GWAS593310_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS593310_H (thyroid function QTL GWAS593310 (human)) Homo sapiens

Symbol: GWAS593310_H
Name: thyroid function QTL GWAS593310 (human)
RGD ID: 406944334
Trait: thyroid function
LOD Score: Not Available
P Value: 3.0E-27
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38577,239,986 - 77,239,987RGD_MAPPER_PIPELINEGRCh38
GRCh37576,535,811 - 76,535,812RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS593310_HHumanthyroid function  IAGPrs2046045405850206 GWAS_CATALOGPMID:22494929
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1348334PDE8Bphosphodiesterase 8B57708671577428256Human

Position Markers

Peak: (rs2046045)
Human AssemblyChrPosition (strand)Source
GRCh38577,239,986 - 77,239,987RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406987114GWAS636090_Hthyroid stimulating hormone measurement QTL GWAS636090 (human)7e-781thyroid stimulating hormone measurementblood thyroid stimulating hormone level (CMO:0001247)57723998677239987Human
406952509GWAS601485_Hthyroid stimulating hormone measurement QTL GWAS601485 (human)4e-33thyroid stimulating hormone measurementblood thyroid stimulating hormone level (CMO:0001247)57723998677239987Human
406948844GWAS597820_Hhyperthyroidism QTL GWAS597820 (human)4e-22hyperthyroidism57723998677239987Human
406944334GWAS593310_Hthyroid function QTL GWAS593310 (human)3e-27thyroid function57723998677239987Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
None Available GCST008165 Thyroid stimulating hormone levels 2,287 European ancestry whole-genome sequenced individuals, 14,048 European ancestry individuals G 0.414 4E-33 32.398 rs2046045 0.142 thyroid stimulating hormone measurement (EFO:0004748)
 PMID:25743335
None Available GCST006897 Hyperthyroidism 1,840 European ancestry cases, 49,983 European ancestry controls T 0.6 4E-22 21.398 rs2046045 0.329 hyperthyroidism (EFO:0009189)
 PMID:30367059
None Available GCST001487 Thyroid function 3,736 European ancestry individuals T 0.618 3E-27 26.523 rs2046045 0.115 thyroid function (EFO:0004296)
 PMID:22494929
None Available GCST90435200 Overt hyperthyroidism in pregnancy 1,648 Chinese ancestry cases, 68,140 Chinese ancestry controls T 0.160327 3E-8 7.523 rs2046045 1.41 hyperthyroidism (EFO:0009189)
 PMID:39266554
None Available GCST90296333 Thyroid stimulating hormone levels 247,107 European ancestry individuals T 0.6076 7E-781 780.155 rs2046045 0.1539 thyroid stimulating hormone measurement (EFO:0004748)
 PMID:37872160
Database Acc Id Source(s)
GWAS Catalog GCST001487 GWAS Catalog

RGD Curation Notes
Note Type Note Reference