GWAS555230_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS555230_H (folic acid measurement QTL GWAS555230 (human)) Homo sapiens

Symbol: GWAS555230_H
Name: folic acid measurement QTL GWAS555230 (human)
RGD ID: 406906254
Trait: folic acid measurement
LOD Score: Not Available
P Value: 1.0E-52
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38111,796,321 - 11,796,322RGD_MAPPER_PIPELINEGRCh38
GRCh37111,856,378 - 11,856,379RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS555230_HHumanfolic acid measurement  IAGPrs1801133405850206 GWAS_CATALOGPMID:23754956
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
733483MTHFRmethylenetetrahydrofolate reductase11178572311805964Human

Position Markers

Peak: (rs1801133)
Human AssemblyChrPosition (strand)Source
GRCh38111,796,321 - 11,796,322RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
406991175GWAS640151_Hhomocysteine measurement QTL GWAS640151 (human)1e-19homocysteine measurement11179632111796322Human
407170626GWAS819602_Hage at menopause QTL GWAS819602 (human)3e-08serine measurementblood amino acid measurement (CMO:0003730)11179632111796322Human
407023173GWAS672149_Hhomocysteine measurement QTL GWAS672149 (human)4e-104homocysteine measurement11179632111796322Human
406946950GWAS595926_Hhomocysteine measurement QTL GWAS595926 (human)8e-35homocysteine measurement11179632111796322Human
406991173GWAS640149_Hfolic acid measurement QTL GWAS640149 (human)3e-11folic acid measurement11179632111796322Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
406906254GWAS555230_Hfolic acid measurement QTL GWAS555230 (human)1e-52folic acid measurement11179632111796322Human
407086867GWAS735843_HX-24337 measurement QTL GWAS735843 (human)7e-32X-24337 measurement11179632111796322Human
407342295GWAS991271_HBMI-adjusted hip circumference QTL GWAS991271 (human)8e-09BMI-adjusted hip circumferencehip circumference (CMO:0000014)11179632111796322Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
406917333GWAS566309_Hhigh altitude adaptation QTL GWAS566309 (human)6e-09high altitude adaptation11179632111796322Human
407406748GWAS1055724_Hobsolete_red blood cell distribution width QTL GWAS1055724 (human)1e-23obsolete_red blood cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)11179632111796322Human
407339025GWAS988001_Hglycine measurement QTL GWAS988001 (human)2e-08cortical thicknessblood amino acid measurement (CMO:0003730)11179632111796322Human
406994517GWAS643493_Hhomocysteine measurement QTL GWAS643493 (human)2e-11homocysteine measurement11179632111796322Human
407184338GWAS833314_Hfolic acid measurement QTL GWAS833314 (human)6e-14folic acid measurement11179632111796322Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
407176218GWAS825194_Hmultiple sclerosis QTL GWAS825194 (human)2e-15multiple sclerosis11179632111796322Human
407215973GWAS864949_Hschizophrenia QTL GWAS864949 (human)4e-15schizophrenia11179632111796322Human
407238308GWAS887284_Hhomocysteine measurement QTL GWAS887284 (human)1e-120homocysteine measurement11179632111796322Human
407184621GWAS833597_Hhomocysteine measurement QTL GWAS833597 (human)6e-69homocysteine measurement11179632111796322Human
407361455GWAS1010431_Hhomocysteine measurement QTL GWAS1010431 (human)2e-21homocysteine measurement11179632111796322Human
407318828GWAS967804_HX-24337 measurement QTL GWAS967804 (human)9e-43X-24337 measurement11179632111796322Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human
407035187GWAS684163_Hmean reticulocyte volume QTL GWAS684163 (human)1e-12reticulocyte morphology trait (VT:0002424)mean corpuscular volume (CMO:0000038)11179632111796322Human
406933491GWAS582467_Hfolic acid measurement QTL GWAS582467 (human)4e-19folic acid measurement11179632111796322Human
407175615GWAS824591_Hage at menopause QTL GWAS824591 (human)9e-08age at menopause11179632111796322Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS555230_H GCST90277443 Serum folate levels 21,708 Danish, Icelandic ancestry individuals G 0.668 1E-52 52 rs1801133 N/A folic acid measurement (EFO:0005111)
 PMID:23754956
GWAS566309_H GCST006054 High altitude adaptation 3,008 Tibetan (founder/genetic isolate) individuals and 7,287 East Asian individuals A 0.333 6E-9 8.222 rs1801133 N/A high altitude adaptation (EFO:0009105)
 PMID:28373541
GWAS582467_H GCST006137 Serum folate levels 1,999 Han Chinese ancestry individuals ? NR 4E-19 18.398 rs1801133 N/A folic acid measurement (EFO:0005111)
 PMID:29953918
GWAS595926_H GCST000367 Homocysteine levels 13,974 European ancestry females A 0.33 8E-35 34.097 rs1801133 0.05 homocysteine measurement (EFO:0004578)
 PMID:20031578
GWAS640149_H GCST007579 Serum folate levels 2,232 Irish ancestry individuals ? NR 3E-11 10.523 rs1801133 0.04932 folic acid measurement (EFO:0005111)
 PMID:30339177
GWAS640151_H GCST007578 Plasma homocysteine levels 2,232 Irish ancestry individuals ? NR 1E-19 19 rs1801133 0.03087 homocysteine measurement (EFO:0004578)
 PMID:30339177
GWAS643493_H GCST009171 Homocysteine levels 1,208 European ancestry individuals ? NR 2E-11 10.699 rs1801133 N/A homocysteine measurement (EFO:0004578)
 PMID:23696881
GWAS672149_H GCST002087 Homocysteine levels 44,147 European ancestry individuals A 0.34 4E-104 103.398 rs1801133 0.1583 homocysteine measurement (EFO:0004578)
 PMID:23824729
GWAS684163_H GCST90002396 Mean reticulocyte volume 408,112 British individuals A 0.33642 1E-12 12 rs1801133 0.018249054 mean reticulocyte volume (EFO:0010701)
 PMID:32888494
GWAS735843_H GCST90200629 X-24337 levels 8,088 European ancestry individuals A 0.34098 7E-32 31.155 rs1801133 0.190416 X-24337 measurement (EFO:0800875)
 PMID:36635386
GWAS819602_H GCST90026597 Age at menopause 181,219 European ancestry individuals A 0.34 3E-8 7.523 rs1801133 0.08 age at menopause (EFO:0004704)
 PMID:34050765
GWAS824591_H GCST90026598 Age at menopause 181,219 European ancestry individuals, 43,861 East Asian ancestry individuals A 0.34 9E-8 7.046 rs1801133 0.07 age at menopause (EFO:0004704)
 PMID:34050765
GWAS825194_H GCST009597 Multiple sclerosis 14,802 European and unknown ancestry cases, 26,703 European and unknown ancestry controls G NR 2E-15 14.699 rs1801133 1.107052 PMID:31604244
GWAS833314_H GCST90319528 Vitamin B9 levels 9,947 Han Chinese ancestry individuals, 294 individuals A NR 6E-14 13.222 rs1801133 0.12 folic acid measurement (EFO:0005111)
 PMID:37479695
GWAS833597_H GCST90319530 Homocysteine levels 9,947 Han Chinese ancestry individuals, 294 individuals A NR 6E-69 68.222 rs1801133 0.26 homocysteine measurement (EFO:0004578)
 PMID:37479695
None Available GCST90100220 Estimated glomerular filtration rate (creatinine) 1,205,871 European ancestry individuals, 168,300 East Asian ancestry individuals, 63,553 African ancestry individuals, 23,509 Hispanic or Latin American individuals, 22,103 African American individuals, 21,791 Central Asian or South Asian ancestry individuals, 1,502 Middle Eastern ancestry individuals, 939 other admixed ancestry individuals, 602 Native American ancestry individuals, 150 Asian ancestry individuals, 339 individuals A 0.3333 3E-8 7.523 rs1801133 5.572 glomerular filtration rate (EFO:0005208)
 PMID:35710981
None Available GCST90103799 Leprosy 2,118 Chinese ancestry cases, 2,822 Chinese ancestry controls A NR 3E-8 7.523 rs1801133 0.81 leprosy (EFO:0001054)
 PMID:35512355
GWAS864949_H GCST012368 Early-onset schizophrenia 1,256 Han Chinese ancestry cases, 2,661 Han Chinese ancestry controls A 0.45 4E-15 14.398 rs1801133 1.346 PMID:33907183
GWAS887284_H GCST90090974 Homocysteine levels 5,175 Han Chinese ancestry individuals T 0.58 1E-120 120 rs1801133 0.45 homocysteine measurement (EFO:0004578)
 PMID:34707639
None Available GCST90134364 Serine levels 5,505 European ancestry individuals ? NR 3E-8 7.523 rs1801133 0.113 serine measurement (EFO:0009774)
 PMID:35888728
None Available GCST007074 Red cell distribution width approximately 445,000 European ancestry individuals ? NR 1E-23 23 rs1801133 N/A Red cell distribution width (EFO:0009188)
 PMID:30595370
GWAS967804_H GCST90140587 X-24337 levels 6,136 Finnish ancestry individuals A NR 9E-43 42.046 rs1801133 0.3 X-24337 measurement (EFO:0800875)
 PMID:35347128
GWAS988001_H GCST90092820 Glycine levels 114,978 European ancestry individuals G 0.662601 2E-8 7.699 rs1801133 0.0231927 glycine measurement (EFO:0009767)
 PMID:35213538
GWAS991271_H GCST90020026 Hip index 219,872 British ancestry women A NR 8E-9 8.097 rs1801133 0.0177964 BMI-adjusted hip circumference (EFO:0008039)
 PMID:34021172
None Available GCST90095131 Vertex-wise cortical thickness 33,748 European ancestry individuals A 0.36 2E-8 7.699 rs1801133 5.59 cortical thickness (EFO:0004840)
 PMID:34910505
GWAS1010431_H GCST90429184 Homocysteine levels 1,804 Korean ancestry individuals A NR 2E-21 20.699 rs1801133 0.296488 homocysteine measurement (EFO:0004578)
 PMID:38626723
None Available GCST90335164 Diastolic blood pressure (BMI unadjusted) 100,453 Chinese Han ancestry individuals A 0.56 2E-12 11.699 rs1801133 0.3986 diastolic blood pressure (EFO:0006336)
 PMID:39048560
None Available GCST90335165 Diastolic blood pressure (BMI adjusted) 100,453 Chinese Han ancestry individuals A 0.56 4E-11 10.398 rs1801133 0.3621 diastolic blood pressure (EFO:0006336)
 PMID:39048560
None Available GCST90448609 Folate levels 38,000 South Asian ancestry individuals A NR 8E-38 37.097 rs1801133 0.172 folic acid measurement (EFO:0005111)
 PMID:39414775
Database Acc Id Source(s)
GWAS Catalog GCST90277443 GWAS Catalog

RGD Curation Notes
Note Type Note Reference