QTL GWAS548165 (human)7e-15diastolic blood pressurediastolic blood pressure (CMO:0000005)12111494996111494997Human
597038113GWAS1134187_Hparental longevity QTL GWAS1134187 (human)3e-08total life span (VT:0001661)12111494996111494997Human
597585321GWAS1642181_Heosinophil count QTL GWAS1642181 (human)4e-284eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12111494996111494997Human
406899193GWAS548169_Hdiastolic blood pressure QTL GWAS548169 (human)0.000004diastolic blood pressurediastolic blood pressure (CMO:0000005)12111494996111494997Human
597580708GWAS1637568_Hlymphocyte count QTL GWAS1637568 (human)2e-92lymphocyte countblood lymphocyte count (CMO:0000031)12111494996111494997Human
597586725GWAS1643585_Hneutrophil count QTL GWAS1643585 (human)2e-16neutrophil quantity (VT:0000222)blood neutrophil count (CMO:0000030)12111494996111494997Human
597609891GWAS1666751_Hbasophil measurement QTL GWAS1666751 (human)7e-18total cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)12111494996111494997Human
597091368GWAS1187442_Hopen-angle glaucoma QTL GWAS1187442 (human)9e-10open-angle glaucoma12111494996111494997Human
597347365GWAS1443439_Hlean body mass QTL GWAS1443439 (human)1e-18body lean mass (VT:0010483)total body lean mass (CMO:0003950)12111494996111494997Human
597289176GWAS1385250_Htotal cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS1385250 (human)7e-18total cholesterol measurement, high density lipoprotein cholesterol measurement12111494996111494997Human
1559125SPSL2_HSerum P-selectin level QTL 2 (human)2.59Serum P-selectin level1289897665115897665Human
407005568GWAS654544_Hlymphocyte count QTL GWAS654544 (human)3e-496lymphocyte countblood lymphocyte count (CMO:0000031)12111494996111494997Human
597616477GWAS1673337_Herythrocyte count QTL GWAS1673337 (human)2e-23erythrocyte countred blood cell count (CMO:0000025)12111494996111494997Human
597288413GWAS1384487_Hesterified cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS1384487 (human)1e-16esterified cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)12111494996111494997Human
596963549GWAS1083068_Hglucose measurement QTL GWAS1083068 (human)2e-10glucose measurement12111494996111494997Human
597205718GWAS1301792_HGenetic chronic primary adrenal insufficiency QTL GWAS1301792 (human)5e-08Genetic chronic primary adrenal insufficiency12111494996111494997Human
597346772GWAS1442846_Hmonocyte measurement QTL GWAS1442846 (human)3e-16monocyte measurement12111494996111494997Human
597156185GWAS1252259_Hopen-angle glaucoma QTL GWAS1252259 (human)6e-18open-angle glaucoma12111494996111494997Human
597586126GWAS1642986_Heosinophil count QTL GWAS1642986 (human)3e-168eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12111494996111494997Human
407002771GWAS651747_Heosinophil percentage of leukocytes QTL GWAS651747 (human)2e-307eosinophil quantity (VT:0002602)blood eosinophil count to total leukocyte count ratio (CMO:0000369)12111494996111494997Human
597266632GWAS1362706_Heosinophil count QTL GWAS1362706 (human)4e-137eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12111494996111494997Human
597581007GWAS1637867_Hlymphocyte count QTL GWAS1637867 (human)1e-160lymphocyte countblood lymphocyte count (CMO:0000031)12111494996111494997Human
597588431GWAS1645291_Heosinophil count QTL GWAS1645291 (human)5e-211eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12111494996111494997Human
407002768GWAS651744_Hhemoglobin measurement QTL GWAS651744 (human)4e-273hemoglobin measurementhemoglobin measurement (CMO:0000508)12111494996111494997Human
597037380GWAS1133454_Hparental longevity QTL GWAS1133454 (human)3e-14total life span (VT:0001661)12111494996111494997Human
597579853GWAS1636713_Hhematocrit QTL GWAS1636713 (human)4e-24hematocrit12111494996111494997Human
407002774GWAS651750_Hhemoglobin measurement QTL GWAS651750 (human)2e-272hemoglobin measurementhemoglobin measurement (CMO:0000508)12111494996111494997Human
597214924GWAS1310998_Hpappalysin‐1 measurement QTL GWAS1310998 (human)4e-11pappalysin‐1 measurement12111494996111494997Human
597598537GWAS1655397_Hhemoglobin measurement QTL GWAS1655397 (human)1e-12hemoglobin measurementhemoglobin measurement (CMO:0000508)12111494996111494997Human
597594822GWAS1651682_Heosinophil count QTL GWAS1651682 (human)4e-303eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12111494996111494997Human
597594951GWAS1651811_Heosinophil count QTL GWAS1651811 (human)1e-118eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12111494996111494997Human
597179969GWAS1276043_Hlactate measurement QTL GWAS1276043 (human)2e-26blood lactate amount (VT:0010616)blood lactate level (CMO:0001303)12111494996111494997Human
406902170GWAS551146_Hdiastolic blood pressure QTL GWAS551146 (human)1e-63diastolic blood pressurediastolic blood pressure (CMO:0000005)12111494996111494997Human
597180101GWAS1276175_Hinterleukin-23 measurement QTL GWAS1276175 (human)2e-15blood interleukin-23 amount (VT:0008619)12111494996111494997Human
597073736GWAS1169810_Hcoronary artery disease QTL GWAS1169810 (human)4e-27coronary artery disease12111494996111494997Human
1357387BW58_HBody weight QTL 58 (human)2.30.0001Body weightfat free mass after exercise training1289438856115438856Human
597579841GWAS1636701_Heosinophil count QTL GWAS1636701 (human)3e-101eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12111494996111494997Human
597176696GWAS1272770_Hprotein measurement QTL GWAS1272770 (human)6e-15protein measurement12111494996111494997Human
597586943GWAS1643803_Heosinophil count QTL GWAS1643803 (human)9e-227eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12111494996111494997Human
1643258BW205_HBody weight QTL 205 (human)4.080.00001Body fat amountpercent body fat1296630114122630114Human
597166331GWAS1262405_Hopen-angle glaucoma QTL GWAS1262405 (human)5e-18open-angle glaucoma12111494996111494997Human
597164018GWAS1260092_Hcoronary artery disease, factor VII measurement QTL GWAS1260092 (human)3e-21coronary artery disease, factor VII measurement12111494996111494997Human
597024893GWAS1120967_Hallergic disease QTL GWAS1120967 (human)2e-10glucose measurementblood glucose level (CMO:0000046)12111494996111494997Human
597239795GWAS1335869_Heosinophil count QTL GWAS1335869 (human)5e-201eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12111494996111494997Human
597587572GWAS1644432_Heosinophil count QTL GWAS1644432 (human)5e-159eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)12111494996111494997Human
597199348GWAS1295422_Hsystolic blood pressure QTL GWAS1295422 (human)5e-78systolic blood pressuresystolic blood pressure (CMO:0000004)12111494996111494997Human
597597171GWAS1654031_Hlymphocyte count QTL GWAS1654031 (human)9e-216lymphocyte countblood lymphocyte count (CMO:0000031)12111494996111494997Human
597038072GWAS1134146_Hparental longevity QTL GWAS1134146 (human)0.0000002total life span (VT:0001661)12111494996111494997Human
597589230GWAS1646090_Hmonocyte count QTL GWAS1646090 (human)5e-38monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)12111494996111494997Human
597588584GWAS1645444_Hhematocrit QTL GWAS1645444 (human)4e-72hematocrithematocrit (CMO:0000037)12111494996111494997Human
597597414GWAS1654274_Hlymphocyte count QTL GWAS1654274 (human)2e-110lymphocyte countblood lymphocyte count (CMO:0000031)12111494996111494997Human
406894268GWAS543244_Hsystolic blood pressure QTL GWAS543244 (human)0.000003total life span (VT:0001661)systolic blood pressure (CMO:0000004)12111494996111494997Human
597610851GWAS1667711_Hneutrophil count QTL GWAS1667711 (human)3e-73neutrophil quantity (VT:0000222)blood neutrophil count (CMO:0000030)12111494996111494997Human
597199461GWAS1295535_Hdiastolic blood pressure QTL GWAS1295535 (human)7e-182diastolic blood pressurediastolic blood pressure (CMO:0000005)12111494996111494997Human
1358827MULTSCL22_HMultiple sclerosis susceptibility QTL 22 (human)Multiple sclerosis susceptibility1289897665115897665Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS543244_H GCST007095 Systolic blood pressure 80,792 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 7,243 East Asian ancestry individuals, 461 South Asian ancestry individuals C NR 0.000003 5.523 rs7137828 0.266 systolic blood pressure (EFO:0006335)
 PMID:27841878
GWAS1679617_H GCST006169 Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) 12,758 European ancestry heavy drinkers, 1,326 African American or Afro-Caribbean heavy drinkers, 648 Asian ancestry heavy drinkers, 364 Hispanic or Latin American heavy drinkers, 43,947 European ancestry light drinkers, 8,239 African American or Afro-Caribbean light drinkers, 1,141 Asian ancestry light drinkers, 4,448 Hispanic or Latin American light drinkers T 0.51 4E-24 23.398 rs7137828 N/A diastolic blood pressure (EFO:0006336)
 PMID:29912962
GWAS548157_H GCST007098 Diastolic blood pressure 80,792 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 7,243 East Asian ancestry individuals, 461 South Asian ancestry individuals C NR 4E-18 17.398 rs7137828 0.32 diastolic blood pressure (EFO:0006336)
 PMID:27841878
GWAS548165_H GCST007098 Diastolic blood pressure 80,792 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 7,243 East Asian ancestry individuals, 461 South Asian ancestry individuals C NR 7E-15 14.155 rs7137828 0.304 diastolic blood pressure (EFO:0006336)
 PMID:27841878
GWAS548169_H GCST007098 Diastolic blood pressure 80,792 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 7,243 East Asian ancestry individuals, 461 South Asian ancestry individuals C NR 0.000004 5.398 rs7137828 0.613 diastolic blood pressure (EFO:0006336)
 PMID:27841878
GWAS548502_H GCST007099 Systolic blood pressure 295,529 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 2,029 African British individuals, 7,701 East Asian ancestry individuals, 2,735 South Asian ancestry individuals, 1,979 mixed and unknown ancestry individuals C NR 3E-23 22.523 rs7137828 0.389 systolic blood pressure (EFO:0006335)
 PMID:27841878
GWAS1635417_H GCST90479629 hematocrit (mean, inv-norm transformed) 114,988 African American or Afro-Caribbean individuals, 55,841 Hispanic or Latin American individuals, 5,964 East Asian ancestry individuals, 407,852 European ancestry individuals C 0.3906 1E-47 47 rs7137828 0.04163 hematocrit (EFO:0004348)
 PMID:39024449
GWAS551146_H GCST007094 Diastolic blood pressure 295,529 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 2,029 African British individuals, 7,701 East Asian ancestry individuals, 2,735 South Asian ancestry individuals, 1,979 mixed and unknown ancestry individuals C NR 1E-63 63 rs7137828 0.403 diastolic blood pressure (EFO:0006336)
 PMID:27841878
GWAS1636701_H GCST90479606 eosinophil (fraction, minimum, inv-norm transformed) 98,055 African American or Afro-Caribbean individuals, 47,410 Hispanic or Latin American individuals, 4,652 East Asian ancestry individuals, 335,542 European ancestry individuals C 0.3887 3E-101 100.523 rs7137828 0.06236 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1636713_H GCST90479630 hematocrit (minimum, inv-norm transformed) 114,988 African American or Afro-Caribbean individuals, 55,841 Hispanic or Latin American individuals, 5,964 East Asian ancestry individuals, 407,854 European ancestry individuals C 0.3906 4E-24 23.398 rs7137828 0.02735 hematocrit (EFO:0004348)
 PMID:39024449
GWAS1637568_H GCST90479665 lymphocyte (absolute count, minimum, inv-norm transformed) 70,597 African American or Afro-Caribbean individuals, 36,547 Hispanic or Latin American individuals, 3,839 East Asian ancestry individuals, 253,480 European ancestry individuals C 0.3917 2E-92 91.699 rs7137828 0.06473 lymphocyte count (EFO:0004587)
 PMID:39024449
GWAS1637867_H GCST90479664 lymphocyte (absolute count, mean, inv-norm transformed) 70,580 African American or Afro-Caribbean individuals, 36,536 Hispanic or Latin American individuals, 3,839 East Asian ancestry individuals, 253,317 European ancestry individuals C 0.3916 1E-160 160 rs7137828 0.09473 lymphocyte count (EFO:0004587)
 PMID:39024449
GWAS1120967_H GCST005038 Allergic disease (asthma, hay fever or eczema) 180,129 European ancestry cases, 180,709 European ancestry controls T 0.54 2E-10 9.699 rs7137828 1.033 PMID:29083406
GWAS1642181_H GCST90479602 eosinophil (absolute count, mean, inv-norm transformed) 90,448 African American or Afro-Caribbean individuals, 42,397 Hispanic or Latin American individuals, 3,996 East Asian ancestry individuals, 310,757 European ancestry individuals C 0.3897 4E-284 283.398 rs7137828 0.1257 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1642986_H GCST90479604 eosinophil (fraction, maximum, inv-norm transformed) 98,055 African American or Afro-Caribbean individuals, 47,410 Hispanic or Latin American individuals, 4,652 East Asian ancestry individuals, 335,542 European ancestry individuals C 0.3887 3E-168 167.523 rs7137828 0.08901 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1643585_H GCST90475539 neutrophil (fraction, minimum, inv-norm transformed) 38,543 Hispanic or Latin American individuals C 0.3061 2E-16 15.699 rs7137828 0.06346 neutrophil count (EFO:0004833)
 PMID:39024449
GWAS1124690_H GCST006167 Mean arterial pressure x alcohol consumption interaction (2df test) 91,110 European ancestry drinkers and non-drinkers, 21,416 African American or Afro-Caribbean drinkers and non-drinkers, 12,365 Asian ancestry drinkers and non-drinkers, 8,470 Hispanic or Latin American drinkers and non-drinkers T 0.53 2E-19 18.699 rs7137828 N/A mean arterial pressure (EFO:0006340)
alcohol drinking (EFO:0004329)
 PMID:29912962
GWAS1643803_H GCST90479601 eosinophil (absolute count, maximum, inv-norm transformed) 90,403 African American or Afro-Caribbean individuals, 42,380 Hispanic or Latin American individuals, 3,995 East Asian ancestry individuals, 310,588 European ancestry individuals C 0.3897 9E-227 226.046 rs7137828 0.1086 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1644432_H GCST90479603 eosinophil (absolute count, minimum, inv-norm transformed) 90,479 African American or Afro-Caribbean individuals, 42,403 Hispanic or Latin American individuals, 3,997 East Asian ancestry individuals, 310,849 European ancestry individuals C 0.3897 5E-159 158.302 rs7137828 0.07774 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1645291_H GCST90479605 eosinophil (fraction, mean, inv-norm transformed) 98,055 African American or Afro-Caribbean individuals, 47,410 Hispanic or Latin American individuals, 4,652 East Asian ancestry individuals, 335,542 European ancestry individuals C 0.3887 5E-211 210.302 rs7137828 0.1049 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1645444_H GCST90479628 hematocrit (maximum, inv-norm transformed) 114,986 African American or Afro-Caribbean individuals, 55,837 Hispanic or Latin American individuals, 5,964 East Asian ancestry individuals, 407,836 European ancestry individuals C 0.3906 4E-72 71.398 rs7137828 0.0528 hematocrit (EFO:0004348)
 PMID:39024449
GWAS1646090_H GCST90479701 monocyte (absolute count, maximum, inv-norm transformed) 73,039 African American or Afro-Caribbean individuals, 37,339 Hispanic or Latin American individuals, 3,873 East Asian ancestry individuals, 259,269 European ancestry individuals C 0.3907 5E-38 37.302 rs7137828 0.04525 monocyte count (EFO:0005091)
 PMID:39024449
None Available GCST006698 Parental longevity (both parents in top 10%) 7,182 cases, 79,767 controls C NR 0.000003 5.523 rs7137828 N/A parental longevity (EFO:0007796)
 PMID:29227965
GWAS1133454_H GCST006697 Parental longevity (combined parental attained age, Martingale residuals) 389,166 British ancestry individuals C 0.483 3E-14 13.523 rs7137828 0.017 parental longevity (EFO:0007796)
 PMID:29227965
GWAS1134146_H GCST006696 Parental longevity (mother's attained age) 412,937 British ancestry individuals C NR 2E-7 6.699 rs7137828 N/A parental longevity (EFO:0007796)
 PMID:29227965
GWAS1134178_H GCST006701 Parental longevity (father's attained age) 415,311 British ancestry individuals C NR 3E-12 11.523 rs7137828 N/A parental longevity (EFO:0007796)
 PMID:29227965
GWAS1134187_H GCST006702 Parental longevity (combined parental age at death) 208,118 British ancestry individuals C NR 3E-8 7.523 rs7137828 N/A parental longevity (EFO:0007796)
 PMID:29227965
GWAS1648087_H GCST90479715 neutrophil (fraction, minimum, inv-norm transformed) 65,556 African American or Afro-Caribbean individuals, 38,543 Hispanic or Latin American individuals, 3,443 East Asian ancestry individuals, 261,863 European ancestry individuals C 0.3978 4E-69 68.398 rs7137828 0.05803 neutrophil count (EFO:0004833)
 PMID:39024449
GWAS1147735_H GCST90002304 Hematocrit 562,259 European ancestry individuals T 0.51642 3E-243 242.523 rs7137828 0.061464 hematocrit (EFO:0004348)
 PMID:32888493
GWAS1150928_H GCST007087 Systolic blood pressure approximately 422,000 European ancestry individuals ? NR 9E-56 55.046 rs7137828 N/A systolic blood pressure (EFO:0006335)
 PMID:30595370
GWAS1651377_H GCST90475294 eosinophil (absolute count, minimum, inv-norm transformed) 310,849 European ancestry individuals C 0.4945 1E-184 184 rs7137828 0.07982 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1651682_H GCST90475300 eosinophil (fraction, mean, inv-norm transformed) 335,542 European ancestry individuals C 0.4946 4E-303 302.398 rs7137828 0.1084 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1651811_H GCST90475303 eosinophil (fraction, minimum, inv-norm transformed) 335,542 European ancestry individuals C 0.4946 1E-118 118 rs7137828 0.06384 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1654031_H GCST90475426 lymphocyte (absolute count, mean, inv-norm transformed) 253,317 European ancestry individuals C 0.4949 9E-216 215.046 rs7137828 0.1001 lymphocyte count (EFO:0004587)
 PMID:39024449
GWAS1162213_H GCST005528 Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) 2,816 European ancestry cases, 13,056 European ancestry controls C 0.49 2E-9 8.699 rs7137828 1.2 systemic juvenile idiopathic arthritis (EFO:1001999)
polyarticular juvenile idiopathic arthritis, rheumatoid factor negative (EFO:1002020)
oligoarticular juvenile idiopathic arthritis (EFO:1002019)
 PMID:23603761
GWAS1654274_H GCST90475429 lymphocyte (absolute count, minimum, inv-norm transformed) 253,480 European ancestry individuals C 0.4949 2E-110 109.699 rs7137828 0.06769 lymphocyte count (EFO:0004587)
 PMID:39024449
GWAS651422_H GCST90002308 Hematocrit 737,823 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals T 0.533958 1E-241 241 rs7137828 N/A hematocrit (EFO:0004348)
 PMID:32888493
GWAS651744_H GCST90002310 Hemoglobin concentration 563,946 European ancestry individuals T 0.516238 4E-273 272.398 rs7137828 0.064984 hemoglobin measurement (EFO:0004509)
 PMID:32888493
GWAS651747_H GCST90002382 Eosinophil percentage of white cells 408,112 British individuals T 0.51759 2E-307 306.699 rs7137828 0.08334227 eosinophil percentage of leukocytes (EFO:0007991)
 PMID:32888494
GWAS651750_H GCST90002314 Hemoglobin concentration 746,431 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals T 0.533736 2E-272 271.699 rs7137828 N/A hemoglobin measurement (EFO:0004509)
 PMID:32888493
GWAS1655397_H GCST90475369 hemoglobin (maximum, inv-norm transformed) 55,834 Hispanic or Latin American individuals C 0.3081 1E-12 12 rs7137828 0.04404 hemoglobin measurement (EFO:0004509)
 PMID:39024449
GWAS654544_H GCST90002316 Lymphocyte count 524,923 European ancestry individuals T 0.516698 3E-496 495.523 rs7137828 0.090212 lymphocyte count (EFO:0004587)
 PMID:32888493
GWAS1169810_H GCST005195 Coronary artery disease up to 122,733 cases, up to 424,528 controls T 0.5535 4E-27 26.398 rs7137828 0.0643 coronary artery disease (EFO:0001645)
 PMID:29212778
GWAS1658406_H GCST90479523 Body mass index (BMI, minimum, inv-normal transformed) 118,992 African American or Afro-Caribbean individuals, 57,794 Hispanic or Latin American individuals, 6,384 East Asian ancestry individuals, 424,217 European ancestry individuals C 0.3909 8E-19 18.097 rs7137828 0.03021 body mass index (EFO:0004340)
 PMID:39024449
None Available GCST90475536 neutrophil (fraction, mean, inv-norm transformed) 38,542 Hispanic or Latin American individuals C 0.3061 2E-16 15.699 rs7137828 0.06262 neutrophil count (EFO:0004833)
 PMID:39024449
GWAS1187442_H GCST003342 Glaucoma (primary open-angle) 3,853 European ancestry cases, 33,480 European ancestry controls T 0.5 9E-10 9.046 rs7137828 1.17 open-angle glaucoma (EFO:0004190)
 PMID:26752265
GWAS1666751_H GCST90475130 Basophil (absolute count, mean, inv-norm transformed) 158,583 European ancestry individuals C 0.4956 7E-18 17.155 rs7137828 0.03131 basophil measurement (EFO:0803539)
 PMID:39024449
GWAS1667711_H GCST90479714 neutrophil (fraction, mean, inv-norm transformed) 65,554 African American or Afro-Caribbean individuals, 38,542 Hispanic or Latin American individuals, 3,443 East Asian ancestry individuals, 261,847 European ancestry individuals C 0.3978 3E-73 72.523 rs7137828 0.06022 neutrophil count (EFO:0004833)
 PMID:39024449
GWAS1673337_H GCST90480668 red blood cell count (RBC, maximum, inv-norm transformed) 114,767 African American or Afro-Caribbean individuals, 55,750 Hispanic or Latin American individuals, 5,943 East Asian ancestry individuals, 405,357 European ancestry individuals C 0.3904 2E-23 22.699 rs7137828 0.03172 erythrocyte count (EFO:0004305)
 PMID:39024449
GWAS1252259_H GCST90310210 Primary open angle glaucoma (MTAG) at least 29,241 European ancestry cases, at least 350,181 European ancestry controls (MTAG boosted by vertical cup-to-disc ratio and intraocular pressure samples) T NR 6E-18 17.222 rs7137828 0.075553484 open-angle glaucoma (EFO:0004190)
 PMID:37386247
GWAS1255766_H GCST90092882 Lactate levels 114,806 European ancestry individuals C 0.484118 1E-24 24 rs7137828 0.042408 lactate measurement (EFO:0007745)
 PMID:35213538
None Available GCST90092819 Glucose levels 114,870 European ancestry individuals C 0.484109 2E-10 9.699 rs7137828 0.0260567 glucose measurement (EFO:0004468)
 PMID:35213538
GWAS1259100_H GCST90129545 Coronary artery disease or factor XI levels (pleiotropy) 172,122 European, South Asian or East Asian CAD cases, 566,864 European, South Asian or East Asian CAD controls, 16,169 European ancestry individuals with measurements ? NR 1E-21 21 rs7137828 N/A factor XI measurement (EFO:0004694)
coronary artery disease (EFO:0001645)
 PMID:35285134
GWAS1260092_H GCST90129542 Coronary artery disease or factor VII levels (pleiotropy) 172,122 European, South Asian or East Asian CAD cases, 566,864 European, South Asian or East Asian CAD controls, 27,495 European or African American individuals with measurements ? NR 3E-21 20.523 rs7137828 N/A coronary artery disease (EFO:0001645)
factor VII measurement (EFO:0004619)
 PMID:35285134
GWAS1262405_H GCST90310211 Primary open angle glaucoma (multi-trait analysis) at least 29,241 European ancestry cases, at least 350,181 European ancestry controls (MTAG boosted by vertical cup-to-disc ratio and intraocular pressure samples), 6,935 Asian ancestry cases, 39,588 Asian ancestry controls, 3,281 African ancestry cases, 2,791 African ancestry controls T NR 5E-18 17.302 rs7137828 0.0756 open-angle glaucoma (EFO:0004190)
 PMID:37386247
GWAS1682881_H GCST011100 Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) at least 837,415 European ancestry individuals T 0.5167 5E-12 11.302 rs7137828 N/A healthspan (EFO:0009762)
parental longevity (EFO:0007796)
 PMID:32678081
GWAS1272770_H GCST90248030 Interleukin-12 subunit beta levels 10,708 European ancestry individuals T 0.53 6E-15 14.222 rs7137828 0.105 protein measurement (EFO:0004747)
 PMID:34648354
None Available GCST90248636 Neuronal growth regulator 1 levels 10,708 European ancestry individuals T 0.53 3E-12 11.523 rs7137828 0.095 neuronal growth regulator 1 measurement (EFO:0021932)
 PMID:34648354
GWAS1276043_H GCST90269568 Lactate levels (UKB data field 23471) 88,119 European ancestry individuals C 0.485544 2E-26 25.699 rs7137828 0.0489288 lactate measurement (EFO:0007745)
 PMID:36764567
GWAS1276175_H GCST90248061 Interleukin-23 levels 10,708 European ancestry individuals T 0.53 2E-15 14.699 rs7137828 0.106 interleukin-23 measurement (EFO:0020501)
 PMID:34648354
GWAS1295422_H GCST90310294 Systolic blood pressure 1,028,980 European ancestry individuals T NR 5E-78 77.302 rs7137828 0.4524 systolic blood pressure (EFO:0006335)
 PMID:38689001
GWAS1295535_H GCST90310295 Diastolic blood pressure 1,028,980 European ancestry individuals T NR 7E-182 181.155 rs7137828 0.4348 diastolic blood pressure (EFO:0006336)
 PMID:38689001
GWAS1301792_H GCST90011871 Addison's disease 1,223 European ancestry cases, 4,097 European ancestry controls C 0.46 5E-8 7.302 rs7137828 1.3 PMID:33574239
None Available GCST90011770 Glaucoma (primary open-angle) 23,963 European ancestry cases, 306,942 European ancestry controls, 6,935 East Asian ancestry cases, 39,588 East Asian ancestry controls, 3,281 Sub-Saharan African ancestry cases, 2,791 Sub-Saharan African ancestry controls T NR 2E-9 8.699 rs7137828 0.043 open-angle glaucoma (EFO:0004190)
 PMID:33627673
GWAS1310998_H GCST90012036 Pappalysin-1 levels 21,758 European ancestry individuals T 0.53 4E-11 10.398 rs7137828 0.0685 pappalysin‐1 measurement (EFO:0010618)
 PMID:33067605
GWAS1689654_H GCST90129544 Coronary artery disease or von Willebrand factor levels (pleiotropy) 172,122 European, South Asian or East Asian CAD cases, 566,864 European, South Asian or East Asian CAD controls, 46,354 European, African American or Hispanic individuals with measurements ? NR 1E-22 22 rs7137828 N/A coronary artery disease (EFO:0001645)
 PMID:35285134
GWAS1335869_H GCST90056180 Eosinophil counts 234,763 European ancestry individuals C 0.485 5E-201 200.302 rs7137828 N/A eosinophil count (EFO:0004842)
 PMID:34469753
None Available GCST90002367 Red blood cell count 727,624 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals T 0.534191 6E-127 126.222 rs7137828 N/A PMID:32888493
None Available GCST90002363 Red blood cell count 545,203 European ancestry individuals T 0.516713 3E-129 128.523 rs7137828 0.04467 PMID:32888493
None Available GCST90016667 Spleen volume 32,860 European ancestry individuals ? NR 3E-83 82.523 rs7137828 0.133 PMID:34128465
None Available GCST90027079 Albumin levels 148,248 British ancestry men T 0.52 3E-10 9.523 rs7137828 0.08 PMID:34321204
GWAS1362706_H GCST90134621 Eosinophil counts 365,954 British ancestry individuals C 0.464 4E-137 136.398 rs7137828 0.092 eosinophil count (EFO:0004842)
 PMID:35935937
None Available GCST90476451 white blood cell count (WBC, maximum, inv-norm transformed) 380,686 European ancestry individuals C 0.4943 7E-102 101.155 rs7137828 0.05708 PMID:39024449
None Available GCST90476454 white blood cell count (WBC, mean, inv-norm transformed) 381,099 European ancestry individuals C 0.4942 2E-179 178.699 rs7137828 0.07905 PMID:39024449
None Available GCST90476457 white blood cell count (WBC, minimum, inv-norm transformed) 381,267 European ancestry individuals C 0.4943 1E-143 143 rs7137828 0.06985 PMID:39024449
None Available GCST90302130 Free cholesterol in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals T 0.547 2E-19 18.699 rs7137828 0.0369 free cholesterol in very large HDL measurement (EFO:0022273)
 PMID:38448586
GWAS1384487_H GCST90302128 Cholesterol esters in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals T 0.5468 1E-16 16 rs7137828 0.0338 esterified cholesterol measurement (EFO:0008589)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS1385250_H GCST90302126 Total cholesterol levels in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals T 0.5469 7E-18 17.155 rs7137828 0.0351 total cholesterol measurement (EFO:0004574)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS1385954_H GCST90302131 Free cholesterol to total lipids ratio in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals T 0.5458 2E-14 13.699 rs7137828 0.0312 free cholesterol:total lipids ratio (EFO:0020945)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS1696155_H GCST90399470 Glaucoma (primary open-angle) 21,839 European, African, Central/South Asian, East Asian or Hispanic cases, 1,237,201 European, African, Central/South Asian, East Asian or Hispanic controls, 15,229 European ancestry cases, 177,473 European ancestry controls, 9,257 African ancestry cases, 17,038 African ancestry controls ? NR 3E-10 9.523 rs7137828 0.065545 open-angle glaucoma (EFO:0004190)
 PMID:38382466
GWAS1442846_H GCST90281240 Monocyte side scatter 39,608 European ancestry individuals T 0.5172 3E-16 15.523 rs7137828 0.0563919 monocyte measurement (EFO:0803547)
 PMID:37596262
GWAS1443439_H GCST90428120 Whole body fat free mass (UKB data field 23101) 337,739 European ancestry individuals T NR 1E-18 18 rs7137828 0.0116159 lean body mass (EFO:0004995)
 PMID:38538606
None Available GCST90480724 white blood cell count (WBC, mean, inv-norm transformed) 108,896 African American or Afro-Caribbean individuals, 49,978 Hispanic or Latin American individuals, 5,839 East Asian ancestry individuals, 381,099 European ancestry individuals C 0.3903 9E-100 99.046 rs7137828 0.07237 PMID:39024449
None Available GCST90479505 Albumin (minimum, inv-norm transformed) 110,337 African American or Afro-Caribbean individuals, 53,293 Hispanic or Latin American individuals, 5,708 East Asian ancestry individuals, 372,982 European ancestry individuals C 0.3874 2E-11 10.699 rs7137828 0.01736 PMID:39024449
None Available GCST90480723 white blood cell count (WBC, maximum, inv-norm transformed) 108,774 African American or Afro-Caribbean individuals, 49,939 Hispanic or Latin American individuals, 5,836 East Asian ancestry individuals, 380,686 European ancestry individuals C 0.3904 9E-70 69.046 rs7137828 0.05502 PMID:39024449
Database Acc Id Source(s)
GWAS Catalog GCST90002382 GWAS Catalog

RGD Curation Notes
Note Type Note Reference