GWAS540602_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS540602_H (high density lipoprotein cholesterol measurement QTL GWAS540602 (human)) Homo sapiens

Symbol: GWAS540602_H
Name: high density lipoprotein cholesterol measurement QTL GWAS540602 (human)
RGD ID: 406891626
Trait: high density lipoprotein cholesterol measurement
Measurement Type: blood high density lipoprotein cholesterol level   (CMO:0000052)    
LOD Score: Not Available
P Value: 3.0E-7
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38221,014,672 - 21,014,673RGD_MAPPER_PIPELINEGRCh38
GRCh37221,237,544 - 21,237,545RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS540602_HHumanblood high density lipoprotein cholesterol level  IAGPrs673548405850206Based on the EFO term IDGWAS_CATALOGPMID:29507422

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS540602_HHumanhigh density lipoprotein cholesterol measurement  IAGPrs673548405850206 GWAS_CATALOGPMID:29507422
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
735787APOBapolipoprotein B22100142921044073Human

Position Markers

Peak: (rs673548)
Human AssemblyChrPosition (strand)Source
GRCh38221,014,672 - 21,014,673RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407115588GWAS764564_Hphospholipids in medium HDL measurement QTL GWAS764564 (human)7e-14phospholipids in medium HDL measurement 22101467221014673Human
407282246GWAS931222_Hphospholipids:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS931222 (human)2e-33phospholipids:total lipids ratio, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
406950594GWAS599570_Hlipid measurement QTL GWAS599570 (human)4e-10lipid measurementblood lipid measurement (CMO:0000050)22101467221014673Human
407086151GWAS735127_Hphospholipids:total lipids ratio QTL GWAS735127 (human)2e-28phospholipids:total lipids ratio22101467221014673Human
407240909GWAS889885_Hhigh density lipoprotein cholesterol measurement QTL GWAS889885 (human)5e-26high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407130825GWAS779801_Hesterified cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS779801 (human)2e-24esterified cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407191243GWAS840219_Hproprotein convertase subtilisin/kexin type 9 measurement QTL GWAS840219 (human)2e-12proprotein convertase subtilisin/kexin type 9 measurement22101467221014673Human
407138517GWAS787493_Hphospholipids in very large HDL measurement QTL GWAS787493 (human)1e-30phospholipids in very large HDL measurement 22101467221014673Human
407323734GWAS972710_Htriglyceride measurement QTL GWAS972710 (human)1e-173triglyceride measurementblood triglyceride level (CMO:0000118)22101467221014673Human
407296723GWAS945699_Hfatty acid measurement QTL GWAS945699 (human)1e-38fatty acid measurement22101467221014673Human
407117906GWAS766882_Hhigh density lipoprotein cholesterol measurement QTL GWAS766882 (human)4e-27high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407051092GWAS700068_Hsexual dimorphism measurement QTL GWAS700068 (human)3e-16sexual dimorphism measurement22101467221014673Human
407032665GWAS681641_Hphospholipids in very large HDL measurement QTL GWAS681641 (human)3e-13phospholipids in very large HDL measurement 22101467221014673Human
407130713GWAS779689_Hfree cholesterol in very large HDL measurement QTL GWAS779689 (human)2e-23free cholesterol in very large HDL measurement 22101467221014673Human
407080546GWAS729522_Hmetabolic syndrome QTL GWAS729522 (human)2e-32metabolic syndrome22101467221014673Human
407090273GWAS739249_Hfree cholesterol in medium HDL measurement QTL GWAS739249 (human)2e-16free cholesterol in medium HDL measurement 22101467221014673Human
407093857GWAS742833_Htriglycerides to total lipids in large HDL percentage QTL GWAS742833 (human)2e-54triglycerides to total lipids in large HDL percentage 22101467221014673Human
407111270GWAS760246_Hhigh density lipoprotein cholesterol measurement QTL GWAS760246 (human)3e-12phosphatidylethanolamine measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
406928483GWAS577459_Hserum metabolite measurement QTL GWAS577459 (human)2e-08triglyceride measurementblood triglyceride level (CMO:0000118)22101467221014673Human
407042017GWAS690993_Hfree cholesterol in large HDL measurement QTL GWAS690993 (human)4e-35free cholesterol in large HDL measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407031526GWAS680502_Hfree cholesterol in very large HDL measurement QTL GWAS680502 (human)9e-21free cholesterol in very large HDL measurement 22101467221014673Human
406935399GWAS584375_Hserum metabolite measurement QTL GWAS584375 (human)9e-12serum metabolite measurement22101467221014673Human
406891625GWAS540601_Hhigh density lipoprotein cholesterol measurement QTL GWAS540601 (human)8e-51high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407242095GWAS891071_Hapolipoprotein B measurement QTL GWAS891071 (human)6e-219apolipoprotein B measurementblood apoliprotein B level (CMO:0000522)22101467221014673Human
406891626GWAS540602_Hhigh density lipoprotein cholesterol measurement QTL GWAS540602 (human)0.0000003high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
406891627GWAS540603_Hhigh density lipoprotein cholesterol measurement QTL GWAS540603 (human)1e-56high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
406991086GWAS640062_Htriglyceride measurement QTL GWAS640062 (human)0.0000004triglyceride measurementblood triglyceride level (CMO:0000118)22101467221014673Human
407058798GWAS707774_Hserum metabolite measurement QTL GWAS707774 (human)6e-10serum metabolite measurement22101467221014673Human
406986092GWAS635068_Hhigh density lipoprotein cholesterol measurement QTL GWAS635068 (human)3e-09high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407034605GWAS683581_Htriacylglycerol 54:4 measurement QTL GWAS683581 (human)4e-08blood triglyceride amount (VT:0002644)22101467221014673Human
407103724GWAS752700_Hfree cholesterol to total lipids in medium HDL percentage QTL GWAS752700 (human)4e-39free cholesterol to total lipids in medium HDL percentage 22101467221014673Human
407290102GWAS939078_Hfatty acid measurement QTL GWAS939078 (human)2e-18fatty acid measurement22101467221014673Human
406905458GWAS554434_Hlow density lipoprotein cholesterol measurement QTL GWAS554434 (human)3e-20low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)22101467221014673Human
406905459GWAS554435_Hlow density lipoprotein cholesterol measurement QTL GWAS554435 (human)1e-13coronary artery calcificationblood low density lipoprotein cholesterol level (CMO:0000053)22101467221014673Human
407136766GWAS785742_Htotal lipids in very large HDL measurement QTL GWAS785742 (human)2e-27total lipids in very large HDL measurement 22101467221014673Human
407091832GWAS740808_Htriglyceride measurement QTL GWAS740808 (human)0.000002triglyceride measurementblood triglyceride level (CMO:0000118)22101467221014673Human
407266555GWAS915531_Htotal cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS915531 (human)5e-38total cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407095932GWAS744908_Hcholesteryl esters to total lipids in very small VLDL percentage QTL GWAS744908 (human)3e-54cholesteryl esters to total lipids in very small VLDL percentage 22101467221014673Human
407062279GWAS711255_Htotal cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS711255 (human)2e-44total cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407115392GWAS764368_Htotal lipids in medium HDL measurement QTL GWAS764368 (human)5e-14total lipids in medium HDL measurement 22101467221014673Human
407084164GWAS733140_Hfree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS733140 (human)2e-15free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407041548GWAS690524_Htriacylglycerol 52:3 measurement QTL GWAS690524 (human)4e-09blood triglyceride amount (VT:0002644)22101467221014673Human
407121675GWAS770651_Htotal lipids in large HDL QTL GWAS770651 (human)3e-36total lipids in large HDL22101467221014673Human
407067666GWAS716642_Hchylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement QTL GWAS716642 (human)1e-27chylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurementblood very low density lipoprotein cholesterol level (CMO:0000648)22101467221014673Human
406949522GWAS598498_Hlipid measurement QTL GWAS598498 (human)5e-42lipid measurementblood lipid measurement (CMO:0000050)22101467221014673Human
407032214GWAS681190_Hlipoprotein measurement QTL GWAS681190 (human)5e-13lipoprotein measurementblood lipoprotein measurement (CMO:0002690)22101467221014673Human
406957335GWAS606311_Hsodium-coupled monocarboxylate transporter 1 measurement QTL GWAS606311 (human)9e-56sodium-coupled monocarboxylate transporter 1 measurement22101467221014673Human
407030037GWAS679013_Hhigh density lipoprotein particle size measurement QTL GWAS679013 (human)1e-25high density lipoprotein particle size measurementblood high density lipoprotein particle diameter (CMO:0002692)22101467221014673Human
407096084GWAS745060_Hcholesteryl ester measurement QTL GWAS745060 (human)7e-34blood lipid amount (VT:0003949)22101467221014673Human
407168030GWAS817006_Hcholesteryl ester measurement, high density lipoprotein cholesterol measurement QTL GWAS817006 (human)1e-37blood lipid amount (VT:0003949)blood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407062808GWAS711784_Htotal cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS711784 (human)7e-41total cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407293083GWAS942059_Hhigh density lipoprotein cholesterol measurement QTL GWAS942059 (human)2e-119high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407069341GWAS718317_Htotal cholesterol measurement QTL GWAS718317 (human)1e-11total cholesterol measurementblood total cholesterol level (CMO:0000051)22101467221014673Human
407283864GWAS932840_Htotal cholesterol measurement QTL GWAS932840 (human)1e-55total cholesterol measurementblood total cholesterol level (CMO:0000051)22101467221014673Human
407069340GWAS718316_Htotal cholesterol measurement QTL GWAS718316 (human)1e-17total cholesterol measurementblood total cholesterol level (CMO:0000051)22101467221014673Human
407100444GWAS749420_Hcholesterol to total lipids in medium HDL percentage QTL GWAS749420 (human)4e-55cholesterol to total lipids in medium HDL percentage 22101467221014673Human
407333400GWAS982376_Hlow density lipoprotein cholesterol measurement QTL GWAS982376 (human)5e-112low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)22101467221014673Human
407249319GWAS898295_Hapolipoprotein A 1 measurement QTL GWAS898295 (human)3e-117apolipoprotein A 1 measurementblood apolipoprotein AI level (CMO:0000520)22101467221014673Human
407166502GWAS815478_Hhigh density lipoprotein cholesterol measurement QTL GWAS815478 (human)2e-29high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
406913577GWAS562553_Htriglyceride measurement QTL GWAS562553 (human)4e-66triglyceride measurementblood triglyceride level (CMO:0000118)22101467221014673Human
407096618GWAS745594_Hcholesterol in large HDL measurement QTL GWAS745594 (human)2e-34cholesterol in large HDL measurement 22101467221014673Human
406913579GWAS562555_Htriglyceride measurement QTL GWAS562555 (human)1e-69triglyceride measurementblood triglyceride level (CMO:0000118)22101467221014673Human
407132462GWAS781438_Hhigh density lipoprotein cholesterol measurement QTL GWAS781438 (human)5e-27high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407332653GWAS981629_Hvery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio QTL GWAS981629 (human)2e-64very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratioblood very low density lipoprotein cholesterol level (CMO:0000648)22101467221014673Human
406913578GWAS562554_Htriglyceride measurement QTL GWAS562554 (human)0.0000008triglyceride measurementblood triglyceride level (CMO:0000118)22101467221014673Human
407052206GWAS701182_Htotal cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS701182 (human)8e-25total cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407059122GWAS708098_Hserum metabolite measurement QTL GWAS708098 (human)1e-12serum metabolite measurement22101467221014673Human
407282743GWAS931719_Hfree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS931719 (human)4e-44free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407051579GWAS700555_Hmetabolic syndrome QTL GWAS700555 (human)1e-10proprotein convertase subtilisin/kexin type 9 measurement22101467221014673Human
407279419GWAS928395_Hcholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS928395 (human)4e-67cholesterol:total lipids ratio, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407091005GWAS739981_Htotal cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS739981 (human)1e-21total cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human
407083197GWAS732173_Hesterified cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS732173 (human)1e-22esterified cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)22101467221014673Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS540601_H GCST007140 High density lipoprotein cholesterol levels 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals G 0.785 8E-51 50.097 rs673548 0.069 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:29507422
GWAS540602_H GCST007140 High density lipoprotein cholesterol levels 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals G 0.754 3E-7 6.523 rs673548 0.074 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:29507422
GWAS540603_H GCST007140 High density lipoprotein cholesterol levels 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals G NR 1E-56 56 rs673548 0.065 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:29507422
GWAS554434_H GCST007141 Low density lipoprotein cholesterol levels 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals G 0.785 3E-20 19.523 rs673548 0.053 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:29507422
GWAS554435_H GCST007141 Low density lipoprotein cholesterol levels 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals G NR 1E-13 13 rs673548 0.037 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:29507422
GWAS562553_H GCST007142 Triglycerides 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals G 0.785 4E-66 65.398 rs673548 0.086 triglyceride measurement (EFO:0004530)
 PMID:29507422
GWAS562554_H GCST007142 Triglycerides 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals G 0.754 8E-7 6.097 rs673548 0.078 triglyceride measurement (EFO:0004530)
 PMID:29507422
GWAS562555_H GCST007142 Triglycerides 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals G NR 1E-69 69 rs673548 0.079 triglyceride measurement (EFO:0004530)
 PMID:29507422
GWAS577459_H GCST009240 Serum metabolite levels (CMS) 6,263 Finnish ancestry men ? NR 2E-8 7.699 rs673548 0.05945241 serum metabolite measurement (EFO:0005653)
 PMID:31636271
GWAS584375_H GCST009240 Serum metabolite levels (CMS) 6,263 Finnish ancestry men ? NR 9E-12 11.046 rs673548 0.068695925 serum metabolite measurement (EFO:0005653)
 PMID:31636271
GWAS598498_H GCST000533 Lipid metabolism phenotypes Up to 17,296 European ancestry female individuals ? NR 5E-42 41.302 rs673548 6.624 lipid measurement (EFO:0004529)
 PMID:19936222
GWAS599570_H GCST000533 Lipid metabolism phenotypes Up to 17,296 European ancestry female individuals ? NR 4E-10 9.398 rs673548 0.041 lipid measurement (EFO:0004529)
 PMID:19936222
GWAS606311_H GCST90249453 Sodium-coupled monocarboxylate transporter 1 levels 10,708 European ancestry individuals A 0.21 9E-56 55.046 rs673548 0.256 sodium-coupled monocarboxylate transporter 1 measurement (EFO:0802076)
 PMID:34648354
GWAS635068_H GCST008035 High density lipoprotein cholesterol levels 10,085 African American individuals, 17,751 Hispanic/Latino individuals, 2,378 Asian ancestry individuals, 1,912 Native Hawaiian ancestry individuals, 604 Native American ancestry individuals, 333 individuals ? NR 3E-9 8.523 rs673548 0.7666658 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:31217584
GWAS640062_H GCST008046 Triglyceride levels 9,980 African American individuals, 17,856 Hispanic/Latino individuals, 2,381 Asian ancestry individuals, 1,915 Native Hawaiian ancestry individuals, 604 Native American ancestry individuals, 360 individuals ? NR 4E-7 6.398 rs673548 0.02367532 triglyceride measurement (EFO:0004530)
 PMID:31217584
None Available GCST000292 Metabolic traits 4,763 Northern Finnish founder individuals A 0.27 2E-8 7.699 rs673548 0.08 triglyceride measurement (EFO:0004530)
 PMID:19060910
GWAS679013_H GCST90269530 Average diameter for HDL particles (UKB data field 23433) 88,329 European ancestry individuals A 0.205544 1E-25 25 rs673548 0.0549644 high density lipoprotein particle size measurement (EFO:0008592)
 PMID:36764567
GWAS680502_H GCST90269653 Free cholesterol in very large HDL (UKB data field 23556) 88,329 European ancestry individuals A 0.205544 9E-21 20.046 rs673548 0.0512688 free cholesterol in very large HDL measurement (EFO:0022273)
 PMID:36764567
GWAS681190_H GCST90269524 Total concentration of lipoprotein particles (UKB data field 23427) 88,329 European ancestry individuals A 0.205544 5E-13 12.302 rs673548 0.0397506 lipoprotein measurement (EFO:0004732)
 PMID:36764567
GWAS681641_H GCST90269650 Phospholipids in very large HDL (UKB data field 23553) 88,329 European ancestry individuals A 0.205544 3E-13 12.523 rs673548 0.0388317 phospholipids in very large HDL measurement (EFO:0022298)
 PMID:36764567
GWAS683581_H GCST90277405 Triacylglycerol (54:4) levels 7,165 Finnish ancestry individuals A 0.272537 4E-8 7.398 rs673548 0.102084 triacylglycerol 54:4 measurement (EFO:0010422)
 PMID:37907536
None Available GCST001639 Metabolite levels 6,608 European ancestry individuals ? 0.27 1E-13 13 rs673548 N/A coronary artery calcification (EFO:0004723)
 PMID:22916037
GWAS690524_H GCST90277397 Triacylglycerol (52:3) levels 7,173 Finnish ancestry individuals A 0.272537 4E-9 8.398 rs673548 0.109622 triacylglycerol 52:3 measurement (EFO:0010415)
 PMID:37907536
GWAS690993_H GCST90269660 Free cholesterol in large HDL (UKB data field 23563) 88,329 European ancestry individuals A 0.205544 4E-35 34.398 rs673548 0.0642534 free cholesterol in large HDL measurement (EFO:0022157)
 PMID:36764567
GWAS700068_H GCST90270116 Multi-trait sex score 161,906 European ancestry females ? NR 3E-16 15.523 rs673548 N/A sexual dimorphism measurement (EFO:0021796)
 PMID:37277458
GWAS700555_H GCST001436 Metabolic syndrome 2,637 European ancestry cases, 7,927 European ancestry controls G 0.73 1E-10 10 rs673548 0.11 metabolic syndrome (EFO:0000195)
 PMID:22399527
GWAS701182_H GCST90302126 Total cholesterol levels in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2701 8E-25 24.097 rs673548 0.0475 total cholesterol measurement (EFO:0004574)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS707774_H GCST009242 Serum metabolite levels 6,263 Finnish ancestry men ? NR 6E-10 9.222 rs673548 0.0776248 serum metabolite measurement (EFO:0005653)
 PMID:31636271
GWAS708098_H GCST009242 Serum metabolite levels 6,263 Finnish ancestry men ? NR 1E-12 12 rs673548 0.08938208 serum metabolite measurement (EFO:0005653)
 PMID:31636271
GWAS711255_H GCST90301969 Total cholesterol in HDL2 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2701 2E-44 43.699 rs673548 0.0646 total cholesterol measurement (EFO:0004574)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS711784_H GCST90301971 Total cholesterol levels in HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2702 7E-41 40.155 rs673548 0.0619 total cholesterol measurement (EFO:0004574)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS716642_H GCST90302173 Triglycerides to total lipids ratio in chylomicrons and extremely large VLDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 110,896 European ancestry individuals A 0.2718 1E-27 27 rs673548 0.0529 chylomicron measurement (EFO:0008596)
triglycerides:total lipids ratio (EFO:0020947)
very low density lipoprotein cholesterol measurement (EFO:0008317)
 PMID:38448586
GWAS718316_H GCST007143 Total cholesterol levels 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals G 0.785 1E-17 17 rs673548 0.048 total cholesterol measurement (EFO:0004574)
 PMID:29507422
GWAS718317_H GCST007143 Total cholesterol levels 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals G NR 1E-11 11 rs673548 0.034 total cholesterol measurement (EFO:0004574)
 PMID:29507422
GWAS729522_H GCST009602 Metabolic syndrome 291,107 European ancestry individuals A 0.204049 2E-32 31.699 rs673548 0.0977899 metabolic syndrome (EFO:0000195)
 PMID:31589552
GWAS732173_H GCST90302033 Cholesterol esters in medium HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2689 1E-22 22 rs673548 0.0452 esterified cholesterol measurement (EFO:0008589)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS733140_H GCST90302036 Free cholesterol to total lipids ratio in medium HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2694 2E-15 14.699 rs673548 0.0365 free cholesterol:total lipids ratio (EFO:0020945)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS735127_H GCST90269736 Phospholipids to total lipids in medium HDL percentage (UKB data field 23639) 88,329 European ancestry individuals A 0.205544 2E-28 27.699 rs673548 0.0618733 phospholipids:total lipids ratio (EFO:0020946)
 PMID:36764567
GWAS739249_H GCST90302035 Free cholesterol in medium HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2687 2E-16 15.699 rs673548 0.0377 free cholesterol in medium HDL measurement (EFO:0022267)
 PMID:38448586
GWAS739981_H GCST90302031 Total cholesterol levels in medium HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2688 1E-21 21 rs673548 0.044 total cholesterol measurement (EFO:0004574)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS740808_H GCST008985 Triglycerides 3,681 individuals A 0.221 0.000002 5.699 rs673548 0.053 triglyceride measurement (EFO:0004530)
 PMID:26160806
GWAS742833_H GCST90269735 Triglycerides to total lipids in large HDL percentage (UKB data field 23638) 88,329 European ancestry individuals A 0.205544 2E-54 53.699 rs673548 0.086046 triglycerides to total lipids in large HDL percentage (EFO:0022330)
 PMID:36764567
GWAS744908_H GCST90269703 Cholesteryl esters to total lipids in very small VLDL percentage (UKB data field 23606) 88,329 European ancestry individuals A 0.205544 3E-54 53.523 rs673548 0.0857596 cholesteryl esters to total lipids in very small VLDL percentage (EFO:0022259)
 PMID:36764567
GWAS745060_H GCST90269659 Cholesteryl esters in large HDL (UKB data field 23562) 88,329 European ancestry individuals A 0.205544 7E-34 33.155 rs673548 0.0636423 cholesteryl ester measurement (EFO:0010351)
 PMID:36764567
GWAS745594_H GCST90269658 Cholesterol in large HDL (UKB data field 23561) 88,329 European ancestry individuals A 0.205544 2E-34 33.699 rs673548 0.0639375 cholesterol in large HDL measurement (EFO:0021900)
 PMID:36764567
GWAS749420_H GCST90269737 Cholesterol to total lipids in medium HDL percentage (UKB data field 23640) 88,329 European ancestry individuals A 0.205544 4E-55 54.398 rs673548 0.0875901 cholesterol to total lipids in medium HDL percentage (EFO:0022237)
 PMID:36764567
GWAS752700_H GCST90269739 Free cholesterol to total lipids in medium HDL percentage (UKB data field 23642) 88,329 European ancestry individuals A 0.205544 4E-39 38.398 rs673548 0.068583 free cholesterol to total lipids in medium HDL percentage (EFO:0022282)
 PMID:36764567
GWAS760246_H GCST90302038 Concentration of medium HDL particles 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.269 3E-12 11.523 rs673548 0.0321 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS764368_H GCST90302037 Total lipids in medium HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.269 5E-14 13.302 rs673548 0.0346 total lipids in medium HDL measurement (EFO:0022310)
 PMID:38448586
GWAS764564_H GCST90302039 Phospholipids in medium HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2692 7E-14 13.155 rs673548 0.0344 phospholipids in medium HDL measurement (EFO:0022295)
 PMID:38448586
GWAS766882_H GCST90269655 Concentration of large HDL particles (UKB data field 23558) 88,329 European ancestry individuals A 0.205544 4E-27 26.398 rs673548 0.0561235 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:36764567
GWAS770651_H GCST90269656 Total lipids in large HDL (UKB data field 23559) 88,329 European ancestry individuals A 0.205544 3E-36 35.523 rs673548 0.0654063 total lipids in large HDL (EFO:0022189)
 PMID:36764567
GWAS779689_H GCST90302130 Free cholesterol in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2704 2E-23 22.699 rs673548 0.0463 free cholesterol in very large HDL measurement (EFO:0022273)
 PMID:38448586
GWAS779801_H GCST90302128 Cholesterol esters in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2699 2E-24 23.699 rs673548 0.0471 esterified cholesterol measurement (EFO:0008589)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS781438_H GCST90302133 Concentration of very large HDL particles 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2705 5E-27 26.302 rs673548 0.05 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
GWAS785742_H GCST90302132 Total lipids in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2705 2E-27 26.699 rs673548 0.0504 total lipids in very large HDL measurement (EFO:0022312)
 PMID:38448586
GWAS787493_H GCST90302134 Phospholipids in very large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.2706 1E-30 30 rs673548 0.0533 phospholipids in very large HDL measurement (EFO:0022298)
 PMID:38448586
GWAS815478_H GCST90092851 Concentration of large HDL particles 115,082 European ancestry individuals G 0.793925 2E-29 28.699 rs673548 0.0502503 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS817006_H GCST90092846 Cholesteryl ester levels in large HDL 115,082 European ancestry individuals G 0.793925 1E-37 37 rs673548 0.0575828 cholesteryl ester measurement (EFO:0010351)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
None Available GCST90060212 Ceramide_42:2_[M-H]1- levels 13,814 British ancestry individuals A NR 3E-12 11.523 rs673548 0.0845366 phosphatidylethanolamine measurement (EFO:0010228)
 PMID:34503513
GWAS840219_H GCST90096812 PCSK9 levels 12,721 European ancestry individuals A 0.215583764798365 2E-12 11.699 rs673548 0.0364258 proprotein convertase subtilisin/kexin type 9 measurement (EFO:0009312)
 PMID:34590679
None Available GCST90096813 PCSK9 levels 10,186 European ancestry statin-free individuals A 0.215583764798365 1E-10 10 rs673548 0.0381621 proprotein convertase subtilisin/kexin type 9 measurement (EFO:0009312)
 PMID:34590679
GWAS889885_H GCST90092826 Concentration of HDL particles 115,082 European ancestry individuals G 0.793925 5E-26 25.302 rs673548 0.0504139 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS891071_H GCST90019496 Apolipoprotein B levels 340,860 European ancestry individuals, 5,962 African ancestry individuals, 7,275 South Asian ancestry individuals A NR 6E-219 218.222 rs673548 0.0924 apolipoprotein B measurement (EFO:0004615)
 PMID:33462484
GWAS898295_H GCST90019495 Apolipoprotein A1 levels 311,601 European ancestry individuals, 5,550 African ancestry individuals, 6,682 South Asian ancestry individuals A NR 3E-117 116.523 rs673548 0.0705 apolipoprotein A 1 measurement (EFO:0004614)
 PMID:33462484
GWAS915531_H GCST90092844 Cholesterol levels in large HDL 115,082 European ancestry individuals G 0.793925 5E-38 37.302 rs673548 0.0577476 total cholesterol measurement (EFO:0004574)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS928395_H GCST90092893 Cholesterol to total lipids ratio in medium HDL 115,082 European ancestry individuals G 0.793925 4E-67 66.398 rs673548 0.0836796 cholesterol:total lipids ratio (EFO:0020943)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS931222_H GCST90092901 Phospholipids to total lipids ratio in medium HDL 115,082 European ancestry individuals G 0.793925 2E-33 32.699 rs673548 0.0582136 phospholipids:total lipids ratio (EFO:0020946)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS931719_H GCST90092897 Free cholesterol to total lipids ratio in medium HDL 115,082 European ancestry individuals G 0.793925 4E-44 43.398 rs673548 0.0627809 free cholesterol:total lipids ratio (EFO:0020945)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
GWAS932840_H GCST90019501 Total cholesterol levels 342,508 European ancestry individuals, 6,014 African ancestry individuals, 7,336 South Asian ancestry individuals A NR 1E-55 55 rs673548 0.0459 total cholesterol measurement (EFO:0004574)
 PMID:33462484
GWAS939078_H GCST90092941 Ratio of polyunsaturated fatty acids to total fatty acids 115,006 European ancestry individuals G 0.793911 2E-18 17.699 rs673548 0.0428037 fatty acid measurement (EFO:0005110)
 PMID:35213538
GWAS942059_H GCST90019510 High density lipoprotein cholesterol levels 313,372 European ancestry individuals, 5,573 African ancestry individuals, 6,689 South Asian ancestry individuals A NR 2E-119 118.699 rs673548 0.071 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:33462484
GWAS945699_H GCST90092940 Ratio of polyunsaturated fatty acids to monounsaturated fatty acids 115,006 European ancestry individuals G 0.793911 1E-38 38 rs673548 0.0632408 fatty acid measurement (EFO:0005110)
 PMID:35213538
GWAS972710_H GCST90019523 Triglyceride levels 342,233 European ancestry individuals, 6,014 African ancestry individuals, 7,330 South Asian ancestry individuals A NR 1E-173 173 rs673548 0.082 triglyceride measurement (EFO:0004530)
 PMID:33462484
GWAS981629_H GCST90093037 Phospholipids to total lipids ratio in very small VLDL 115,082 European ancestry individuals G 0.793925 2E-64 63.699 rs673548 0.0840744 very low density lipoprotein cholesterol measurement (EFO:0008317)
phospholipids:total lipids ratio (EFO:0020946)
 PMID:35213538
GWAS982376_H GCST90019512 Low density lipoprotein cholesterol levels 341,875 European ancestry individuals, 6,003 African ancestry individuals, 7,319 South Asian ancestry individuals A NR 5E-112 111.302 rs673548 0.0657 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:33462484
Database Acc Id Source(s)
GWAS Catalog GCST007140 GWAS Catalog

RGD Curation Notes
Note Type Note Reference